Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000100004 |
Resumo: | INTRODUCTION: The development of research for diagnosis, prevention and treatment of atherosclerotic cardiovascular disease is of utmost importance due to the fact that it is the main cause of morbidity and mortality in Brazil. OBJECTIVE: To demonstrate the phases of the selection process for candidates with the aim to develop a clinical-laboratorial database of hyper alpha lipoproteinemic patients (hyper A) - high density lipoprotein cholesterol (HDL-C) ≥ 68 mg/dl) and hypo alpha lipoproteinemic patients (hypo A) - HDL-C < 39 mg/dl. MATERIAL AND METHODS: The volunteers were contacted after selection of lipid profiles from individuals treated at the Sistema Único de Saúde (SUS), Campinas-SP and neighboring area. Afterwards, the selected patients went through blood collection, clinical examinations and answered questionnaires on dietary frequency and physical activity. After this preliminary evaluation, some individuals were convened to another blood collection and, subsequently, were submitted to an ultrasonographic exam of the carotid arteries. RESULTS: Only 0.6% and 0.3% from 598,288 lipid profiles were selected for hyper A and hypo A groups, respectively, including gender disparity. Lack of effective questionnaires (75%), missing calls (60%) and non-inclusion were the major hindrances in the construction of this database. DISCUSSION: The difficulties to obtain eligible candidates were also due to the low prevalence of both groups hypo A and hyper A and the high prevalence of pathologies that contribute to non-genetic variations of HDL-C. CONCLUSION: In spite of the obstacles in the development of this database, this study brought about several scientific publications. Furthermore, the development of molecular analyzes and functionality will shortly generate other findings, contributing to the diagnosis and follow-up of HDL dyslipidemias. |
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Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring regionhealth institutesHDL-Cdata collectionINTRODUCTION: The development of research for diagnosis, prevention and treatment of atherosclerotic cardiovascular disease is of utmost importance due to the fact that it is the main cause of morbidity and mortality in Brazil. OBJECTIVE: To demonstrate the phases of the selection process for candidates with the aim to develop a clinical-laboratorial database of hyper alpha lipoproteinemic patients (hyper A) - high density lipoprotein cholesterol (HDL-C) ≥ 68 mg/dl) and hypo alpha lipoproteinemic patients (hypo A) - HDL-C < 39 mg/dl. MATERIAL AND METHODS: The volunteers were contacted after selection of lipid profiles from individuals treated at the Sistema Único de Saúde (SUS), Campinas-SP and neighboring area. Afterwards, the selected patients went through blood collection, clinical examinations and answered questionnaires on dietary frequency and physical activity. After this preliminary evaluation, some individuals were convened to another blood collection and, subsequently, were submitted to an ultrasonographic exam of the carotid arteries. RESULTS: Only 0.6% and 0.3% from 598,288 lipid profiles were selected for hyper A and hypo A groups, respectively, including gender disparity. Lack of effective questionnaires (75%), missing calls (60%) and non-inclusion were the major hindrances in the construction of this database. DISCUSSION: The difficulties to obtain eligible candidates were also due to the low prevalence of both groups hypo A and hyper A and the high prevalence of pathologies that contribute to non-genetic variations of HDL-C. CONCLUSION: In spite of the obstacles in the development of this database, this study brought about several scientific publications. Furthermore, the development of molecular analyzes and functionality will shortly generate other findings, contributing to the diagnosis and follow-up of HDL dyslipidemias.Sociedade Brasileira de Patologia Clínica2013-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000100004Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.1 2013reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442013000100004info:eu-repo/semantics/openAccessParra,Eliane SolerZago,Vanessa Helena de SouzaPanzoldo,Natália BaratellaAlexandre,FernandaVendrame,FelipeVirginio,Vitor Wilson de MouraVieira,Isabela CalancaRodrigues,Marcelo Scarpari DutraCassol,Angela de SouzaD'Alexandri,FabioCastanho,Vera SylviaNakamura,RuiBaracat,JamalDanelon,Mirian Regina GardinPozeti,Ronise Carla SassFacin,Ana Cândida CoutinhoHonorio,Hilda Maria da SilvaMesquita,Simone de Cássia DiasSilva,Marcio Jorge daLot,Marielza Crosgnac FeresNunes,Valéria SuttiLeança,Camila CanteiroNakandakare,Edna ReginaQuintão,Eder Carlos RochaFaria,Eliana Cotta deeng2013-05-20T00:00:00Zoai:scielo:S1676-24442013000100004Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2013-05-20T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false |
dc.title.none.fl_str_mv |
Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region |
title |
Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region |
spellingShingle |
Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region Parra,Eliane Soler health institutes HDL-C data collection |
title_short |
Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region |
title_full |
Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region |
title_fullStr |
Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region |
title_full_unstemmed |
Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region |
title_sort |
Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region |
author |
Parra,Eliane Soler |
author_facet |
Parra,Eliane Soler Zago,Vanessa Helena de Souza Panzoldo,Natália Baratella Alexandre,Fernanda Vendrame,Felipe Virginio,Vitor Wilson de Moura Vieira,Isabela Calanca Rodrigues,Marcelo Scarpari Dutra Cassol,Angela de Souza D'Alexandri,Fabio Castanho,Vera Sylvia Nakamura,Rui Baracat,Jamal Danelon,Mirian Regina Gardin Pozeti,Ronise Carla Sass Facin,Ana Cândida Coutinho Honorio,Hilda Maria da Silva Mesquita,Simone de Cássia Dias Silva,Marcio Jorge da Lot,Marielza Crosgnac Feres Nunes,Valéria Sutti Leança,Camila Canteiro Nakandakare,Edna Regina Quintão,Eder Carlos Rocha Faria,Eliana Cotta de |
author_role |
author |
author2 |
Zago,Vanessa Helena de Souza Panzoldo,Natália Baratella Alexandre,Fernanda Vendrame,Felipe Virginio,Vitor Wilson de Moura Vieira,Isabela Calanca Rodrigues,Marcelo Scarpari Dutra Cassol,Angela de Souza D'Alexandri,Fabio Castanho,Vera Sylvia Nakamura,Rui Baracat,Jamal Danelon,Mirian Regina Gardin Pozeti,Ronise Carla Sass Facin,Ana Cândida Coutinho Honorio,Hilda Maria da Silva Mesquita,Simone de Cássia Dias Silva,Marcio Jorge da Lot,Marielza Crosgnac Feres Nunes,Valéria Sutti Leança,Camila Canteiro Nakandakare,Edna Regina Quintão,Eder Carlos Rocha Faria,Eliana Cotta de |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Parra,Eliane Soler Zago,Vanessa Helena de Souza Panzoldo,Natália Baratella Alexandre,Fernanda Vendrame,Felipe Virginio,Vitor Wilson de Moura Vieira,Isabela Calanca Rodrigues,Marcelo Scarpari Dutra Cassol,Angela de Souza D'Alexandri,Fabio Castanho,Vera Sylvia Nakamura,Rui Baracat,Jamal Danelon,Mirian Regina Gardin Pozeti,Ronise Carla Sass Facin,Ana Cândida Coutinho Honorio,Hilda Maria da Silva Mesquita,Simone de Cássia Dias Silva,Marcio Jorge da Lot,Marielza Crosgnac Feres Nunes,Valéria Sutti Leança,Camila Canteiro Nakandakare,Edna Regina Quintão,Eder Carlos Rocha Faria,Eliana Cotta de |
dc.subject.por.fl_str_mv |
health institutes HDL-C data collection |
topic |
health institutes HDL-C data collection |
description |
INTRODUCTION: The development of research for diagnosis, prevention and treatment of atherosclerotic cardiovascular disease is of utmost importance due to the fact that it is the main cause of morbidity and mortality in Brazil. OBJECTIVE: To demonstrate the phases of the selection process for candidates with the aim to develop a clinical-laboratorial database of hyper alpha lipoproteinemic patients (hyper A) - high density lipoprotein cholesterol (HDL-C) ≥ 68 mg/dl) and hypo alpha lipoproteinemic patients (hypo A) - HDL-C < 39 mg/dl. MATERIAL AND METHODS: The volunteers were contacted after selection of lipid profiles from individuals treated at the Sistema Único de Saúde (SUS), Campinas-SP and neighboring area. Afterwards, the selected patients went through blood collection, clinical examinations and answered questionnaires on dietary frequency and physical activity. After this preliminary evaluation, some individuals were convened to another blood collection and, subsequently, were submitted to an ultrasonographic exam of the carotid arteries. RESULTS: Only 0.6% and 0.3% from 598,288 lipid profiles were selected for hyper A and hypo A groups, respectively, including gender disparity. Lack of effective questionnaires (75%), missing calls (60%) and non-inclusion were the major hindrances in the construction of this database. DISCUSSION: The difficulties to obtain eligible candidates were also due to the low prevalence of both groups hypo A and hyper A and the high prevalence of pathologies that contribute to non-genetic variations of HDL-C. CONCLUSION: In spite of the obstacles in the development of this database, this study brought about several scientific publications. Furthermore, the development of molecular analyzes and functionality will shortly generate other findings, contributing to the diagnosis and follow-up of HDL dyslipidemias. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000100004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000100004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1676-24442013000100004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.1 2013 reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) instname:Sociedade Brasileira de Patologia (SBP) instacron:SBP |
instname_str |
Sociedade Brasileira de Patologia (SBP) |
instacron_str |
SBP |
institution |
SBP |
reponame_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
collection |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP) |
repository.mail.fl_str_mv |
||jbpml@sbpc.org.br |
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1752122295807115264 |