Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantation

Detalhes bibliográficos
Autor(a) principal: Benites Filho,Paulo R.
Data de Publicação: 2007
Outros Autores: Almeida,Luis G. M. Pinto de, Zanis Neto,José, Pasquini,Ricardo, Bleggi-Torres,Luiz F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442007000600006
Resumo: BACKGROUND: We compare neuropathological abnormalities in children and adults after bone marrow transplantation (BMT) by means of autopsy in the Department of Medical Pathology, Universidade Federal do Paraná (UFPR), Brazil. METHODS: Autopsy reports of 180 patients were reviewed. They were divided in two groups: patients under 15 years old and those 15 or older. Age, gender, clinical diagnosis at time of BMT, survival time, neuropathological abnormalities and cause of death were analyzed. RESULTS: In children (26.6% of total) and in the adult group (73.4% of total), the main clinical diagnoses prior to BMT were, respectively, severe aplastic anemia (31.2%) and chronic myeloid leukemia (36.3%). The mean survival time for children was 102.6 days and for adults, 185.9 days after BMT. Brain lesions were considered cause of death in 20.8% of pediatric cases and 11.3% of the adult group. Neuropathological abnormalities were morphologically similar in children and adults, with the following respectively prevalence: cerebrovascular diseases in 58.3 and 56% (p = 0.8655), neurotoxoplasmosis in 6.2% and 3% (p = 0.3856) and infections in 27 and 25.7% (p = 0.8489). CONCLUSIONS: The pediatric patients had shorter survival than adults, with increasing prevalence of neurotoxoplasmosis, and brain lesions were considered cause of death in twice as many as compared to adult patients.
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spelling Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantationBone marrowtransplantationBrain diseasesAutopsyBACKGROUND: We compare neuropathological abnormalities in children and adults after bone marrow transplantation (BMT) by means of autopsy in the Department of Medical Pathology, Universidade Federal do Paraná (UFPR), Brazil. METHODS: Autopsy reports of 180 patients were reviewed. They were divided in two groups: patients under 15 years old and those 15 or older. Age, gender, clinical diagnosis at time of BMT, survival time, neuropathological abnormalities and cause of death were analyzed. RESULTS: In children (26.6% of total) and in the adult group (73.4% of total), the main clinical diagnoses prior to BMT were, respectively, severe aplastic anemia (31.2%) and chronic myeloid leukemia (36.3%). The mean survival time for children was 102.6 days and for adults, 185.9 days after BMT. Brain lesions were considered cause of death in 20.8% of pediatric cases and 11.3% of the adult group. Neuropathological abnormalities were morphologically similar in children and adults, with the following respectively prevalence: cerebrovascular diseases in 58.3 and 56% (p = 0.8655), neurotoxoplasmosis in 6.2% and 3% (p = 0.3856) and infections in 27 and 25.7% (p = 0.8489). CONCLUSIONS: The pediatric patients had shorter survival than adults, with increasing prevalence of neurotoxoplasmosis, and brain lesions were considered cause of death in twice as many as compared to adult patients.Sociedade Brasileira de Patologia Clínica2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442007000600006Jornal Brasileiro de Patologia e Medicina Laboratorial v.43 n.6 2007reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442007000600006info:eu-repo/semantics/openAccessBenites Filho,Paulo R.Almeida,Luis G. M. Pinto deZanis Neto,JoséPasquini,RicardoBleggi-Torres,Luiz F.eng2008-03-06T00:00:00Zoai:scielo:S1676-24442007000600006Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2008-03-06T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantation
title Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantation
spellingShingle Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantation
Benites Filho,Paulo R.
Bone marrow
transplantation
Brain diseases
Autopsy
title_short Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantation
title_full Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantation
title_fullStr Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantation
title_full_unstemmed Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantation
title_sort Comparative study of abnormalities of central nervous system in children and adults autopsied after bone marrow transplantation
author Benites Filho,Paulo R.
author_facet Benites Filho,Paulo R.
Almeida,Luis G. M. Pinto de
Zanis Neto,José
Pasquini,Ricardo
Bleggi-Torres,Luiz F.
author_role author
author2 Almeida,Luis G. M. Pinto de
Zanis Neto,José
Pasquini,Ricardo
Bleggi-Torres,Luiz F.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Benites Filho,Paulo R.
Almeida,Luis G. M. Pinto de
Zanis Neto,José
Pasquini,Ricardo
Bleggi-Torres,Luiz F.
dc.subject.por.fl_str_mv Bone marrow
transplantation
Brain diseases
Autopsy
topic Bone marrow
transplantation
Brain diseases
Autopsy
description BACKGROUND: We compare neuropathological abnormalities in children and adults after bone marrow transplantation (BMT) by means of autopsy in the Department of Medical Pathology, Universidade Federal do Paraná (UFPR), Brazil. METHODS: Autopsy reports of 180 patients were reviewed. They were divided in two groups: patients under 15 years old and those 15 or older. Age, gender, clinical diagnosis at time of BMT, survival time, neuropathological abnormalities and cause of death were analyzed. RESULTS: In children (26.6% of total) and in the adult group (73.4% of total), the main clinical diagnoses prior to BMT were, respectively, severe aplastic anemia (31.2%) and chronic myeloid leukemia (36.3%). The mean survival time for children was 102.6 days and for adults, 185.9 days after BMT. Brain lesions were considered cause of death in 20.8% of pediatric cases and 11.3% of the adult group. Neuropathological abnormalities were morphologically similar in children and adults, with the following respectively prevalence: cerebrovascular diseases in 58.3 and 56% (p = 0.8655), neurotoxoplasmosis in 6.2% and 3% (p = 0.3856) and infections in 27 and 25.7% (p = 0.8489). CONCLUSIONS: The pediatric patients had shorter survival than adults, with increasing prevalence of neurotoxoplasmosis, and brain lesions were considered cause of death in twice as many as compared to adult patients.
publishDate 2007
dc.date.none.fl_str_mv 2007-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442007000600006
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1676-24442007000600006
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dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.43 n.6 2007
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
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