RAGE receptor and its soluble isoforms in diabetes mellitus complications

Detalhes bibliográficos
Autor(a) principal: Oliveira,Mauren Isfer Anghebem
Data de Publicação: 2013
Outros Autores: Souza,Emanuel Maltempi de, Pedrosa,Fábio de Oliveira, Réa,Rosângela Roginski, Alves,Alexessander da Silva Couto, Picheth,Geraldo, Rego,Fabiane Gomes de Moraes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200004
Resumo: Chronic hyperglycemia, which is present in all types of diabetes, increases the formation of advanced glycation end-products (AGEs). The interaction of AGEs with receptor of advanced glycation end-products (RAGE) initiates a cascade of pro-inflammatory and pro-coagulant processes that result in oxidative stress, stimulating the formation and accumulation of more AGE molecules. This cyclic process, denominated metabolic memory, may explain the persistency of diabetic vascular complications in patients with satisfactory glycemic control. The RAGE found in several cell membranes is also present in soluble isoforms (esRAGE and cRAGE), which are generated by alternative deoxyribonucleic acid splicing or by proteolytic cleavage. This review focuses on new research into these mediators as potential biomarkers for vascular complications in diabetes.
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spelling RAGE receptor and its soluble isoforms in diabetes mellitus complicationsRAGE receptorRAGE soluble isoformsRAGE isoformsdiabetes complicationsChronic hyperglycemia, which is present in all types of diabetes, increases the formation of advanced glycation end-products (AGEs). The interaction of AGEs with receptor of advanced glycation end-products (RAGE) initiates a cascade of pro-inflammatory and pro-coagulant processes that result in oxidative stress, stimulating the formation and accumulation of more AGE molecules. This cyclic process, denominated metabolic memory, may explain the persistency of diabetic vascular complications in patients with satisfactory glycemic control. The RAGE found in several cell membranes is also present in soluble isoforms (esRAGE and cRAGE), which are generated by alternative deoxyribonucleic acid splicing or by proteolytic cleavage. This review focuses on new research into these mediators as potential biomarkers for vascular complications in diabetes.Sociedade Brasileira de Patologia Clínica2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200004Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.2 2013reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442013000200004info:eu-repo/semantics/openAccessOliveira,Mauren Isfer AnghebemSouza,Emanuel Maltempi dePedrosa,Fábio de OliveiraRéa,Rosângela RoginskiAlves,Alexessander da Silva CoutoPicheth,GeraldoRego,Fabiane Gomes de Moraeseng2013-06-24T00:00:00Zoai:scielo:S1676-24442013000200004Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2013-06-24T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv RAGE receptor and its soluble isoforms in diabetes mellitus complications
title RAGE receptor and its soluble isoforms in diabetes mellitus complications
spellingShingle RAGE receptor and its soluble isoforms in diabetes mellitus complications
Oliveira,Mauren Isfer Anghebem
RAGE receptor
RAGE soluble isoforms
RAGE isoforms
diabetes complications
title_short RAGE receptor and its soluble isoforms in diabetes mellitus complications
title_full RAGE receptor and its soluble isoforms in diabetes mellitus complications
title_fullStr RAGE receptor and its soluble isoforms in diabetes mellitus complications
title_full_unstemmed RAGE receptor and its soluble isoforms in diabetes mellitus complications
title_sort RAGE receptor and its soluble isoforms in diabetes mellitus complications
author Oliveira,Mauren Isfer Anghebem
author_facet Oliveira,Mauren Isfer Anghebem
Souza,Emanuel Maltempi de
Pedrosa,Fábio de Oliveira
Réa,Rosângela Roginski
Alves,Alexessander da Silva Couto
Picheth,Geraldo
Rego,Fabiane Gomes de Moraes
author_role author
author2 Souza,Emanuel Maltempi de
Pedrosa,Fábio de Oliveira
Réa,Rosângela Roginski
Alves,Alexessander da Silva Couto
Picheth,Geraldo
Rego,Fabiane Gomes de Moraes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Mauren Isfer Anghebem
Souza,Emanuel Maltempi de
Pedrosa,Fábio de Oliveira
Réa,Rosângela Roginski
Alves,Alexessander da Silva Couto
Picheth,Geraldo
Rego,Fabiane Gomes de Moraes
dc.subject.por.fl_str_mv RAGE receptor
RAGE soluble isoforms
RAGE isoforms
diabetes complications
topic RAGE receptor
RAGE soluble isoforms
RAGE isoforms
diabetes complications
description Chronic hyperglycemia, which is present in all types of diabetes, increases the formation of advanced glycation end-products (AGEs). The interaction of AGEs with receptor of advanced glycation end-products (RAGE) initiates a cascade of pro-inflammatory and pro-coagulant processes that result in oxidative stress, stimulating the formation and accumulation of more AGE molecules. This cyclic process, denominated metabolic memory, may explain the persistency of diabetic vascular complications in patients with satisfactory glycemic control. The RAGE found in several cell membranes is also present in soluble isoforms (esRAGE and cRAGE), which are generated by alternative deoxyribonucleic acid splicing or by proteolytic cleavage. This review focuses on new research into these mediators as potential biomarkers for vascular complications in diabetes.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1676-24442013000200004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.2 2013
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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