Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinoma

Detalhes bibliográficos
Autor(a) principal: Cambruzzi,Eduardo
Data de Publicação: 2015
Outros Autores: Gassen,Luana R., Reginatto,Andrei, Noshang,Andressa, Brandão,Fernanda P., Roman,Larissa R., Miranda,Luciana H., Pêgas,Karla Lais
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000500323
Resumo: ABSTRACTIntroduction:Breast invasive carcinoma of no special type (NST) is characterized by great morphological heterogeneity, and accounts for about 70%-80% of malignant breast tumors. The main prognostic factors are tumor size, degree of differentiation, and status of axillary lymph nodes. NST represents 15%-18% of central nervous system metastases (CNSm), and generally the response to systemic treatment/chemotherapy is unsatisfactory.Objective:To estimate the association between clinical and pathological findings of NST with CNSm.Method:Clinical data of 171 specimens of lumpectomy/mastectomy with axillary dissection in NST were evaluated, as well as the following pathological variables: tumor size, histological grade, nodal status, expression of estrogen (ER) and progesterone receptors (PR) and human epidermal growth factor receptor 2 (HER-2/neu) oncogene (c-erb B2), and presence of CNSm. The cases of CNSm in NST underwent resection, and the primary site was identified by immunohistochemistry.Results:The prevalence of CNSm was 9.4% (n = 16), and was related to age (p = 0.01), and the expression of PR (p = 0.004). Although cases of NST with CNSm showed correlation with greater tumor size, higher histological grade and nodal metastases, there was no statistical association (p = 0.221, p = 0.224 and p = 0.99, respectively). Expression of ER and c-erb-B2 was not significant between the two groups (p = 0.072 and p = 0.31, respectively).Conclusion:This study showed that younger patients and the expression of RP correlate with the presence of CNSm. The evaluation of specific pathological findings in NST can help establish risk factors and/or clinical parameters associated with the development of CNSm.
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spelling Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinomacentral nervous systemcarcinomabreastneoplasm metastasispathologyABSTRACTIntroduction:Breast invasive carcinoma of no special type (NST) is characterized by great morphological heterogeneity, and accounts for about 70%-80% of malignant breast tumors. The main prognostic factors are tumor size, degree of differentiation, and status of axillary lymph nodes. NST represents 15%-18% of central nervous system metastases (CNSm), and generally the response to systemic treatment/chemotherapy is unsatisfactory.Objective:To estimate the association between clinical and pathological findings of NST with CNSm.Method:Clinical data of 171 specimens of lumpectomy/mastectomy with axillary dissection in NST were evaluated, as well as the following pathological variables: tumor size, histological grade, nodal status, expression of estrogen (ER) and progesterone receptors (PR) and human epidermal growth factor receptor 2 (HER-2/neu) oncogene (c-erb B2), and presence of CNSm. The cases of CNSm in NST underwent resection, and the primary site was identified by immunohistochemistry.Results:The prevalence of CNSm was 9.4% (n = 16), and was related to age (p = 0.01), and the expression of PR (p = 0.004). Although cases of NST with CNSm showed correlation with greater tumor size, higher histological grade and nodal metastases, there was no statistical association (p = 0.221, p = 0.224 and p = 0.99, respectively). Expression of ER and c-erb-B2 was not significant between the two groups (p = 0.072 and p = 0.31, respectively).Conclusion:This study showed that younger patients and the expression of RP correlate with the presence of CNSm. The evaluation of specific pathological findings in NST can help establish risk factors and/or clinical parameters associated with the development of CNSm.Sociedade Brasileira de Patologia Clínica2015-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000500323Jornal Brasileiro de Patologia e Medicina Laboratorial v.51 n.5 2015reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20150052info:eu-repo/semantics/openAccessCambruzzi,EduardoGassen,Luana R.Reginatto,AndreiNoshang,AndressaBrandão,Fernanda P.Roman,Larissa R.Miranda,Luciana H.Pêgas,Karla Laiseng2015-11-10T00:00:00Zoai:scielo:S1676-24442015000500323Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2015-11-10T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinoma
title Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinoma
spellingShingle Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinoma
Cambruzzi,Eduardo
central nervous system
carcinoma
breast
neoplasm metastasis
pathology
title_short Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinoma
title_full Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinoma
title_fullStr Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinoma
title_full_unstemmed Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinoma
title_sort Relationship between age and progesterone receptor expression with presence of central nervous system metastases in breast invasive ductal carcinoma
author Cambruzzi,Eduardo
author_facet Cambruzzi,Eduardo
Gassen,Luana R.
Reginatto,Andrei
Noshang,Andressa
Brandão,Fernanda P.
Roman,Larissa R.
Miranda,Luciana H.
Pêgas,Karla Lais
author_role author
author2 Gassen,Luana R.
Reginatto,Andrei
Noshang,Andressa
Brandão,Fernanda P.
Roman,Larissa R.
Miranda,Luciana H.
Pêgas,Karla Lais
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cambruzzi,Eduardo
Gassen,Luana R.
Reginatto,Andrei
Noshang,Andressa
Brandão,Fernanda P.
Roman,Larissa R.
Miranda,Luciana H.
Pêgas,Karla Lais
dc.subject.por.fl_str_mv central nervous system
carcinoma
breast
neoplasm metastasis
pathology
topic central nervous system
carcinoma
breast
neoplasm metastasis
pathology
description ABSTRACTIntroduction:Breast invasive carcinoma of no special type (NST) is characterized by great morphological heterogeneity, and accounts for about 70%-80% of malignant breast tumors. The main prognostic factors are tumor size, degree of differentiation, and status of axillary lymph nodes. NST represents 15%-18% of central nervous system metastases (CNSm), and generally the response to systemic treatment/chemotherapy is unsatisfactory.Objective:To estimate the association between clinical and pathological findings of NST with CNSm.Method:Clinical data of 171 specimens of lumpectomy/mastectomy with axillary dissection in NST were evaluated, as well as the following pathological variables: tumor size, histological grade, nodal status, expression of estrogen (ER) and progesterone receptors (PR) and human epidermal growth factor receptor 2 (HER-2/neu) oncogene (c-erb B2), and presence of CNSm. The cases of CNSm in NST underwent resection, and the primary site was identified by immunohistochemistry.Results:The prevalence of CNSm was 9.4% (n = 16), and was related to age (p = 0.01), and the expression of PR (p = 0.004). Although cases of NST with CNSm showed correlation with greater tumor size, higher histological grade and nodal metastases, there was no statistical association (p = 0.221, p = 0.224 and p = 0.99, respectively). Expression of ER and c-erb-B2 was not significant between the two groups (p = 0.072 and p = 0.31, respectively).Conclusion:This study showed that younger patients and the expression of RP correlate with the presence of CNSm. The evaluation of specific pathological findings in NST can help establish risk factors and/or clinical parameters associated with the development of CNSm.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000500323
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000500323
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20150052
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.51 n.5 2015
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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