Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamus

Detalhes bibliográficos
Autor(a) principal: Cambruzzi,Eduardo
Data de Publicação: 2013
Outros Autores: Pêgas,Karla Lais, Simão,Mariana Fernandez, Stüker,Guilherme
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200010
Resumo: Multicentric glioblastomas (MGBM) arising in infra/supratentorial regions are uncommon lesions. The authors report a case of MGBM in a 61 year-old female patient, who presented a sudden onset of left hemiplegia. The magnetic resonance imaging (MRI) showed two expansive large lesions affecting cerebellum and thalamus, with strong contrast enhancement. The patient underwent resection of the cerebellar lesion. Microscopy revealed a high grade glial neoplasm exhibiting high mitotic index, areas of necrosis and microvascular proliferation. The neoplastic cells showed positive immunoexpression for glial fibrillary acidic protein (GFAP). The morphological findings were consistent with glioblastoma (GBM). The patient was referred to radiotherapy, with discrete signs of tumor regression after a 60-day clinical follow-up.
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spelling Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamusglioblastomacentral nervous system neoplasmspathologybrain neoplasmscerebellumthalamusMulticentric glioblastomas (MGBM) arising in infra/supratentorial regions are uncommon lesions. The authors report a case of MGBM in a 61 year-old female patient, who presented a sudden onset of left hemiplegia. The magnetic resonance imaging (MRI) showed two expansive large lesions affecting cerebellum and thalamus, with strong contrast enhancement. The patient underwent resection of the cerebellar lesion. Microscopy revealed a high grade glial neoplasm exhibiting high mitotic index, areas of necrosis and microvascular proliferation. The neoplastic cells showed positive immunoexpression for glial fibrillary acidic protein (GFAP). The morphological findings were consistent with glioblastoma (GBM). The patient was referred to radiotherapy, with discrete signs of tumor regression after a 60-day clinical follow-up.Sociedade Brasileira de Patologia Clínica2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200010Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.2 2013reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442013000200010info:eu-repo/semantics/openAccessCambruzzi,EduardoPêgas,Karla LaisSimão,Mariana FernandezStüker,Guilhermeeng2013-06-24T00:00:00Zoai:scielo:S1676-24442013000200010Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2013-06-24T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamus
title Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamus
spellingShingle Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamus
Cambruzzi,Eduardo
glioblastoma
central nervous system neoplasms
pathology
brain neoplasms
cerebellum
thalamus
title_short Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamus
title_full Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamus
title_fullStr Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamus
title_full_unstemmed Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamus
title_sort Multicentric glioblastoma arising in two unusual sites: cerebellum and thalamus
author Cambruzzi,Eduardo
author_facet Cambruzzi,Eduardo
Pêgas,Karla Lais
Simão,Mariana Fernandez
Stüker,Guilherme
author_role author
author2 Pêgas,Karla Lais
Simão,Mariana Fernandez
Stüker,Guilherme
author2_role author
author
author
dc.contributor.author.fl_str_mv Cambruzzi,Eduardo
Pêgas,Karla Lais
Simão,Mariana Fernandez
Stüker,Guilherme
dc.subject.por.fl_str_mv glioblastoma
central nervous system neoplasms
pathology
brain neoplasms
cerebellum
thalamus
topic glioblastoma
central nervous system neoplasms
pathology
brain neoplasms
cerebellum
thalamus
description Multicentric glioblastomas (MGBM) arising in infra/supratentorial regions are uncommon lesions. The authors report a case of MGBM in a 61 year-old female patient, who presented a sudden onset of left hemiplegia. The magnetic resonance imaging (MRI) showed two expansive large lesions affecting cerebellum and thalamus, with strong contrast enhancement. The patient underwent resection of the cerebellar lesion. Microscopy revealed a high grade glial neoplasm exhibiting high mitotic index, areas of necrosis and microvascular proliferation. The neoplastic cells showed positive immunoexpression for glial fibrillary acidic protein (GFAP). The morphological findings were consistent with glioblastoma (GBM). The patient was referred to radiotherapy, with discrete signs of tumor regression after a 60-day clinical follow-up.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1676-24442013000200010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.2 2013
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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