Influence of interleukins on prognosis of patients with oral squamous cells carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000500550 |
Resumo: | ABSTRACT Squamous cell carcinoma is a malignant neoplasm that affects the structures and tissues of the oral cavity. Interleukins (IL) synthesized from a tumor modulate a cascade reaction that may influence the prognosis of the disease. We aim to investigate in the literature whether interleukins are mediators that negatively or positively influence the prognosis of patients with oral squamous cell carcinoma. A systematic review study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) instructions. PubMed (including MedLine), Scopus, Web of Science, SciELO and Latin American and Caribbean Health Sciences (LILACS) databases were used as the primary sources for the study; OpenGrey and OpenThesis were used to search for "gray literature". The search conducted in seven general databases resulted in a set of 858 studies, while the search conducted in two databases for gray literature resulted in 82 studies, totaling 940 studies. From these, 15 studies were selected for this systematic review (eight studies presented low bias risk; four studies presented moderate bias risk; and three studies presented high risk of bias). Although they may act on the anti-tumor immune response pathways, the IL evaluated in the present systematic review (IL-4, IL-6, IL-8, IL-10, IL-12 and IL-13) tend to present a response associated with the intensification of carcinogenesis and poor prognosis in patients with oral squamous cell carcinoma. |
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Influence of interleukins on prognosis of patients with oral squamous cells carcinomaneoplasmsinterleukinshead and neck neoplasmsoral squamous cell carcinomaABSTRACT Squamous cell carcinoma is a malignant neoplasm that affects the structures and tissues of the oral cavity. Interleukins (IL) synthesized from a tumor modulate a cascade reaction that may influence the prognosis of the disease. We aim to investigate in the literature whether interleukins are mediators that negatively or positively influence the prognosis of patients with oral squamous cell carcinoma. A systematic review study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) instructions. PubMed (including MedLine), Scopus, Web of Science, SciELO and Latin American and Caribbean Health Sciences (LILACS) databases were used as the primary sources for the study; OpenGrey and OpenThesis were used to search for "gray literature". The search conducted in seven general databases resulted in a set of 858 studies, while the search conducted in two databases for gray literature resulted in 82 studies, totaling 940 studies. From these, 15 studies were selected for this systematic review (eight studies presented low bias risk; four studies presented moderate bias risk; and three studies presented high risk of bias). Although they may act on the anti-tumor immune response pathways, the IL evaluated in the present systematic review (IL-4, IL-6, IL-8, IL-10, IL-12 and IL-13) tend to present a response associated with the intensification of carcinogenesis and poor prognosis in patients with oral squamous cell carcinoma.Sociedade Brasileira de Patologia Clínica2019-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000500550Jornal Brasileiro de Patologia e Medicina Laboratorial v.55 n.5 2019reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20190051info:eu-repo/semantics/openAccessAlmeida,Vinícius L.Santana,Ingrede Tatiane S.Santos,José Nilson A.Fontes,Gabryelle S.Lima,Igor Felipe P.Matos,Ana Liz P.Matos,Felipe R.Paranhos,Luiz Renatoeng2019-11-06T00:00:00Zoai:scielo:S1676-24442019000500550Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2019-11-06T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false |
dc.title.none.fl_str_mv |
Influence of interleukins on prognosis of patients with oral squamous cells carcinoma |
title |
Influence of interleukins on prognosis of patients with oral squamous cells carcinoma |
spellingShingle |
Influence of interleukins on prognosis of patients with oral squamous cells carcinoma Almeida,Vinícius L. neoplasms interleukins head and neck neoplasms oral squamous cell carcinoma |
title_short |
Influence of interleukins on prognosis of patients with oral squamous cells carcinoma |
title_full |
Influence of interleukins on prognosis of patients with oral squamous cells carcinoma |
title_fullStr |
Influence of interleukins on prognosis of patients with oral squamous cells carcinoma |
title_full_unstemmed |
Influence of interleukins on prognosis of patients with oral squamous cells carcinoma |
title_sort |
Influence of interleukins on prognosis of patients with oral squamous cells carcinoma |
author |
Almeida,Vinícius L. |
author_facet |
Almeida,Vinícius L. Santana,Ingrede Tatiane S. Santos,José Nilson A. Fontes,Gabryelle S. Lima,Igor Felipe P. Matos,Ana Liz P. Matos,Felipe R. Paranhos,Luiz Renato |
author_role |
author |
author2 |
Santana,Ingrede Tatiane S. Santos,José Nilson A. Fontes,Gabryelle S. Lima,Igor Felipe P. Matos,Ana Liz P. Matos,Felipe R. Paranhos,Luiz Renato |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Almeida,Vinícius L. Santana,Ingrede Tatiane S. Santos,José Nilson A. Fontes,Gabryelle S. Lima,Igor Felipe P. Matos,Ana Liz P. Matos,Felipe R. Paranhos,Luiz Renato |
dc.subject.por.fl_str_mv |
neoplasms interleukins head and neck neoplasms oral squamous cell carcinoma |
topic |
neoplasms interleukins head and neck neoplasms oral squamous cell carcinoma |
description |
ABSTRACT Squamous cell carcinoma is a malignant neoplasm that affects the structures and tissues of the oral cavity. Interleukins (IL) synthesized from a tumor modulate a cascade reaction that may influence the prognosis of the disease. We aim to investigate in the literature whether interleukins are mediators that negatively or positively influence the prognosis of patients with oral squamous cell carcinoma. A systematic review study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) instructions. PubMed (including MedLine), Scopus, Web of Science, SciELO and Latin American and Caribbean Health Sciences (LILACS) databases were used as the primary sources for the study; OpenGrey and OpenThesis were used to search for "gray literature". The search conducted in seven general databases resulted in a set of 858 studies, while the search conducted in two databases for gray literature resulted in 82 studies, totaling 940 studies. From these, 15 studies were selected for this systematic review (eight studies presented low bias risk; four studies presented moderate bias risk; and three studies presented high risk of bias). Although they may act on the anti-tumor immune response pathways, the IL evaluated in the present systematic review (IL-4, IL-6, IL-8, IL-10, IL-12 and IL-13) tend to present a response associated with the intensification of carcinogenesis and poor prognosis in patients with oral squamous cell carcinoma. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000500550 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000500550 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/1676-2444.20190051 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial v.55 n.5 2019 reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) instname:Sociedade Brasileira de Patologia (SBP) instacron:SBP |
instname_str |
Sociedade Brasileira de Patologia (SBP) |
instacron_str |
SBP |
institution |
SBP |
reponame_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
collection |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP) |
repository.mail.fl_str_mv |
||jbpml@sbpc.org.br |
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1752122297521537024 |