Markers of acute-phase response in the treatment of pulmonary tuberculosis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000600428 |
Resumo: | Introduction:Tuberculosis promotes an acute phase response with an increase of blood reactants, such as C-reactive protein (CRP), among others, which are associated with increased erythrocyte sedimentation rate (ESR).Objective:Evaluate the ESR and the CRP as markers for diagnosis and monitoring cases of pulmonary tuberculosis.Method:Research on patients with clinical, laboratory, and imaging diagnosis of pulmonary tuberculosis, from Itajaí-SC; in which CRP and ESR were analyzed in three different times: at diagnosis, before starting treatment (T0), after three months of treatment (T1), and at the end of treatment (T2).Results:51 patients were studied at T0 (100%), 43 (84.31%) at T1, and 32 (62.74%) at T2. ESR and CRP values presented significant differences in the three different times (p < 0.0001***). When analyzing the relationship between negative/positive sputum and altered/normal ESR and CRP at T0, ESR (p = 0.0691), CRP (p = 0.0166*). For chest imaging and sputum smear variables it was observed the following: CRP versus smear (p = 0.0002***), ESR versus smear (p = 0.3810), CRP versus chest imaging (p = 0.0097**), and ESR versus chest imaging (p = 0.0766). The correlation between ESR and CRP was: T0 (p = 0.0033**), T1 (p < 0.0001***) and T2 (p = 0.0015**).Conclusion:ESR and CRP proved to be good markers in the diagnosis and monitoring of tuberculosis cases, however, CRP achieve more significant results than ESR. |
id |
SBP-1_863bd80a9d566fc57d331065e1621847 |
---|---|
oai_identifier_str |
oai:scielo:S1676-24442014000600428 |
network_acronym_str |
SBP-1 |
network_name_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository_id_str |
|
spelling |
Markers of acute-phase response in the treatment of pulmonary tuberculosispulmonary tuberculosisC-reactive proteinerythrocyte sedimentation rateIntroduction:Tuberculosis promotes an acute phase response with an increase of blood reactants, such as C-reactive protein (CRP), among others, which are associated with increased erythrocyte sedimentation rate (ESR).Objective:Evaluate the ESR and the CRP as markers for diagnosis and monitoring cases of pulmonary tuberculosis.Method:Research on patients with clinical, laboratory, and imaging diagnosis of pulmonary tuberculosis, from Itajaí-SC; in which CRP and ESR were analyzed in three different times: at diagnosis, before starting treatment (T0), after three months of treatment (T1), and at the end of treatment (T2).Results:51 patients were studied at T0 (100%), 43 (84.31%) at T1, and 32 (62.74%) at T2. ESR and CRP values presented significant differences in the three different times (p < 0.0001***). When analyzing the relationship between negative/positive sputum and altered/normal ESR and CRP at T0, ESR (p = 0.0691), CRP (p = 0.0166*). For chest imaging and sputum smear variables it was observed the following: CRP versus smear (p = 0.0002***), ESR versus smear (p = 0.3810), CRP versus chest imaging (p = 0.0097**), and ESR versus chest imaging (p = 0.0766). The correlation between ESR and CRP was: T0 (p = 0.0033**), T1 (p < 0.0001***) and T2 (p = 0.0015**).Conclusion:ESR and CRP proved to be good markers in the diagnosis and monitoring of tuberculosis cases, however, CRP achieve more significant results than ESR.Sociedade Brasileira de Patologia Clínica2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000600428Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.6 2014reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20140052info:eu-repo/semantics/openAccessMartins,CristianeGama,Antônio Carlos de CastroValcarenghi,DanielaBatschauer,Anna Paula de Borbaeng2015-10-27T00:00:00Zoai:scielo:S1676-24442014000600428Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2015-10-27T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false |
dc.title.none.fl_str_mv |
Markers of acute-phase response in the treatment of pulmonary tuberculosis |
title |
Markers of acute-phase response in the treatment of pulmonary tuberculosis |
spellingShingle |
Markers of acute-phase response in the treatment of pulmonary tuberculosis Martins,Cristiane pulmonary tuberculosis C-reactive protein erythrocyte sedimentation rate |
title_short |
Markers of acute-phase response in the treatment of pulmonary tuberculosis |
title_full |
Markers of acute-phase response in the treatment of pulmonary tuberculosis |
title_fullStr |
Markers of acute-phase response in the treatment of pulmonary tuberculosis |
title_full_unstemmed |
Markers of acute-phase response in the treatment of pulmonary tuberculosis |
title_sort |
Markers of acute-phase response in the treatment of pulmonary tuberculosis |
author |
Martins,Cristiane |
author_facet |
Martins,Cristiane Gama,Antônio Carlos de Castro Valcarenghi,Daniela Batschauer,Anna Paula de Borba |
author_role |
author |
author2 |
Gama,Antônio Carlos de Castro Valcarenghi,Daniela Batschauer,Anna Paula de Borba |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Martins,Cristiane Gama,Antônio Carlos de Castro Valcarenghi,Daniela Batschauer,Anna Paula de Borba |
dc.subject.por.fl_str_mv |
pulmonary tuberculosis C-reactive protein erythrocyte sedimentation rate |
topic |
pulmonary tuberculosis C-reactive protein erythrocyte sedimentation rate |
description |
Introduction:Tuberculosis promotes an acute phase response with an increase of blood reactants, such as C-reactive protein (CRP), among others, which are associated with increased erythrocyte sedimentation rate (ESR).Objective:Evaluate the ESR and the CRP as markers for diagnosis and monitoring cases of pulmonary tuberculosis.Method:Research on patients with clinical, laboratory, and imaging diagnosis of pulmonary tuberculosis, from Itajaí-SC; in which CRP and ESR were analyzed in three different times: at diagnosis, before starting treatment (T0), after three months of treatment (T1), and at the end of treatment (T2).Results:51 patients were studied at T0 (100%), 43 (84.31%) at T1, and 32 (62.74%) at T2. ESR and CRP values presented significant differences in the three different times (p < 0.0001***). When analyzing the relationship between negative/positive sputum and altered/normal ESR and CRP at T0, ESR (p = 0.0691), CRP (p = 0.0166*). For chest imaging and sputum smear variables it was observed the following: CRP versus smear (p = 0.0002***), ESR versus smear (p = 0.3810), CRP versus chest imaging (p = 0.0097**), and ESR versus chest imaging (p = 0.0766). The correlation between ESR and CRP was: T0 (p = 0.0033**), T1 (p < 0.0001***) and T2 (p = 0.0015**).Conclusion:ESR and CRP proved to be good markers in the diagnosis and monitoring of tuberculosis cases, however, CRP achieve more significant results than ESR. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000600428 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000600428 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/1676-2444.20140052 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.6 2014 reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) instname:Sociedade Brasileira de Patologia (SBP) instacron:SBP |
instname_str |
Sociedade Brasileira de Patologia (SBP) |
instacron_str |
SBP |
institution |
SBP |
reponame_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
collection |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP) |
repository.mail.fl_str_mv |
||jbpml@sbpc.org.br |
_version_ |
1752122296243322880 |