Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient

Detalhes bibliográficos
Autor(a) principal: Maranhão,Fernanda Cristina A
Data de Publicação: 2020
Outros Autores: Fonseca,Douglas L. H, Santos,Graciella S. A, Fonseca,Luisa Andrea V, Santos,Eduardo José L, Silva,Denise Maria W
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100704
Resumo: ABSTRACT Cryptococcosis is caused by yeasts of the Cryptococcus neoformans/C. gattii complex, presenting cutaneous, respiratory and disseminated forms. A 44-year-old immunocompetent male with facial lesion and latent pneumonia was hospitalized and misdiagnosed with paracoccidioidomycosis. Computerized tomography scans showed pulmonary and neurological involvement, and cultures/China ink, cryptococcal antigen test and restriction fragment length polymorphism of urease gene (URA5-RFLP) confirmed C. neoformans genotype VNI. Hemoculture indicated ampicillin-resistant Klebsiella pneumoniae (healthcare-associated infection). Fluconazole was administered, but after resistance detection, amphotericin B was chosen (cumulative dose/1500 mg). The patient was discharged with clinical remission (75 days) and amphotericin for one year (maintenance phase).
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spelling Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patientcryptococcosiscryptococcal meningitisCryptococcus neoformansamphotericin BKlebsiella pneumoniaeABSTRACT Cryptococcosis is caused by yeasts of the Cryptococcus neoformans/C. gattii complex, presenting cutaneous, respiratory and disseminated forms. A 44-year-old immunocompetent male with facial lesion and latent pneumonia was hospitalized and misdiagnosed with paracoccidioidomycosis. Computerized tomography scans showed pulmonary and neurological involvement, and cultures/China ink, cryptococcal antigen test and restriction fragment length polymorphism of urease gene (URA5-RFLP) confirmed C. neoformans genotype VNI. Hemoculture indicated ampicillin-resistant Klebsiella pneumoniae (healthcare-associated infection). Fluconazole was administered, but after resistance detection, amphotericin B was chosen (cumulative dose/1500 mg). The patient was discharged with clinical remission (75 days) and amphotericin for one year (maintenance phase).Sociedade Brasileira de Patologia Clínica2020-01-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100704Jornal Brasileiro de Patologia e Medicina Laboratorial v.56 2020reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20200017info:eu-repo/semantics/openAccessMaranhão,Fernanda Cristina AFonseca,Douglas L. HSantos,Graciella S. AFonseca,Luisa Andrea VSantos,Eduardo José LSilva,Denise Maria Weng2020-05-06T00:00:00Zoai:scielo:S1676-24442020000100704Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2020-05-06T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
title Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
spellingShingle Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
Maranhão,Fernanda Cristina A
cryptococcosis
cryptococcal meningitis
Cryptococcus neoformans
amphotericin B
Klebsiella pneumoniae
title_short Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
title_full Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
title_fullStr Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
title_full_unstemmed Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
title_sort Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
author Maranhão,Fernanda Cristina A
author_facet Maranhão,Fernanda Cristina A
Fonseca,Douglas L. H
Santos,Graciella S. A
Fonseca,Luisa Andrea V
Santos,Eduardo José L
Silva,Denise Maria W
author_role author
author2 Fonseca,Douglas L. H
Santos,Graciella S. A
Fonseca,Luisa Andrea V
Santos,Eduardo José L
Silva,Denise Maria W
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Maranhão,Fernanda Cristina A
Fonseca,Douglas L. H
Santos,Graciella S. A
Fonseca,Luisa Andrea V
Santos,Eduardo José L
Silva,Denise Maria W
dc.subject.por.fl_str_mv cryptococcosis
cryptococcal meningitis
Cryptococcus neoformans
amphotericin B
Klebsiella pneumoniae
topic cryptococcosis
cryptococcal meningitis
Cryptococcus neoformans
amphotericin B
Klebsiella pneumoniae
description ABSTRACT Cryptococcosis is caused by yeasts of the Cryptococcus neoformans/C. gattii complex, presenting cutaneous, respiratory and disseminated forms. A 44-year-old immunocompetent male with facial lesion and latent pneumonia was hospitalized and misdiagnosed with paracoccidioidomycosis. Computerized tomography scans showed pulmonary and neurological involvement, and cultures/China ink, cryptococcal antigen test and restriction fragment length polymorphism of urease gene (URA5-RFLP) confirmed C. neoformans genotype VNI. Hemoculture indicated ampicillin-resistant Klebsiella pneumoniae (healthcare-associated infection). Fluconazole was administered, but after resistance detection, amphotericin B was chosen (cumulative dose/1500 mg). The patient was discharged with clinical remission (75 days) and amphotericin for one year (maintenance phase).
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100704
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20200017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.56 2020
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
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reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
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