Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions

• Autor(a) principal: Gomes,Raylane P
• Data de Publicação: 2020
• Outros Autores: Caetano,Gabriela Tayrine, Sampaio,Lucas Henrique F, Silva,Camila R, Costa,Maurício B, Cysneiro,Maria Auxiliadora, Wastowski,Isabela Jubé
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100600
• topic: melanoma; HLA-G antigens; immunohistochemistry

ABSTRACT The human leukocyte antigen-G (HLA-G) is a non-classical molecule of the major histocompatibility complex. HLA-G has been associated with the process of tumorigenesis and tumor escape. In this study, we aim to evaluate the HLA-G expression in melanocytic lesions and in melanoma for determining when melanocytic lesions start its expression. Twenty-two skin biopsies samples were submitted to immunohistochemistry; HLA-G expression was detected in 63.6% of the samples. This expression in melanocytic cells was significantly higher in melanoma than in benign melanocytic lesions (p < 0.002). Our results suggest that HLA-G expression starts late in the process of tumorigenesis.