Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation

Detalhes bibliográficos
Autor(a) principal: Okamoto,Cristina T.
Data de Publicação: 2016
Outros Autores: Oldenburg Neto,Carlos F., Witkowski,Sandra Mara, Percicote,Ana Paula, Pasqualotto,Luca R., Troiano,Gabriela, Almeida,Tammy, Souza,Cleber M., Noronha,Lúcia de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442016000400253
Resumo: ABSTRACT INTRODUCTION: Chronic lung disease (CLD), clinically known as bronchopulmonary dysplasia (BPD), is a major cause of morbidity in premature newborn and were submitted to oxygen therapy. OBJECTIVE: Immunohistochemical identification of inflammatory molecules in the lung tissue of premature neonates that died with CLD. METHODS: Immunohistochemical analysis of 51 samples of premature newborn lungs – grouped in: without CLD,"classic" CLD and"new" CLD. RESULTS: Neutrophil influx and the number of CD4+ and CD45RO+ cells were higher in the"classic" CLD group (p < 0.001). CONCLUSION: Our findings suggest that the inflammatory response is mediated by neutrophils and CD45RO+ and CD4+ T lymphocytes in the"classic" CLD.
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spelling Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilationbronchopulmonary dysplasiaimmunochemistrypremature birthoxygen therapyneonatologyABSTRACT INTRODUCTION: Chronic lung disease (CLD), clinically known as bronchopulmonary dysplasia (BPD), is a major cause of morbidity in premature newborn and were submitted to oxygen therapy. OBJECTIVE: Immunohistochemical identification of inflammatory molecules in the lung tissue of premature neonates that died with CLD. METHODS: Immunohistochemical analysis of 51 samples of premature newborn lungs – grouped in: without CLD,"classic" CLD and"new" CLD. RESULTS: Neutrophil influx and the number of CD4+ and CD45RO+ cells were higher in the"classic" CLD group (p < 0.001). CONCLUSION: Our findings suggest that the inflammatory response is mediated by neutrophils and CD45RO+ and CD4+ T lymphocytes in the"classic" CLD.Sociedade Brasileira de Patologia Clínica2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442016000400253Jornal Brasileiro de Patologia e Medicina Laboratorial v.52 n.4 2016reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20160042info:eu-repo/semantics/openAccessOkamoto,Cristina T.Oldenburg Neto,Carlos F.Witkowski,Sandra MaraPercicote,Ana PaulaPasqualotto,Luca R.Troiano,GabrielaAlmeida,TammySouza,Cleber M.Noronha,Lúcia deeng2016-11-04T00:00:00Zoai:scielo:S1676-24442016000400253Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2016-11-04T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation
title Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation
spellingShingle Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation
Okamoto,Cristina T.
bronchopulmonary dysplasia
immunochemistry
premature birth
oxygen therapy
neonatology
title_short Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation
title_full Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation
title_fullStr Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation
title_full_unstemmed Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation
title_sort Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation
author Okamoto,Cristina T.
author_facet Okamoto,Cristina T.
Oldenburg Neto,Carlos F.
Witkowski,Sandra Mara
Percicote,Ana Paula
Pasqualotto,Luca R.
Troiano,Gabriela
Almeida,Tammy
Souza,Cleber M.
Noronha,Lúcia de
author_role author
author2 Oldenburg Neto,Carlos F.
Witkowski,Sandra Mara
Percicote,Ana Paula
Pasqualotto,Luca R.
Troiano,Gabriela
Almeida,Tammy
Souza,Cleber M.
Noronha,Lúcia de
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Okamoto,Cristina T.
Oldenburg Neto,Carlos F.
Witkowski,Sandra Mara
Percicote,Ana Paula
Pasqualotto,Luca R.
Troiano,Gabriela
Almeida,Tammy
Souza,Cleber M.
Noronha,Lúcia de
dc.subject.por.fl_str_mv bronchopulmonary dysplasia
immunochemistry
premature birth
oxygen therapy
neonatology
topic bronchopulmonary dysplasia
immunochemistry
premature birth
oxygen therapy
neonatology
description ABSTRACT INTRODUCTION: Chronic lung disease (CLD), clinically known as bronchopulmonary dysplasia (BPD), is a major cause of morbidity in premature newborn and were submitted to oxygen therapy. OBJECTIVE: Immunohistochemical identification of inflammatory molecules in the lung tissue of premature neonates that died with CLD. METHODS: Immunohistochemical analysis of 51 samples of premature newborn lungs – grouped in: without CLD,"classic" CLD and"new" CLD. RESULTS: Neutrophil influx and the number of CD4+ and CD45RO+ cells were higher in the"classic" CLD group (p < 0.001). CONCLUSION: Our findings suggest that the inflammatory response is mediated by neutrophils and CD45RO+ and CD4+ T lymphocytes in the"classic" CLD.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442016000400253
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442016000400253
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20160042
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.52 n.4 2016
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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