Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572017000300274 |
Resumo: | Abstract Objectives: To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. Methods: This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening database for all live births from January 1, 2010, to December 31, 2012, assessed using the Newborn Screening Program of a Brazilian state, Brazil. The infants were divided into two groups: I - Control: infants with normal newborn screening tests and II - Study: infants with congenital hypothyroidism. Analysis included comparing the TSHneo levels from both groups. A receiver operating characteristic (ROC) curve was constructed to assess the TSHneo cutoff values. Results: Using a TSHneo cutoff value of 5.0 µIU/mL, 50 out of 111,705 screened infants had diagnosis of congenital hypothyroidism (prevalence 1:2234 live births). The ROC curve showed that TSHneo value of 5.03 µIU/mL had 100% sensitivity and the greatest associated specificity (93.7%). The area under the curve was 0.9898 (p < 0.0001). Conclusions: The ROC curve confirmed that the TSHneo cutoff value of 5.0 µIU/mL adopted by the Newborn Screening Program of a Brazilian state was the most appropriate for detecting congenital hypothyroidism and most likely explains the high prevalence that was found. |
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Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff valuesCongenital hypothyroidismNewborn screeningNeonatal screeningThyrotropinAbstract Objectives: To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. Methods: This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening database for all live births from January 1, 2010, to December 31, 2012, assessed using the Newborn Screening Program of a Brazilian state, Brazil. The infants were divided into two groups: I - Control: infants with normal newborn screening tests and II - Study: infants with congenital hypothyroidism. Analysis included comparing the TSHneo levels from both groups. A receiver operating characteristic (ROC) curve was constructed to assess the TSHneo cutoff values. Results: Using a TSHneo cutoff value of 5.0 µIU/mL, 50 out of 111,705 screened infants had diagnosis of congenital hypothyroidism (prevalence 1:2234 live births). The ROC curve showed that TSHneo value of 5.03 µIU/mL had 100% sensitivity and the greatest associated specificity (93.7%). The area under the curve was 0.9898 (p < 0.0001). Conclusions: The ROC curve confirmed that the TSHneo cutoff value of 5.0 µIU/mL adopted by the Newborn Screening Program of a Brazilian state was the most appropriate for detecting congenital hypothyroidism and most likely explains the high prevalence that was found.Sociedade Brasileira de Pediatria2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572017000300274Jornal de Pediatria v.93 n.3 2017reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2016.07.006info:eu-repo/semantics/openAccessSilvestrin,Stela MarisLeone,ClaudioLeone,Cléa Rodrigueseng2017-06-02T00:00:00Zoai:scielo:S0021-75572017000300274Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2017-06-02T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values |
title |
Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values |
spellingShingle |
Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values Silvestrin,Stela Maris Congenital hypothyroidism Newborn screening Neonatal screening Thyrotropin |
title_short |
Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values |
title_full |
Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values |
title_fullStr |
Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values |
title_full_unstemmed |
Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values |
title_sort |
Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values |
author |
Silvestrin,Stela Maris |
author_facet |
Silvestrin,Stela Maris Leone,Claudio Leone,Cléa Rodrigues |
author_role |
author |
author2 |
Leone,Claudio Leone,Cléa Rodrigues |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Silvestrin,Stela Maris Leone,Claudio Leone,Cléa Rodrigues |
dc.subject.por.fl_str_mv |
Congenital hypothyroidism Newborn screening Neonatal screening Thyrotropin |
topic |
Congenital hypothyroidism Newborn screening Neonatal screening Thyrotropin |
description |
Abstract Objectives: To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. Methods: This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening database for all live births from January 1, 2010, to December 31, 2012, assessed using the Newborn Screening Program of a Brazilian state, Brazil. The infants were divided into two groups: I - Control: infants with normal newborn screening tests and II - Study: infants with congenital hypothyroidism. Analysis included comparing the TSHneo levels from both groups. A receiver operating characteristic (ROC) curve was constructed to assess the TSHneo cutoff values. Results: Using a TSHneo cutoff value of 5.0 µIU/mL, 50 out of 111,705 screened infants had diagnosis of congenital hypothyroidism (prevalence 1:2234 live births). The ROC curve showed that TSHneo value of 5.03 µIU/mL had 100% sensitivity and the greatest associated specificity (93.7%). The area under the curve was 0.9898 (p < 0.0001). Conclusions: The ROC curve confirmed that the TSHneo cutoff value of 5.0 µIU/mL adopted by the Newborn Screening Program of a Brazilian state was the most appropriate for detecting congenital hypothyroidism and most likely explains the high prevalence that was found. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572017000300274 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572017000300274 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2016.07.006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.93 n.3 2017 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
_version_ |
1752122320964550656 |