Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values

Detalhes bibliográficos
Autor(a) principal: Silvestrin,Stela Maris
Data de Publicação: 2017
Outros Autores: Leone,Claudio, Leone,Cléa Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal de Pediatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572017000300274
Resumo: Abstract Objectives: To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. Methods: This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening database for all live births from January 1, 2010, to December 31, 2012, assessed using the Newborn Screening Program of a Brazilian state, Brazil. The infants were divided into two groups: I - Control: infants with normal newborn screening tests and II - Study: infants with congenital hypothyroidism. Analysis included comparing the TSHneo levels from both groups. A receiver operating characteristic (ROC) curve was constructed to assess the TSHneo cutoff values. Results: Using a TSHneo cutoff value of 5.0 µIU/mL, 50 out of 111,705 screened infants had diagnosis of congenital hypothyroidism (prevalence 1:2234 live births). The ROC curve showed that TSHneo value of 5.03 µIU/mL had 100% sensitivity and the greatest associated specificity (93.7%). The area under the curve was 0.9898 (p < 0.0001). Conclusions: The ROC curve confirmed that the TSHneo cutoff value of 5.0 µIU/mL adopted by the Newborn Screening Program of a Brazilian state was the most appropriate for detecting congenital hypothyroidism and most likely explains the high prevalence that was found.
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spelling Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff valuesCongenital hypothyroidismNewborn screeningNeonatal screeningThyrotropinAbstract Objectives: To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. Methods: This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening database for all live births from January 1, 2010, to December 31, 2012, assessed using the Newborn Screening Program of a Brazilian state, Brazil. The infants were divided into two groups: I - Control: infants with normal newborn screening tests and II - Study: infants with congenital hypothyroidism. Analysis included comparing the TSHneo levels from both groups. A receiver operating characteristic (ROC) curve was constructed to assess the TSHneo cutoff values. Results: Using a TSHneo cutoff value of 5.0 µIU/mL, 50 out of 111,705 screened infants had diagnosis of congenital hypothyroidism (prevalence 1:2234 live births). The ROC curve showed that TSHneo value of 5.03 µIU/mL had 100% sensitivity and the greatest associated specificity (93.7%). The area under the curve was 0.9898 (p < 0.0001). Conclusions: The ROC curve confirmed that the TSHneo cutoff value of 5.0 µIU/mL adopted by the Newborn Screening Program of a Brazilian state was the most appropriate for detecting congenital hypothyroidism and most likely explains the high prevalence that was found.Sociedade Brasileira de Pediatria2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572017000300274Jornal de Pediatria v.93 n.3 2017reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2016.07.006info:eu-repo/semantics/openAccessSilvestrin,Stela MarisLeone,ClaudioLeone,Cléa Rodrigueseng2017-06-02T00:00:00Zoai:scielo:S0021-75572017000300274Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2017-06-02T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false
dc.title.none.fl_str_mv Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values
title Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values
spellingShingle Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values
Silvestrin,Stela Maris
Congenital hypothyroidism
Newborn screening
Neonatal screening
Thyrotropin
title_short Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values
title_full Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values
title_fullStr Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values
title_full_unstemmed Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values
title_sort Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values
author Silvestrin,Stela Maris
author_facet Silvestrin,Stela Maris
Leone,Claudio
Leone,Cléa Rodrigues
author_role author
author2 Leone,Claudio
Leone,Cléa Rodrigues
author2_role author
author
dc.contributor.author.fl_str_mv Silvestrin,Stela Maris
Leone,Claudio
Leone,Cléa Rodrigues
dc.subject.por.fl_str_mv Congenital hypothyroidism
Newborn screening
Neonatal screening
Thyrotropin
topic Congenital hypothyroidism
Newborn screening
Neonatal screening
Thyrotropin
description Abstract Objectives: To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. Methods: This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening database for all live births from January 1, 2010, to December 31, 2012, assessed using the Newborn Screening Program of a Brazilian state, Brazil. The infants were divided into two groups: I - Control: infants with normal newborn screening tests and II - Study: infants with congenital hypothyroidism. Analysis included comparing the TSHneo levels from both groups. A receiver operating characteristic (ROC) curve was constructed to assess the TSHneo cutoff values. Results: Using a TSHneo cutoff value of 5.0 µIU/mL, 50 out of 111,705 screened infants had diagnosis of congenital hypothyroidism (prevalence 1:2234 live births). The ROC curve showed that TSHneo value of 5.03 µIU/mL had 100% sensitivity and the greatest associated specificity (93.7%). The area under the curve was 0.9898 (p < 0.0001). Conclusions: The ROC curve confirmed that the TSHneo cutoff value of 5.0 µIU/mL adopted by the Newborn Screening Program of a Brazilian state was the most appropriate for detecting congenital hypothyroidism and most likely explains the high prevalence that was found.
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572017000300274
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572017000300274
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jped.2016.07.006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Jornal de Pediatria v.93 n.3 2017
reponame:Jornal de Pediatria (Online)
instname:Sociedade Brasileira de Pediatria (SBP)
instacron:SBPE
instname_str Sociedade Brasileira de Pediatria (SBP)
instacron_str SBPE
institution SBPE
reponame_str Jornal de Pediatria (Online)
collection Jornal de Pediatria (Online)
repository.name.fl_str_mv Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)
repository.mail.fl_str_mv ||jped@jped.com.br
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