Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000400413 |
Resumo: | Abstract Objective: Suspicion of early anterior fontanel (AF) closure is a common reason for referral to a pediatric neurosurgeon because of the suspected increased risk of developing craniosynostosis (CS) in spite of the absence of evidence in the literature. The aim of this study was to analyze the association between AF closure and the diagnosis of non-syndromic CS in Brazilian children. Methods: An observational and case-cohort study was conducted to compare the incidence of closed AF between healthy children (group 1) and children diagnosed with non-syndromic CS (group 2) at a pediatric neurosurgery referral center. The accuracies of completely closed AF and diagnosis of CS were assessed. Results: High-resolution three-dimensional reconstruction computed tomography scans were obtained for 140 children aged < 13 months, of whom 62.9% were boys and 37.1% were girls (p < 0.001). The most common types of non-syndromic CS were trigonocephaly (34, 48%) and scaphocephaly (25, 35.7%). Closed fontanel (27, 38.6%) was observed in both groups, and a sensitivity of 36.1%, specificity of 72%, the positive predictive value of 59%, and negative predictive value of 51% were observed in the patients diagnosed with CS when AF closure occurred before the age of 6 months. Conclusion: The results of this comparative study of AF closure and CS diagnosis suggest that early AF closure does not imply a diagnosis of CS. Pediatricians should be aware of the risk of misdiagnosis of CS in cases with a widely open AF in spite of the presence of CS. |
id |
SBPE-1_94f3f3723deea5dd285d1407a7bae95a |
---|---|
oai_identifier_str |
oai:scielo:S0021-75572022000400413 |
network_acronym_str |
SBPE-1 |
network_name_str |
Jornal de Pediatria (Online) |
repository_id_str |
|
spelling |
Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomographyAnterior fontanelComputed tomographySutureCraniosynostosisGrowth and developmentAbstract Objective: Suspicion of early anterior fontanel (AF) closure is a common reason for referral to a pediatric neurosurgeon because of the suspected increased risk of developing craniosynostosis (CS) in spite of the absence of evidence in the literature. The aim of this study was to analyze the association between AF closure and the diagnosis of non-syndromic CS in Brazilian children. Methods: An observational and case-cohort study was conducted to compare the incidence of closed AF between healthy children (group 1) and children diagnosed with non-syndromic CS (group 2) at a pediatric neurosurgery referral center. The accuracies of completely closed AF and diagnosis of CS were assessed. Results: High-resolution three-dimensional reconstruction computed tomography scans were obtained for 140 children aged < 13 months, of whom 62.9% were boys and 37.1% were girls (p < 0.001). The most common types of non-syndromic CS were trigonocephaly (34, 48%) and scaphocephaly (25, 35.7%). Closed fontanel (27, 38.6%) was observed in both groups, and a sensitivity of 36.1%, specificity of 72%, the positive predictive value of 59%, and negative predictive value of 51% were observed in the patients diagnosed with CS when AF closure occurred before the age of 6 months. Conclusion: The results of this comparative study of AF closure and CS diagnosis suggest that early AF closure does not imply a diagnosis of CS. Pediatricians should be aware of the risk of misdiagnosis of CS in cases with a widely open AF in spite of the presence of CS.Sociedade Brasileira de Pediatria2022-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000400413Jornal de Pediatria v.98 n.4 2022reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2021.10.004info:eu-repo/semantics/openAccessFurtado,Leopoldo Mandic FerreiraCosta Val Filho,José Aloysio daFreitas,Letícia SilveiraSantos,Aieska Kellen Dantas doseng2022-07-20T00:00:00Zoai:scielo:S0021-75572022000400413Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2022-07-20T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography |
title |
Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography |
spellingShingle |
Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography Furtado,Leopoldo Mandic Ferreira Anterior fontanel Computed tomography Suture Craniosynostosis Growth and development |
title_short |
Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography |
title_full |
Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography |
title_fullStr |
Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography |
title_full_unstemmed |
Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography |
title_sort |
Anterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography |
author |
Furtado,Leopoldo Mandic Ferreira |
author_facet |
Furtado,Leopoldo Mandic Ferreira Costa Val Filho,José Aloysio da Freitas,Letícia Silveira Santos,Aieska Kellen Dantas dos |
author_role |
author |
author2 |
Costa Val Filho,José Aloysio da Freitas,Letícia Silveira Santos,Aieska Kellen Dantas dos |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Furtado,Leopoldo Mandic Ferreira Costa Val Filho,José Aloysio da Freitas,Letícia Silveira Santos,Aieska Kellen Dantas dos |
dc.subject.por.fl_str_mv |
Anterior fontanel Computed tomography Suture Craniosynostosis Growth and development |
topic |
Anterior fontanel Computed tomography Suture Craniosynostosis Growth and development |
description |
Abstract Objective: Suspicion of early anterior fontanel (AF) closure is a common reason for referral to a pediatric neurosurgeon because of the suspected increased risk of developing craniosynostosis (CS) in spite of the absence of evidence in the literature. The aim of this study was to analyze the association between AF closure and the diagnosis of non-syndromic CS in Brazilian children. Methods: An observational and case-cohort study was conducted to compare the incidence of closed AF between healthy children (group 1) and children diagnosed with non-syndromic CS (group 2) at a pediatric neurosurgery referral center. The accuracies of completely closed AF and diagnosis of CS were assessed. Results: High-resolution three-dimensional reconstruction computed tomography scans were obtained for 140 children aged < 13 months, of whom 62.9% were boys and 37.1% were girls (p < 0.001). The most common types of non-syndromic CS were trigonocephaly (34, 48%) and scaphocephaly (25, 35.7%). Closed fontanel (27, 38.6%) was observed in both groups, and a sensitivity of 36.1%, specificity of 72%, the positive predictive value of 59%, and negative predictive value of 51% were observed in the patients diagnosed with CS when AF closure occurred before the age of 6 months. Conclusion: The results of this comparative study of AF closure and CS diagnosis suggest that early AF closure does not imply a diagnosis of CS. Pediatricians should be aware of the risk of misdiagnosis of CS in cases with a widely open AF in spite of the presence of CS. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000400413 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000400413 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2021.10.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.98 n.4 2022 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
_version_ |
1752122323326992384 |