Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000500466 |
Resumo: | Abstract Objectives: To describe aspects of the microcephaly epidemic in the state of Piauí. Methods: All cases of congenital microcephaly confirmed in the state between 2015 and 2016 were included (n = 100). Investigation forms of the Regional Reference Center for Microcephaly were reviewed. Discarded cases (n = 63) were used as a comparison group. Results: In October, November, and December 2015 incidence rates reached 4.46, 6.33 and 3.86/1000 live births, respectively; 44 cases were reported in the state capital. Among the mothers of confirmed and discarded cases, the frequency of skin rash during pregnancy was 50/97 (51.5%) and 8/51 (15.7%), respectively (p < 0.001); 33 confirmed cases (35.9%) had a head circumference z-score between −2 and −3, 23 (25%) between −3 and −4, and 8 (8.7%) had a z-score of less than −4. Head computer tomography scans revealed calcifications in 78/95 (82.1%) cases. Lissencephaly, hydrocephalus and agenesis of the corpus callosum were also frequently observed. Ophthalmic findings included retinal pigment epithelium rarefaction and atrophy. Absence of otoacoustic emissions was observed in 21/70 cases. One newborn also presented lower limb muscle atrophy. There were no significant differences in vaccination rates for influenza, diphtheria-tetanus-acellular pertussis, and hepatitis B in either group. Conclusions: The state of Piauí, like others in the northeastern region, faced an epidemic of congenital microcephaly between 2015 and 2016, presumably related to congenital Zika virus infection, more intense in the capital. Current challenges include the improvement of vector control, basic research, scaling-up of diagnostic tools for pre-natal screening of Zika virus, vaccines, and health care for affected children. |
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Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166MicrocephalyInfantsZikaState of PiauíAbstract Objectives: To describe aspects of the microcephaly epidemic in the state of Piauí. Methods: All cases of congenital microcephaly confirmed in the state between 2015 and 2016 were included (n = 100). Investigation forms of the Regional Reference Center for Microcephaly were reviewed. Discarded cases (n = 63) were used as a comparison group. Results: In October, November, and December 2015 incidence rates reached 4.46, 6.33 and 3.86/1000 live births, respectively; 44 cases were reported in the state capital. Among the mothers of confirmed and discarded cases, the frequency of skin rash during pregnancy was 50/97 (51.5%) and 8/51 (15.7%), respectively (p < 0.001); 33 confirmed cases (35.9%) had a head circumference z-score between −2 and −3, 23 (25%) between −3 and −4, and 8 (8.7%) had a z-score of less than −4. Head computer tomography scans revealed calcifications in 78/95 (82.1%) cases. Lissencephaly, hydrocephalus and agenesis of the corpus callosum were also frequently observed. Ophthalmic findings included retinal pigment epithelium rarefaction and atrophy. Absence of otoacoustic emissions was observed in 21/70 cases. One newborn also presented lower limb muscle atrophy. There were no significant differences in vaccination rates for influenza, diphtheria-tetanus-acellular pertussis, and hepatitis B in either group. Conclusions: The state of Piauí, like others in the northeastern region, faced an epidemic of congenital microcephaly between 2015 and 2016, presumably related to congenital Zika virus infection, more intense in the capital. Current challenges include the improvement of vector control, basic research, scaling-up of diagnostic tools for pre-natal screening of Zika virus, vaccines, and health care for affected children.Sociedade Brasileira de Pediatria2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000500466Jornal de Pediatria v.95 n.4 2019reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2018.04.013info:eu-repo/semantics/openAccessAlmeida,Isabel Marlúcia Lopes Moreira deRamos,Carmen VianaRodrigues,Danielle CarvalhoSousa,Amanda Carvalho deNascimento,Maria de Lourdes Cristina Alcântara Paz Carvalho doSilva,Marcos Vilhena Bittencourt daBatista,Francisca Miriane AraújoSantos,Jéssica Pereira dosOliveira,Roselane Sampaio deSoares,Filipe Augusto de FreitasXavier,Samanta Cristina das ChagasCarvalho-Costa,Filipe Anibaleng2019-09-09T00:00:00Zoai:scielo:S0021-75572019000500466Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2019-09-09T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166 |
title |
Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166 |
spellingShingle |
Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166 Almeida,Isabel Marlúcia Lopes Moreira de Microcephaly Infants Zika State of Piauí |
title_short |
Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166 |
title_full |
Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166 |
title_fullStr |
Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166 |
title_full_unstemmed |
Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166 |
title_sort |
Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-20166 |
author |
Almeida,Isabel Marlúcia Lopes Moreira de |
author_facet |
Almeida,Isabel Marlúcia Lopes Moreira de Ramos,Carmen Viana Rodrigues,Danielle Carvalho Sousa,Amanda Carvalho de Nascimento,Maria de Lourdes Cristina Alcântara Paz Carvalho do Silva,Marcos Vilhena Bittencourt da Batista,Francisca Miriane Araújo Santos,Jéssica Pereira dos Oliveira,Roselane Sampaio de Soares,Filipe Augusto de Freitas Xavier,Samanta Cristina das Chagas Carvalho-Costa,Filipe Anibal |
author_role |
author |
author2 |
Ramos,Carmen Viana Rodrigues,Danielle Carvalho Sousa,Amanda Carvalho de Nascimento,Maria de Lourdes Cristina Alcântara Paz Carvalho do Silva,Marcos Vilhena Bittencourt da Batista,Francisca Miriane Araújo Santos,Jéssica Pereira dos Oliveira,Roselane Sampaio de Soares,Filipe Augusto de Freitas Xavier,Samanta Cristina das Chagas Carvalho-Costa,Filipe Anibal |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Almeida,Isabel Marlúcia Lopes Moreira de Ramos,Carmen Viana Rodrigues,Danielle Carvalho Sousa,Amanda Carvalho de Nascimento,Maria de Lourdes Cristina Alcântara Paz Carvalho do Silva,Marcos Vilhena Bittencourt da Batista,Francisca Miriane Araújo Santos,Jéssica Pereira dos Oliveira,Roselane Sampaio de Soares,Filipe Augusto de Freitas Xavier,Samanta Cristina das Chagas Carvalho-Costa,Filipe Anibal |
dc.subject.por.fl_str_mv |
Microcephaly Infants Zika State of Piauí |
topic |
Microcephaly Infants Zika State of Piauí |
description |
Abstract Objectives: To describe aspects of the microcephaly epidemic in the state of Piauí. Methods: All cases of congenital microcephaly confirmed in the state between 2015 and 2016 were included (n = 100). Investigation forms of the Regional Reference Center for Microcephaly were reviewed. Discarded cases (n = 63) were used as a comparison group. Results: In October, November, and December 2015 incidence rates reached 4.46, 6.33 and 3.86/1000 live births, respectively; 44 cases were reported in the state capital. Among the mothers of confirmed and discarded cases, the frequency of skin rash during pregnancy was 50/97 (51.5%) and 8/51 (15.7%), respectively (p < 0.001); 33 confirmed cases (35.9%) had a head circumference z-score between −2 and −3, 23 (25%) between −3 and −4, and 8 (8.7%) had a z-score of less than −4. Head computer tomography scans revealed calcifications in 78/95 (82.1%) cases. Lissencephaly, hydrocephalus and agenesis of the corpus callosum were also frequently observed. Ophthalmic findings included retinal pigment epithelium rarefaction and atrophy. Absence of otoacoustic emissions was observed in 21/70 cases. One newborn also presented lower limb muscle atrophy. There were no significant differences in vaccination rates for influenza, diphtheria-tetanus-acellular pertussis, and hepatitis B in either group. Conclusions: The state of Piauí, like others in the northeastern region, faced an epidemic of congenital microcephaly between 2015 and 2016, presumably related to congenital Zika virus infection, more intense in the capital. Current challenges include the improvement of vector control, basic research, scaling-up of diagnostic tools for pre-natal screening of Zika virus, vaccines, and health care for affected children. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000500466 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000500466 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2018.04.013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.95 n.4 2019 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
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SBPE |
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SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
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Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
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||jped@jped.com.br |
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1752122321886248960 |