Eosinophilic esophagitis-Where are we today?,

Detalhes bibliográficos
Autor(a) principal: Ferreira,Cristina Targa
Data de Publicação: 2019
Outros Autores: Vieira,Mario Cesar, Furuta,Glenn T., Barros,Fernando Celso Lopes Fernandes de, Chehade,Mirna
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal de Pediatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000400275
Resumo: Abstract Objective: The objective of this review is to provide an overview of the practical diagnostic and therapeutic approaches to eosinophilic esophagitis and to increase the visibility of the disease among pediatricians. Sources: A search of the MEDLINE, Embase, and CINAHL databases and recent consensus statements and guidelines were performed. Summary of the findings: The definition of eosinophilic esophagitis is based on symptoms and histology. It is important to rule out other diseases associated with esophageal eosinophil-predominant inflammation. It is not yet clear whether the increased prevalence is due to a real increase in incidence or a result of increased awareness of the disease. Various options for management have been used in pediatric patients, including proton pump inhibitors, dietary restriction therapies, swallowed topical steroids, and endoscopic dilations. More recently, proton pump inhibitor-responsive esophageal eosinophilia and eosinophilic esophagitis have been contemplated on the same spectrum, and proton pump inhibitors should be considered the initial step in the treatment of these patients. Conclusions: Eosinophilic esophagitis is a relatively new disease with a remarkable progression of its incidence and prevalence in the past two to three decades, and diagnostic criteria that are constantly evolving. It is important to better understand the pathogenesis of the disease, the predisposing factors, the natural history, and the categorization of varying phenotypes to develop diagnostic and therapeutic strategies that meet the clinical needs of patients.
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spelling Eosinophilic esophagitis-Where are we today?,Eosinophilic esophagitisEsophageal eosinophiliaEosinophilicProton pump inhibitorsAbstract Objective: The objective of this review is to provide an overview of the practical diagnostic and therapeutic approaches to eosinophilic esophagitis and to increase the visibility of the disease among pediatricians. Sources: A search of the MEDLINE, Embase, and CINAHL databases and recent consensus statements and guidelines were performed. Summary of the findings: The definition of eosinophilic esophagitis is based on symptoms and histology. It is important to rule out other diseases associated with esophageal eosinophil-predominant inflammation. It is not yet clear whether the increased prevalence is due to a real increase in incidence or a result of increased awareness of the disease. Various options for management have been used in pediatric patients, including proton pump inhibitors, dietary restriction therapies, swallowed topical steroids, and endoscopic dilations. More recently, proton pump inhibitor-responsive esophageal eosinophilia and eosinophilic esophagitis have been contemplated on the same spectrum, and proton pump inhibitors should be considered the initial step in the treatment of these patients. Conclusions: Eosinophilic esophagitis is a relatively new disease with a remarkable progression of its incidence and prevalence in the past two to three decades, and diagnostic criteria that are constantly evolving. It is important to better understand the pathogenesis of the disease, the predisposing factors, the natural history, and the categorization of varying phenotypes to develop diagnostic and therapeutic strategies that meet the clinical needs of patients.Sociedade Brasileira de Pediatria2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000400275Jornal de Pediatria v.95 n.3 2019reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2018.06.012info:eu-repo/semantics/openAccessFerreira,Cristina TargaVieira,Mario CesarFuruta,Glenn T.Barros,Fernando Celso Lopes Fernandes deChehade,Mirnaeng2019-06-26T00:00:00Zoai:scielo:S0021-75572019000400275Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2019-06-26T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false
dc.title.none.fl_str_mv Eosinophilic esophagitis-Where are we today?,
title Eosinophilic esophagitis-Where are we today?,
spellingShingle Eosinophilic esophagitis-Where are we today?,
Ferreira,Cristina Targa
Eosinophilic esophagitis
Esophageal eosinophilia
Eosinophilic
Proton pump inhibitors
title_short Eosinophilic esophagitis-Where are we today?,
title_full Eosinophilic esophagitis-Where are we today?,
title_fullStr Eosinophilic esophagitis-Where are we today?,
title_full_unstemmed Eosinophilic esophagitis-Where are we today?,
title_sort Eosinophilic esophagitis-Where are we today?,
author Ferreira,Cristina Targa
author_facet Ferreira,Cristina Targa
Vieira,Mario Cesar
Furuta,Glenn T.
Barros,Fernando Celso Lopes Fernandes de
Chehade,Mirna
author_role author
author2 Vieira,Mario Cesar
Furuta,Glenn T.
Barros,Fernando Celso Lopes Fernandes de
Chehade,Mirna
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ferreira,Cristina Targa
Vieira,Mario Cesar
Furuta,Glenn T.
Barros,Fernando Celso Lopes Fernandes de
Chehade,Mirna
dc.subject.por.fl_str_mv Eosinophilic esophagitis
Esophageal eosinophilia
Eosinophilic
Proton pump inhibitors
topic Eosinophilic esophagitis
Esophageal eosinophilia
Eosinophilic
Proton pump inhibitors
description Abstract Objective: The objective of this review is to provide an overview of the practical diagnostic and therapeutic approaches to eosinophilic esophagitis and to increase the visibility of the disease among pediatricians. Sources: A search of the MEDLINE, Embase, and CINAHL databases and recent consensus statements and guidelines were performed. Summary of the findings: The definition of eosinophilic esophagitis is based on symptoms and histology. It is important to rule out other diseases associated with esophageal eosinophil-predominant inflammation. It is not yet clear whether the increased prevalence is due to a real increase in incidence or a result of increased awareness of the disease. Various options for management have been used in pediatric patients, including proton pump inhibitors, dietary restriction therapies, swallowed topical steroids, and endoscopic dilations. More recently, proton pump inhibitor-responsive esophageal eosinophilia and eosinophilic esophagitis have been contemplated on the same spectrum, and proton pump inhibitors should be considered the initial step in the treatment of these patients. Conclusions: Eosinophilic esophagitis is a relatively new disease with a remarkable progression of its incidence and prevalence in the past two to three decades, and diagnostic criteria that are constantly evolving. It is important to better understand the pathogenesis of the disease, the predisposing factors, the natural history, and the categorization of varying phenotypes to develop diagnostic and therapeutic strategies that meet the clinical needs of patients.
publishDate 2019
dc.date.none.fl_str_mv 2019-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000400275
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000400275
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jped.2018.06.012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Jornal de Pediatria v.95 n.3 2019
reponame:Jornal de Pediatria (Online)
instname:Sociedade Brasileira de Pediatria (SBP)
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instname_str Sociedade Brasileira de Pediatria (SBP)
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reponame_str Jornal de Pediatria (Online)
collection Jornal de Pediatria (Online)
repository.name.fl_str_mv Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)
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