A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000200161 |
Resumo: | OBJECTIVE:the low degree of inflammation in obesity contributes to systemic metabolic dysfunction. Recent experimental studies proposed some effects of alteration in gut microbiota on inflammatory factors. This study aimed to assess the anti-inflammatory effects of a synbiotic supplement on inflammation markers in overweight and obese children and adolescents.METHODS:this randomized triple-masked controlled trial was conducted among 70 participants aged 6 to 18 years, with a body mass index (BMI) equal or higher than the 85th percentile. They were randomly assigned into two groups of equal number to receive synbiotic or placebo for eight weeks.RESULTS:fifty-six of 70 participants (80%) completed the study. Compared with the placebo group, the synbiotic group had significant decrease in mean values of tumor necrosis-α and interleukin-6, with significant increase in adiponectin; these changes were no longer significant after adjustment for BMI. There was no significant change in the mean values of high-sensitive C-reactive protein.CONCLUSION:the present findings suggest the positive influence of synbiotic supplementation on inflammation factors, which are dependent to its effect on weight reduction in overweight and obese children. |
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Jornal de Pediatria (Online) |
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A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight childrenSynbioticChildren and adolescentsObesityInflammationTrialOBJECTIVE:the low degree of inflammation in obesity contributes to systemic metabolic dysfunction. Recent experimental studies proposed some effects of alteration in gut microbiota on inflammatory factors. This study aimed to assess the anti-inflammatory effects of a synbiotic supplement on inflammation markers in overweight and obese children and adolescents.METHODS:this randomized triple-masked controlled trial was conducted among 70 participants aged 6 to 18 years, with a body mass index (BMI) equal or higher than the 85th percentile. They were randomly assigned into two groups of equal number to receive synbiotic or placebo for eight weeks.RESULTS:fifty-six of 70 participants (80%) completed the study. Compared with the placebo group, the synbiotic group had significant decrease in mean values of tumor necrosis-α and interleukin-6, with significant increase in adiponectin; these changes were no longer significant after adjustment for BMI. There was no significant change in the mean values of high-sensitive C-reactive protein.CONCLUSION:the present findings suggest the positive influence of synbiotic supplementation on inflammation factors, which are dependent to its effect on weight reduction in overweight and obese children.Sociedade Brasileira de Pediatria2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000200161Jornal de Pediatria v.90 n.2 2014reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2013.07.003info:eu-repo/semantics/openAccessKelishadi,RoyaFarajian,SanamSafavi,MortezaMirlohi,MaryamHashemipour,Mahineng2015-10-08T00:00:00Zoai:scielo:S0021-75572014000200161Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2015-10-08T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children |
title |
A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children |
spellingShingle |
A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children Kelishadi,Roya Synbiotic Children and adolescents Obesity Inflammation Trial |
title_short |
A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children |
title_full |
A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children |
title_fullStr |
A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children |
title_full_unstemmed |
A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children |
title_sort |
A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children |
author |
Kelishadi,Roya |
author_facet |
Kelishadi,Roya Farajian,Sanam Safavi,Morteza Mirlohi,Maryam Hashemipour,Mahin |
author_role |
author |
author2 |
Farajian,Sanam Safavi,Morteza Mirlohi,Maryam Hashemipour,Mahin |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Kelishadi,Roya Farajian,Sanam Safavi,Morteza Mirlohi,Maryam Hashemipour,Mahin |
dc.subject.por.fl_str_mv |
Synbiotic Children and adolescents Obesity Inflammation Trial |
topic |
Synbiotic Children and adolescents Obesity Inflammation Trial |
description |
OBJECTIVE:the low degree of inflammation in obesity contributes to systemic metabolic dysfunction. Recent experimental studies proposed some effects of alteration in gut microbiota on inflammatory factors. This study aimed to assess the anti-inflammatory effects of a synbiotic supplement on inflammation markers in overweight and obese children and adolescents.METHODS:this randomized triple-masked controlled trial was conducted among 70 participants aged 6 to 18 years, with a body mass index (BMI) equal or higher than the 85th percentile. They were randomly assigned into two groups of equal number to receive synbiotic or placebo for eight weeks.RESULTS:fifty-six of 70 participants (80%) completed the study. Compared with the placebo group, the synbiotic group had significant decrease in mean values of tumor necrosis-α and interleukin-6, with significant increase in adiponectin; these changes were no longer significant after adjustment for BMI. There was no significant change in the mean values of high-sensitive C-reactive protein.CONCLUSION:the present findings suggest the positive influence of synbiotic supplementation on inflammation factors, which are dependent to its effect on weight reduction in overweight and obese children. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000200161 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000200161 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2013.07.003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.90 n.2 2014 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
_version_ |
1752122319578333184 |