Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness

Detalhes bibliográficos
Autor(a) principal: Nascimento,Renata Medeiros do
Data de Publicação: 2021
Outros Autores: Baptista,Paulo Neves, Lopes,Katiuscia Araújo de Miranda, Pimentel,Analíria Moraes, Cruz,Fábia da Silva Pereira, Ximenes,Ricardo Arraes de Alencar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal de Pediatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000500500
Resumo: Abstract Objective: To assess the protective effect of exclusive breastfeeding and the effectiveness of maternal vaccination in reducing pertussis-like illness. Method: This was a case-control study conducted in sentinel hospitals for pertussis in Recife between July 2016 and July 2018. Cases included children aged under six months with symptoms compatible with pertussis (pertussis-like illness). Controls included children aged under six months, living in the metropolitan region of Recife with no diagnosis of pertussis-like illness and matched by the same hospital and birth date. Results: Seventy-three cases and 194 controls were included. The diagnosis of pertussis-like illness was predominantly clinical (97,2%). Amongst the main symptoms, paroxysmal cough was observed in 95.89% of cases and vomiting in 53.4%. There were 29 hospitalized cases and no deaths. Out of the 73 cases, 47 were born to mothers vaccinated against pertussis during pregnancy, and the mothers of 144 of the 194 controls had been vaccinated. The protective effect of breastfeeding was of 74% (95% CI;38%, 89%). Children younger than six months, who were exclusively breastfed and with mothers vaccinated against pertussis during pregnancy were 5 times less likely to develop pertussis-like illness, corresponding to a protection of 79% (95% CI;31%, 94%). The effectiveness of maternal vaccination against pertussis-like illness in children under six months was low (27%) and not statistically significant (CI 95%; −34% a 60%). Conclusions: Exclusive breastfeeding protects children under six months from pertussis-like illness and may be enhanced when associated with maternal vaccination. These strategies should be encouraged because they also protect against pertussis-like illnesses.
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spelling Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illnessPertussisBreastfeedingDiphtheriatetanus and acellular pertussis vaccineImmunizationEffectivenessAbstract Objective: To assess the protective effect of exclusive breastfeeding and the effectiveness of maternal vaccination in reducing pertussis-like illness. Method: This was a case-control study conducted in sentinel hospitals for pertussis in Recife between July 2016 and July 2018. Cases included children aged under six months with symptoms compatible with pertussis (pertussis-like illness). Controls included children aged under six months, living in the metropolitan region of Recife with no diagnosis of pertussis-like illness and matched by the same hospital and birth date. Results: Seventy-three cases and 194 controls were included. The diagnosis of pertussis-like illness was predominantly clinical (97,2%). Amongst the main symptoms, paroxysmal cough was observed in 95.89% of cases and vomiting in 53.4%. There were 29 hospitalized cases and no deaths. Out of the 73 cases, 47 were born to mothers vaccinated against pertussis during pregnancy, and the mothers of 144 of the 194 controls had been vaccinated. The protective effect of breastfeeding was of 74% (95% CI;38%, 89%). Children younger than six months, who were exclusively breastfed and with mothers vaccinated against pertussis during pregnancy were 5 times less likely to develop pertussis-like illness, corresponding to a protection of 79% (95% CI;31%, 94%). The effectiveness of maternal vaccination against pertussis-like illness in children under six months was low (27%) and not statistically significant (CI 95%; −34% a 60%). Conclusions: Exclusive breastfeeding protects children under six months from pertussis-like illness and may be enhanced when associated with maternal vaccination. These strategies should be encouraged because they also protect against pertussis-like illnesses.Sociedade Brasileira de Pediatria2021-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000500500Jornal de Pediatria v.97 n.5 2021reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2020.10.018info:eu-repo/semantics/openAccessNascimento,Renata Medeiros doBaptista,Paulo NevesLopes,Katiuscia Araújo de MirandaPimentel,Analíria MoraesCruz,Fábia da Silva PereiraXimenes,Ricardo Arraes de Alencareng2021-10-08T00:00:00Zoai:scielo:S0021-75572021000500500Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2021-10-08T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false
dc.title.none.fl_str_mv Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness
title Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness
spellingShingle Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness
Nascimento,Renata Medeiros do
Pertussis
Breastfeeding
Diphtheria
tetanus and acellular pertussis vaccine
Immunization
Effectiveness
title_short Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness
title_full Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness
title_fullStr Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness
title_full_unstemmed Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness
title_sort Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness
author Nascimento,Renata Medeiros do
author_facet Nascimento,Renata Medeiros do
Baptista,Paulo Neves
Lopes,Katiuscia Araújo de Miranda
Pimentel,Analíria Moraes
Cruz,Fábia da Silva Pereira
Ximenes,Ricardo Arraes de Alencar
author_role author
author2 Baptista,Paulo Neves
Lopes,Katiuscia Araújo de Miranda
Pimentel,Analíria Moraes
Cruz,Fábia da Silva Pereira
Ximenes,Ricardo Arraes de Alencar
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento,Renata Medeiros do
Baptista,Paulo Neves
Lopes,Katiuscia Araújo de Miranda
Pimentel,Analíria Moraes
Cruz,Fábia da Silva Pereira
Ximenes,Ricardo Arraes de Alencar
dc.subject.por.fl_str_mv Pertussis
Breastfeeding
Diphtheria
tetanus and acellular pertussis vaccine
Immunization
Effectiveness
topic Pertussis
Breastfeeding
Diphtheria
tetanus and acellular pertussis vaccine
Immunization
Effectiveness
description Abstract Objective: To assess the protective effect of exclusive breastfeeding and the effectiveness of maternal vaccination in reducing pertussis-like illness. Method: This was a case-control study conducted in sentinel hospitals for pertussis in Recife between July 2016 and July 2018. Cases included children aged under six months with symptoms compatible with pertussis (pertussis-like illness). Controls included children aged under six months, living in the metropolitan region of Recife with no diagnosis of pertussis-like illness and matched by the same hospital and birth date. Results: Seventy-three cases and 194 controls were included. The diagnosis of pertussis-like illness was predominantly clinical (97,2%). Amongst the main symptoms, paroxysmal cough was observed in 95.89% of cases and vomiting in 53.4%. There were 29 hospitalized cases and no deaths. Out of the 73 cases, 47 were born to mothers vaccinated against pertussis during pregnancy, and the mothers of 144 of the 194 controls had been vaccinated. The protective effect of breastfeeding was of 74% (95% CI;38%, 89%). Children younger than six months, who were exclusively breastfed and with mothers vaccinated against pertussis during pregnancy were 5 times less likely to develop pertussis-like illness, corresponding to a protection of 79% (95% CI;31%, 94%). The effectiveness of maternal vaccination against pertussis-like illness in children under six months was low (27%) and not statistically significant (CI 95%; −34% a 60%). Conclusions: Exclusive breastfeeding protects children under six months from pertussis-like illness and may be enhanced when associated with maternal vaccination. These strategies should be encouraged because they also protect against pertussis-like illnesses.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000500500
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000500500
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jped.2020.10.018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Jornal de Pediatria v.97 n.5 2021
reponame:Jornal de Pediatria (Online)
instname:Sociedade Brasileira de Pediatria (SBP)
instacron:SBPE
instname_str Sociedade Brasileira de Pediatria (SBP)
instacron_str SBPE
institution SBPE
reponame_str Jornal de Pediatria (Online)
collection Jornal de Pediatria (Online)
repository.name.fl_str_mv Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)
repository.mail.fl_str_mv ||jped@jped.com.br
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