Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line

Detalhes bibliográficos
Autor(a) principal: Hernandes,C.
Data de Publicação: 2012
Outros Autores: Cardozo,G.P., França,S.C., Fachin,A.L., Marins,M., Lourenço,M.V
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista brasileira de plantas medicinais (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-05722012000100017
Resumo: Cancer is one of the leading causes of death in dogs, a fact that has boosted the investigation for new more specific antitumor drugs. This study evaluated the antitumor activity of jasmonates in the canine macrophage cell line DH82 (ATCC # CRL-10389) isolated from a case of malignant histiocytoma. The activities of methyl jasmonate and jasmonic acid were compared to that of doxorubicin by the MTT assay. Methyl jasmonate resulted in the highest inhibition of cell growth (82.2%), followed by doxorubicin (80.7%) and jasmonic acid (36.5%). More detailed studies regarding the action of jasmonates on animal health are necessary, but the present results indicate methyl jasmonate as an alternative to the development of drugs for the treatment of canine oncologies.
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spelling Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell linejasmonateshistiocytomadogsCancer is one of the leading causes of death in dogs, a fact that has boosted the investigation for new more specific antitumor drugs. This study evaluated the antitumor activity of jasmonates in the canine macrophage cell line DH82 (ATCC # CRL-10389) isolated from a case of malignant histiocytoma. The activities of methyl jasmonate and jasmonic acid were compared to that of doxorubicin by the MTT assay. Methyl jasmonate resulted in the highest inhibition of cell growth (82.2%), followed by doxorubicin (80.7%) and jasmonic acid (36.5%). More detailed studies regarding the action of jasmonates on animal health are necessary, but the present results indicate methyl jasmonate as an alternative to the development of drugs for the treatment of canine oncologies.Sociedade Brasileira de Plantas Medicinais2012-01-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-05722012000100017Revista Brasileira de Plantas Medicinais v.14 n.1 2012reponame:Revista brasileira de plantas medicinais (Online)instname:Universidade Estadual Paulista (UNESP)instacron:SBPM10.1590/S1516-05722012000100017info:eu-repo/semantics/openAccessHernandes,C.Cardozo,G.P.França,S.C.Fachin,A.L.Marins,M.Lourenço,M.Veng2013-10-09T00:00:00Zoai:scielo:S1516-05722012000100017Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=1516-0572&lng=en&nrm=isoPUBhttps://old.scielo.br/oai/scielo-oai.php||rbpm.sbpm@gmail.com1983-084X1516-0572opendoar:2013-10-09T00:00Revista brasileira de plantas medicinais (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line
title Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line
spellingShingle Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line
Hernandes,C.
jasmonates
histiocytoma
dogs
title_short Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line
title_full Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line
title_fullStr Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line
title_full_unstemmed Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line
title_sort Cytotoxic effect of jasmonate and methyl jasmonate on a canine macrophage tumor cell line
author Hernandes,C.
author_facet Hernandes,C.
Cardozo,G.P.
França,S.C.
Fachin,A.L.
Marins,M.
Lourenço,M.V
author_role author
author2 Cardozo,G.P.
França,S.C.
Fachin,A.L.
Marins,M.
Lourenço,M.V
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Hernandes,C.
Cardozo,G.P.
França,S.C.
Fachin,A.L.
Marins,M.
Lourenço,M.V
dc.subject.por.fl_str_mv jasmonates
histiocytoma
dogs
topic jasmonates
histiocytoma
dogs
description Cancer is one of the leading causes of death in dogs, a fact that has boosted the investigation for new more specific antitumor drugs. This study evaluated the antitumor activity of jasmonates in the canine macrophage cell line DH82 (ATCC # CRL-10389) isolated from a case of malignant histiocytoma. The activities of methyl jasmonate and jasmonic acid were compared to that of doxorubicin by the MTT assay. Methyl jasmonate resulted in the highest inhibition of cell growth (82.2%), followed by doxorubicin (80.7%) and jasmonic acid (36.5%). More detailed studies regarding the action of jasmonates on animal health are necessary, but the present results indicate methyl jasmonate as an alternative to the development of drugs for the treatment of canine oncologies.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-05722012000100017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-05722012000100017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-05722012000100017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Plantas Medicinais
publisher.none.fl_str_mv Sociedade Brasileira de Plantas Medicinais
dc.source.none.fl_str_mv Revista Brasileira de Plantas Medicinais v.14 n.1 2012
reponame:Revista brasileira de plantas medicinais (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:SBPM
instname_str Universidade Estadual Paulista (UNESP)
instacron_str SBPM
institution SBPM
reponame_str Revista brasileira de plantas medicinais (Online)
collection Revista brasileira de plantas medicinais (Online)
repository.name.fl_str_mv Revista brasileira de plantas medicinais (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||rbpm.sbpm@gmail.com
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