Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis

Detalhes bibliográficos
Autor(a) principal: Corrêa,Fernanda de Oliveira Bello
Data de Publicação: 2005
Outros Autores: Giro,Gabriela, Gonçalves,Daniela, Spolidorio,Luis Carlos, Orrico,Silvana Regina Perez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000300002
Resumo: The administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty young male rats were separated into eight groups according to the dosage and duration of treatment. Rats were treated for 20 or 40 days with a daily subcutaneous injection of 5, 20 or 50 mg/kg of body weight of diltiazem. The results confirmed that diltiazem did not induce gingival overgrowth in rats. For all animals, the evaluation did not show gingival alterations regardless of the dosages and periods of treatment. The histometric analysis showed no significant change in the area of epithelium and connective tissues, although after 40 days of treatment a decrease in the area of connective tissue was observed, without statistically significant difference from control groups. Within the limits of this study, we suggest that diltiazem did not induce gingival overgrowth.
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spelling Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysisDiltiazemAntihypertensive agentsGingival overgrowthThe administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty young male rats were separated into eight groups according to the dosage and duration of treatment. Rats were treated for 20 or 40 days with a daily subcutaneous injection of 5, 20 or 50 mg/kg of body weight of diltiazem. The results confirmed that diltiazem did not induce gingival overgrowth in rats. For all animals, the evaluation did not show gingival alterations regardless of the dosages and periods of treatment. The histometric analysis showed no significant change in the area of epithelium and connective tissues, although after 40 days of treatment a decrease in the area of connective tissue was observed, without statistically significant difference from control groups. Within the limits of this study, we suggest that diltiazem did not induce gingival overgrowth.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2005-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000300002Brazilian Oral Research v.19 n.3 2005reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242005000300002info:eu-repo/semantics/openAccessCorrêa,Fernanda de Oliveira BelloGiro,GabrielaGonçalves,DanielaSpolidorio,Luis CarlosOrrico,Silvana Regina Perezeng2005-11-21T00:00:00Zoai:scielo:S1806-83242005000300002Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2005-11-21T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis
title Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis
spellingShingle Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis
Corrêa,Fernanda de Oliveira Bello
Diltiazem
Antihypertensive agents
Gingival overgrowth
title_short Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis
title_full Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis
title_fullStr Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis
title_full_unstemmed Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis
title_sort Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis
author Corrêa,Fernanda de Oliveira Bello
author_facet Corrêa,Fernanda de Oliveira Bello
Giro,Gabriela
Gonçalves,Daniela
Spolidorio,Luis Carlos
Orrico,Silvana Regina Perez
author_role author
author2 Giro,Gabriela
Gonçalves,Daniela
Spolidorio,Luis Carlos
Orrico,Silvana Regina Perez
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Corrêa,Fernanda de Oliveira Bello
Giro,Gabriela
Gonçalves,Daniela
Spolidorio,Luis Carlos
Orrico,Silvana Regina Perez
dc.subject.por.fl_str_mv Diltiazem
Antihypertensive agents
Gingival overgrowth
topic Diltiazem
Antihypertensive agents
Gingival overgrowth
description The administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty young male rats were separated into eight groups according to the dosage and duration of treatment. Rats were treated for 20 or 40 days with a daily subcutaneous injection of 5, 20 or 50 mg/kg of body weight of diltiazem. The results confirmed that diltiazem did not induce gingival overgrowth in rats. For all animals, the evaluation did not show gingival alterations regardless of the dosages and periods of treatment. The histometric analysis showed no significant change in the area of epithelium and connective tissues, although after 40 days of treatment a decrease in the area of connective tissue was observed, without statistically significant difference from control groups. Within the limits of this study, we suggest that diltiazem did not induce gingival overgrowth.
publishDate 2005
dc.date.none.fl_str_mv 2005-09-01
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1806-83242005000300002
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.19 n.3 2005
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
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reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
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