Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000300002 |
Resumo: | The administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty young male rats were separated into eight groups according to the dosage and duration of treatment. Rats were treated for 20 or 40 days with a daily subcutaneous injection of 5, 20 or 50 mg/kg of body weight of diltiazem. The results confirmed that diltiazem did not induce gingival overgrowth in rats. For all animals, the evaluation did not show gingival alterations regardless of the dosages and periods of treatment. The histometric analysis showed no significant change in the area of epithelium and connective tissues, although after 40 days of treatment a decrease in the area of connective tissue was observed, without statistically significant difference from control groups. Within the limits of this study, we suggest that diltiazem did not induce gingival overgrowth. |
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Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysisDiltiazemAntihypertensive agentsGingival overgrowthThe administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty young male rats were separated into eight groups according to the dosage and duration of treatment. Rats were treated for 20 or 40 days with a daily subcutaneous injection of 5, 20 or 50 mg/kg of body weight of diltiazem. The results confirmed that diltiazem did not induce gingival overgrowth in rats. For all animals, the evaluation did not show gingival alterations regardless of the dosages and periods of treatment. The histometric analysis showed no significant change in the area of epithelium and connective tissues, although after 40 days of treatment a decrease in the area of connective tissue was observed, without statistically significant difference from control groups. Within the limits of this study, we suggest that diltiazem did not induce gingival overgrowth.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2005-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000300002Brazilian Oral Research v.19 n.3 2005reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242005000300002info:eu-repo/semantics/openAccessCorrêa,Fernanda de Oliveira BelloGiro,GabrielaGonçalves,DanielaSpolidorio,Luis CarlosOrrico,Silvana Regina Perezeng2005-11-21T00:00:00Zoai:scielo:S1806-83242005000300002Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2005-11-21T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis |
title |
Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis |
spellingShingle |
Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis Corrêa,Fernanda de Oliveira Bello Diltiazem Antihypertensive agents Gingival overgrowth |
title_short |
Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis |
title_full |
Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis |
title_fullStr |
Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis |
title_full_unstemmed |
Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis |
title_sort |
Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis |
author |
Corrêa,Fernanda de Oliveira Bello |
author_facet |
Corrêa,Fernanda de Oliveira Bello Giro,Gabriela Gonçalves,Daniela Spolidorio,Luis Carlos Orrico,Silvana Regina Perez |
author_role |
author |
author2 |
Giro,Gabriela Gonçalves,Daniela Spolidorio,Luis Carlos Orrico,Silvana Regina Perez |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Corrêa,Fernanda de Oliveira Bello Giro,Gabriela Gonçalves,Daniela Spolidorio,Luis Carlos Orrico,Silvana Regina Perez |
dc.subject.por.fl_str_mv |
Diltiazem Antihypertensive agents Gingival overgrowth |
topic |
Diltiazem Antihypertensive agents Gingival overgrowth |
description |
The administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty young male rats were separated into eight groups according to the dosage and duration of treatment. Rats were treated for 20 or 40 days with a daily subcutaneous injection of 5, 20 or 50 mg/kg of body weight of diltiazem. The results confirmed that diltiazem did not induce gingival overgrowth in rats. For all animals, the evaluation did not show gingival alterations regardless of the dosages and periods of treatment. The histometric analysis showed no significant change in the area of epithelium and connective tissues, although after 40 days of treatment a decrease in the area of connective tissue was observed, without statistically significant difference from control groups. Within the limits of this study, we suggest that diltiazem did not induce gingival overgrowth. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000300002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000300002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1806-83242005000300002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.19 n.3 2005 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318320392863744 |