BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242017000100207 |
Resumo: | Abstract The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry. BPIFA2, the major BPI-fold containing protein in adult salivary glands, was detected only in the laryngeal pharynx; the lack of staining in salivary glands suggested salivary expression is either very late in development or is only in adult tissues. Early expression of BPIFA1 was seen in the trachea and nasal cavity with salivary gland expression only seen in late morphodifferentiation stages. BPIFB1 was seen in early neural tissue and at later stages in submandibular and sublingual glands. BPIFA1 is significantly expressed in early fetal oral tissue but BPIFB1 has extremely limited expression and the major salivary BPIF protein (BPIFA2) is not produced in fetal development. Further studies, with more sensitive techniques, will confirm the expression pattern and enable a better understanding of embryonic BPIF protein function. |
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Brazilian Oral Research |
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BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glandsImmunity, InnateImmunohistochemistryHumansSalivary GlandsAbstract The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry. BPIFA2, the major BPI-fold containing protein in adult salivary glands, was detected only in the laryngeal pharynx; the lack of staining in salivary glands suggested salivary expression is either very late in development or is only in adult tissues. Early expression of BPIFA1 was seen in the trachea and nasal cavity with salivary gland expression only seen in late morphodifferentiation stages. BPIFB1 was seen in early neural tissue and at later stages in submandibular and sublingual glands. BPIFA1 is significantly expressed in early fetal oral tissue but BPIFB1 has extremely limited expression and the major salivary BPIF protein (BPIFA2) is not produced in fetal development. Further studies, with more sensitive techniques, will confirm the expression pattern and enable a better understanding of embryonic BPIF protein function.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242017000100207Brazilian Oral Research v.31 2017reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2017.vol31.0006info:eu-repo/semantics/openAccessALVES,Daniel Berretta MoreiraBINGLE,LynneBINGLE,Colin DavidLOURENÇO,Silvia VanessaSILVA,Andréia AparecidaPEREIRA,Débora LimaVARGAS,Pablo Agustineng2017-01-13T00:00:00Zoai:scielo:S1806-83242017000100207Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2017-01-13T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands |
title |
BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands |
spellingShingle |
BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands ALVES,Daniel Berretta Moreira Immunity, Innate Immunohistochemistry Humans Salivary Glands |
title_short |
BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands |
title_full |
BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands |
title_fullStr |
BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands |
title_full_unstemmed |
BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands |
title_sort |
BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands |
author |
ALVES,Daniel Berretta Moreira |
author_facet |
ALVES,Daniel Berretta Moreira BINGLE,Lynne BINGLE,Colin David LOURENÇO,Silvia Vanessa SILVA,Andréia Aparecida PEREIRA,Débora Lima VARGAS,Pablo Agustin |
author_role |
author |
author2 |
BINGLE,Lynne BINGLE,Colin David LOURENÇO,Silvia Vanessa SILVA,Andréia Aparecida PEREIRA,Débora Lima VARGAS,Pablo Agustin |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
ALVES,Daniel Berretta Moreira BINGLE,Lynne BINGLE,Colin David LOURENÇO,Silvia Vanessa SILVA,Andréia Aparecida PEREIRA,Débora Lima VARGAS,Pablo Agustin |
dc.subject.por.fl_str_mv |
Immunity, Innate Immunohistochemistry Humans Salivary Glands |
topic |
Immunity, Innate Immunohistochemistry Humans Salivary Glands |
description |
Abstract The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry. BPIFA2, the major BPI-fold containing protein in adult salivary glands, was detected only in the laryngeal pharynx; the lack of staining in salivary glands suggested salivary expression is either very late in development or is only in adult tissues. Early expression of BPIFA1 was seen in the trachea and nasal cavity with salivary gland expression only seen in late morphodifferentiation stages. BPIFB1 was seen in early neural tissue and at later stages in submandibular and sublingual glands. BPIFA1 is significantly expressed in early fetal oral tissue but BPIFB1 has extremely limited expression and the major salivary BPIF protein (BPIFA2) is not produced in fetal development. Further studies, with more sensitive techniques, will confirm the expression pattern and enable a better understanding of embryonic BPIF protein function. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242017000100207 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242017000100207 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107bor-2017.vol31.0006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.31 2017 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318325220507648 |