Effect of dentifrices with different pH and fluoride concentrations on fluoride levels in biofilm and nails: an RCT

• Autor(a) principal: Campos,Fernanda de Araújo Trigueiro
• Data de Publicação: 2022
• Outros Autores: Caldas,Aparecida Tharlla Leite de, Santos,Carlus Alberto Oliveira dos, Silva,Silmara Andrade, Vieira,Andre Parente de Sá Barreto, Viana Filho,José Maria Chagas, Buzalaf,Marília Afonso Rabelo, Sampaio,Fábio Correia, Cardoso,Cristiane de Almeida Baldini
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Oral Research
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242022000100236
• topic: Dentifrices; Fluorides; Nails; Biofilms; Dental Caries; Randomized Controlled Trials as Topic

Abstract: Purpose: to evaluate the effect of dentifrice pH and fluoride concentration ([F]) on fluoride uptake on the biofilm and nails of children from a non-fluoridated area. Methods: two hundred and twenty-eight two- to four-year-old children were randomly allocated into 3 groups according to the type of dentifrice: G1: 1100 μg F/g, pH 4.5 (n = 76); G2: 750 μg F/g, pH 4.5 (n = 74); and G3: 1100 μg F/g, pH 7.0 (n = 78). Nails were collected at 4, 8, and 12 months after starting dentifrice use and biofilm was collected 5 and 60 minutes after toothbrushing. The concentrations of F in nails and biofilm were analyzed by HMDS facilitated diffusion. Data were analyzed by Kruskal-Wallis/Mann-Whitney's test and the comparison between biofilm collection times was done using Wilcoxon test (p £ 0.05). Results: a significant reduction of [F] in biofilm was observed 60 minutes after toothbrushing, regardless of the dentifrice used. However, 5 minutes after toothbrushing, G1 had a significantly higher [F] compared to G2 and G3, and 60 minutes after toothbrushing, [F] was significantly higher for G1 and G2 compared to G3. G1 and G3 had significantly higher [F] in the nails compared to G2. Conclusion: a lower dentifrice concentration is a relevant factor for the reduction of excessive fluoride intake. The use of a low-F acidified dentifrice combines the reduction of fluoride uptake with caries prevention by leading to greater incorporation of F into the biofilm over time.