Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats

Detalhes bibliográficos
Autor(a) principal: CIRANO,Fabiano Ribeiro
Data de Publicação: 2016
Outros Autores: CASARIN,Renato Correa Viana, RIBEIRO,Fernanda Vieira, CASATI,Marcio Zaffalon, PIMENTEL,Suzana Peres, TAIETE,Tiago, BERNARDI,Maria Martha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242016000100318
Resumo: Abstract The objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/Kg of resveratrol (RESV group, n = 12). The therapies were administered systemically for 30 days, for 19 days before periodontitis induction and then for another 11 days. Then, the presence and concentrations of Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans in the cotton ligatures collected from the first molars were evaluated using real-time PCR. Inter-group comparisons of the microbiological outcomes revealed that no differences were detected for P. gingivalis, T. forsythia and A. actinomycetemcomitans levels (p > 0.05). Continuous use of resveratrol did not promote additional benefits in microbiological outcomes during experimental periodontitis in rats.
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spelling Effect of Resveratrol on periodontal pathogens during experimental periodontitis in ratsresveratrolperiodontitisalveolar bone lossanti-inflammatory agentsanti-bacterial agentsAbstract The objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/Kg of resveratrol (RESV group, n = 12). The therapies were administered systemically for 30 days, for 19 days before periodontitis induction and then for another 11 days. Then, the presence and concentrations of Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans in the cotton ligatures collected from the first molars were evaluated using real-time PCR. Inter-group comparisons of the microbiological outcomes revealed that no differences were detected for P. gingivalis, T. forsythia and A. actinomycetemcomitans levels (p > 0.05). Continuous use of resveratrol did not promote additional benefits in microbiological outcomes during experimental periodontitis in rats.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242016000100318Brazilian Oral Research v.30 n.1 2016reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2016.vol30.0128info:eu-repo/semantics/openAccessCIRANO,Fabiano RibeiroCASARIN,Renato Correa VianaRIBEIRO,Fernanda VieiraCASATI,Marcio ZaffalonPIMENTEL,Suzana PeresTAIETE,TiagoBERNARDI,Maria Marthaeng2016-11-23T00:00:00Zoai:scielo:S1806-83242016000100318Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2016-11-23T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats
title Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats
spellingShingle Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats
CIRANO,Fabiano Ribeiro
resveratrol
periodontitis
alveolar bone loss
anti-inflammatory agents
anti-bacterial agents
title_short Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats
title_full Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats
title_fullStr Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats
title_full_unstemmed Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats
title_sort Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats
author CIRANO,Fabiano Ribeiro
author_facet CIRANO,Fabiano Ribeiro
CASARIN,Renato Correa Viana
RIBEIRO,Fernanda Vieira
CASATI,Marcio Zaffalon
PIMENTEL,Suzana Peres
TAIETE,Tiago
BERNARDI,Maria Martha
author_role author
author2 CASARIN,Renato Correa Viana
RIBEIRO,Fernanda Vieira
CASATI,Marcio Zaffalon
PIMENTEL,Suzana Peres
TAIETE,Tiago
BERNARDI,Maria Martha
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv CIRANO,Fabiano Ribeiro
CASARIN,Renato Correa Viana
RIBEIRO,Fernanda Vieira
CASATI,Marcio Zaffalon
PIMENTEL,Suzana Peres
TAIETE,Tiago
BERNARDI,Maria Martha
dc.subject.por.fl_str_mv resveratrol
periodontitis
alveolar bone loss
anti-inflammatory agents
anti-bacterial agents
topic resveratrol
periodontitis
alveolar bone loss
anti-inflammatory agents
anti-bacterial agents
description Abstract The objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/Kg of resveratrol (RESV group, n = 12). The therapies were administered systemically for 30 days, for 19 days before periodontitis induction and then for another 11 days. Then, the presence and concentrations of Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans in the cotton ligatures collected from the first molars were evaluated using real-time PCR. Inter-group comparisons of the microbiological outcomes revealed that no differences were detected for P. gingivalis, T. forsythia and A. actinomycetemcomitans levels (p > 0.05). Continuous use of resveratrol did not promote additional benefits in microbiological outcomes during experimental periodontitis in rats.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242016000100318
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242016000100318
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1807-3107bor-2016.vol30.0128
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.30 n.1 2016
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
instname_str Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron_str SBPQO
institution SBPQO
reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
repository.mail.fl_str_mv pob@edu.usp.br||bor@sbpqo.org.br
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