Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint

Detalhes bibliográficos
Autor(a) principal: Goulart,Alan Cruvinel
Data de Publicação: 2005
Outros Autores: Correia,Francisco Antônio dos Santos, Sousa,Suzana Cantanhede Orsini Machado de, Luz,João Gualberto de Cerqueira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000200005
Resumo: The aim of this study was to evaluate the effects of the injection of two phlogistic agents, carrageenan and formalin, in the rat TMJ, and the inflammatory process induced by these substances. In this study, a total of 45 adult rats were distributed in two experimental groups and a control group. The animals were sacrificed after three hours, 24 hours, three days, seven days, and 15 days after a single injection of each substance. Histological data initially demonstrated an inflammatory process represented by acute infiltration, which later became mixed, and finally chronic in both experimental groups. Hyperplasia of the synovial membrane was observed after three days, being intense at seven days, and present after 15 days only in the formalin group. Local saline injection in the control group caused no inflammatory reaction. It was concluded that a single local injection of carrageenan or formalin was enough to induce inflammatory reaction in the TMJ and periarticular soft tissues, and that the resulting processes were similar, but more persistent in the formalin group.
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spelling Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular jointTemporomandibular jointInflammationCarrageenan, adverse effectsFormalin/adverse effectsThe aim of this study was to evaluate the effects of the injection of two phlogistic agents, carrageenan and formalin, in the rat TMJ, and the inflammatory process induced by these substances. In this study, a total of 45 adult rats were distributed in two experimental groups and a control group. The animals were sacrificed after three hours, 24 hours, three days, seven days, and 15 days after a single injection of each substance. Histological data initially demonstrated an inflammatory process represented by acute infiltration, which later became mixed, and finally chronic in both experimental groups. Hyperplasia of the synovial membrane was observed after three days, being intense at seven days, and present after 15 days only in the formalin group. Local saline injection in the control group caused no inflammatory reaction. It was concluded that a single local injection of carrageenan or formalin was enough to induce inflammatory reaction in the TMJ and periarticular soft tissues, and that the resulting processes were similar, but more persistent in the formalin group.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000200005Brazilian Oral Research v.19 n.2 2005reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242005000200005info:eu-repo/semantics/openAccessGoulart,Alan CruvinelCorreia,Francisco Antônio dos SantosSousa,Suzana Cantanhede Orsini Machado deLuz,João Gualberto de Cerqueiraeng2005-09-13T00:00:00Zoai:scielo:S1806-83242005000200005Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2005-09-13T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint
title Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint
spellingShingle Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint
Goulart,Alan Cruvinel
Temporomandibular joint
Inflammation
Carrageenan, adverse effects
Formalin/adverse effects
title_short Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint
title_full Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint
title_fullStr Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint
title_full_unstemmed Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint
title_sort Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint
author Goulart,Alan Cruvinel
author_facet Goulart,Alan Cruvinel
Correia,Francisco Antônio dos Santos
Sousa,Suzana Cantanhede Orsini Machado de
Luz,João Gualberto de Cerqueira
author_role author
author2 Correia,Francisco Antônio dos Santos
Sousa,Suzana Cantanhede Orsini Machado de
Luz,João Gualberto de Cerqueira
author2_role author
author
author
dc.contributor.author.fl_str_mv Goulart,Alan Cruvinel
Correia,Francisco Antônio dos Santos
Sousa,Suzana Cantanhede Orsini Machado de
Luz,João Gualberto de Cerqueira
dc.subject.por.fl_str_mv Temporomandibular joint
Inflammation
Carrageenan, adverse effects
Formalin/adverse effects
topic Temporomandibular joint
Inflammation
Carrageenan, adverse effects
Formalin/adverse effects
description The aim of this study was to evaluate the effects of the injection of two phlogistic agents, carrageenan and formalin, in the rat TMJ, and the inflammatory process induced by these substances. In this study, a total of 45 adult rats were distributed in two experimental groups and a control group. The animals were sacrificed after three hours, 24 hours, three days, seven days, and 15 days after a single injection of each substance. Histological data initially demonstrated an inflammatory process represented by acute infiltration, which later became mixed, and finally chronic in both experimental groups. Hyperplasia of the synovial membrane was observed after three days, being intense at seven days, and present after 15 days only in the formalin group. Local saline injection in the control group caused no inflammatory reaction. It was concluded that a single local injection of carrageenan or formalin was enough to induce inflammatory reaction in the TMJ and periarticular soft tissues, and that the resulting processes were similar, but more persistent in the formalin group.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000200005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242005000200005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1806-83242005000200005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.19 n.2 2005
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
instname_str Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron_str SBPQO
institution SBPQO
reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
repository.mail.fl_str_mv pob@edu.usp.br||bor@sbpqo.org.br
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