Association of taste receptor gene polymorphisms with dental caries
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100243 |
Resumo: | Abstract This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescents). Parents/caregivers answered a self-administered questionnaire about their children’s systemic health, characteristics, oral hygiene habits, and diet. Clinical examination was performed to evaluate dental caries and nutritional status. Saliva samples were collected for DNA extraction. The genotyping of rs17492553 ( TAS1R1 ), rs3935570, and rs4920566 ( TAS1R2 ) polymorphisms was performed using real-time PCR with Taqman Genotyping Master Mix and SNP assay. Both univariate and multivariate Poisson regression analyses with robust variance were used for the data analysis. In preschool children, consumption of sweets between meals increased the prevalence of dental caries by 85% (PR c = 1.85; 95%CI 1.39–2.46; p < 0.001), whereas in pre-adolescents, this prevalence increased by 34% (PR a = 1.34; 95%CI 1.11–1.62; p = 0.002), regardless of genetic polymorphisms . Moreover, individuals carrying at least one allele C in rs17492553 presented 23% more prevalence of dental caries (PR a = 1.23; 95%CI 1.02–1.49 p = 0.030). Nutritional status was not associated with dental caries, neither with genetic polymorphisms . Consumption of sweets between meals increased the prevalence of dental caries. In pre-adolescents, rs17492553 genetic polymorphism in TAS1R1 was associated with dental caries. |
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Association of taste receptor gene polymorphisms with dental cariesPolymorphism, GeneticChildGeneticsDental CariesDietAbstract This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescents). Parents/caregivers answered a self-administered questionnaire about their children’s systemic health, characteristics, oral hygiene habits, and diet. Clinical examination was performed to evaluate dental caries and nutritional status. Saliva samples were collected for DNA extraction. The genotyping of rs17492553 ( TAS1R1 ), rs3935570, and rs4920566 ( TAS1R2 ) polymorphisms was performed using real-time PCR with Taqman Genotyping Master Mix and SNP assay. Both univariate and multivariate Poisson regression analyses with robust variance were used for the data analysis. In preschool children, consumption of sweets between meals increased the prevalence of dental caries by 85% (PR c = 1.85; 95%CI 1.39–2.46; p < 0.001), whereas in pre-adolescents, this prevalence increased by 34% (PR a = 1.34; 95%CI 1.11–1.62; p = 0.002), regardless of genetic polymorphisms . Moreover, individuals carrying at least one allele C in rs17492553 presented 23% more prevalence of dental caries (PR a = 1.23; 95%CI 1.02–1.49 p = 0.030). Nutritional status was not associated with dental caries, neither with genetic polymorphisms . Consumption of sweets between meals increased the prevalence of dental caries. In pre-adolescents, rs17492553 genetic polymorphism in TAS1R1 was associated with dental caries.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100243Brazilian Oral Research v.34 2020reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2020.vol34.0055info:eu-repo/semantics/openAccessARID,JulianaANTUNES,Lívia Azeredo AlvesKOCH,Luiza Foltran de AzevedoEVANGELISTA,Silvane SilvaVASCONCELOS,Katia Regina FelizardoBRANCHER,João ArmandoGABARDO,Marilisa Carneiro LeãoMILANI,Ana JuliaDUTRA,André Luiz TannusANTUNES,Leonardo SantosVIEIRA,Alexandre RezendeFELTRIN-SOUZA,JulianaKÜCHLER,Erika Calvanoeng2020-06-16T00:00:00Zoai:scielo:S1806-83242020000100243Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2020-06-16T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Association of taste receptor gene polymorphisms with dental caries |
title |
Association of taste receptor gene polymorphisms with dental caries |
spellingShingle |
Association of taste receptor gene polymorphisms with dental caries ARID,Juliana Polymorphism, Genetic Child Genetics Dental Caries Diet |
title_short |
Association of taste receptor gene polymorphisms with dental caries |
title_full |
Association of taste receptor gene polymorphisms with dental caries |
title_fullStr |
Association of taste receptor gene polymorphisms with dental caries |
title_full_unstemmed |
Association of taste receptor gene polymorphisms with dental caries |
title_sort |
Association of taste receptor gene polymorphisms with dental caries |
author |
ARID,Juliana |
author_facet |
ARID,Juliana ANTUNES,Lívia Azeredo Alves KOCH,Luiza Foltran de Azevedo EVANGELISTA,Silvane Silva VASCONCELOS,Katia Regina Felizardo BRANCHER,João Armando GABARDO,Marilisa Carneiro Leão MILANI,Ana Julia DUTRA,André Luiz Tannus ANTUNES,Leonardo Santos VIEIRA,Alexandre Rezende FELTRIN-SOUZA,Juliana KÜCHLER,Erika Calvano |
author_role |
author |
author2 |
ANTUNES,Lívia Azeredo Alves KOCH,Luiza Foltran de Azevedo EVANGELISTA,Silvane Silva VASCONCELOS,Katia Regina Felizardo BRANCHER,João Armando GABARDO,Marilisa Carneiro Leão MILANI,Ana Julia DUTRA,André Luiz Tannus ANTUNES,Leonardo Santos VIEIRA,Alexandre Rezende FELTRIN-SOUZA,Juliana KÜCHLER,Erika Calvano |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
ARID,Juliana ANTUNES,Lívia Azeredo Alves KOCH,Luiza Foltran de Azevedo EVANGELISTA,Silvane Silva VASCONCELOS,Katia Regina Felizardo BRANCHER,João Armando GABARDO,Marilisa Carneiro Leão MILANI,Ana Julia DUTRA,André Luiz Tannus ANTUNES,Leonardo Santos VIEIRA,Alexandre Rezende FELTRIN-SOUZA,Juliana KÜCHLER,Erika Calvano |
dc.subject.por.fl_str_mv |
Polymorphism, Genetic Child Genetics Dental Caries Diet |
topic |
Polymorphism, Genetic Child Genetics Dental Caries Diet |
description |
Abstract This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescents). Parents/caregivers answered a self-administered questionnaire about their children’s systemic health, characteristics, oral hygiene habits, and diet. Clinical examination was performed to evaluate dental caries and nutritional status. Saliva samples were collected for DNA extraction. The genotyping of rs17492553 ( TAS1R1 ), rs3935570, and rs4920566 ( TAS1R2 ) polymorphisms was performed using real-time PCR with Taqman Genotyping Master Mix and SNP assay. Both univariate and multivariate Poisson regression analyses with robust variance were used for the data analysis. In preschool children, consumption of sweets between meals increased the prevalence of dental caries by 85% (PR c = 1.85; 95%CI 1.39–2.46; p < 0.001), whereas in pre-adolescents, this prevalence increased by 34% (PR a = 1.34; 95%CI 1.11–1.62; p = 0.002), regardless of genetic polymorphisms . Moreover, individuals carrying at least one allele C in rs17492553 presented 23% more prevalence of dental caries (PR a = 1.23; 95%CI 1.02–1.49 p = 0.030). Nutritional status was not associated with dental caries, neither with genetic polymorphisms . Consumption of sweets between meals increased the prevalence of dental caries. In pre-adolescents, rs17492553 genetic polymorphism in TAS1R1 was associated with dental caries. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100243 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100243 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107bor-2020.vol34.0055 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.34 2020 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
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1750318327089070080 |