Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100266 |
Resumo: | Abstract Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) act in the proteolysis of basement membrane and extracellular matrix structures, facilitating tumor invasion. The purpose of this study was to evaluate the relationship between these proteins and clinicopathological parameters in squamous cell carcinoma of the oral tongue (SCCOT). Sixty cases of SCCOT were submitted to immunohistochemistry and analyzed semiquantitatively at the invasion front and in the tumor core. The results were associated with lymph node metastasis, clinical stage, locoregional recurrence, clinical outcome and histological grade of malignancy. A higher expression of uPA was observed in cases of tumors of high-grade versus low-grade malignancy (p = 0.010). Moreover, the cases with the worst pattern of invasion presented an overexpression of uPA (p = 0.011). The presence of locoregional recurrence was associated with uPAR (p = 0.039), and the expression of both biomarkers was much higher at the invasion front than in the tumor core (p < 0.001). The results suggest uPA and uPAR are involved in the progression and aggressiveness of SCCOT, mainly at the tumor-host interface. |
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Brazilian Oral Research |
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Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongueCarcinoma, Squamous CellImmunohistochemistryPlasminogen ActivatorAbstract Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) act in the proteolysis of basement membrane and extracellular matrix structures, facilitating tumor invasion. The purpose of this study was to evaluate the relationship between these proteins and clinicopathological parameters in squamous cell carcinoma of the oral tongue (SCCOT). Sixty cases of SCCOT were submitted to immunohistochemistry and analyzed semiquantitatively at the invasion front and in the tumor core. The results were associated with lymph node metastasis, clinical stage, locoregional recurrence, clinical outcome and histological grade of malignancy. A higher expression of uPA was observed in cases of tumors of high-grade versus low-grade malignancy (p = 0.010). Moreover, the cases with the worst pattern of invasion presented an overexpression of uPA (p = 0.011). The presence of locoregional recurrence was associated with uPAR (p = 0.039), and the expression of both biomarkers was much higher at the invasion front than in the tumor core (p < 0.001). The results suggest uPA and uPAR are involved in the progression and aggressiveness of SCCOT, mainly at the tumor-host interface.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100266Brazilian Oral Research v.32 2018reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2018.vol32.0093info:eu-repo/semantics/openAccessSERPA,Marianna SampaioMAFRA,Rodrigo PorpinoQUEIROZ,Salomão Israel Monteiro LourençoSILVA,Leorik Pereira daSOUZA,Lélia Batista dePINTO,Leão Pereiraeng2018-09-06T00:00:00Zoai:scielo:S1806-83242018000100266Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2018-09-06T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
title |
Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
spellingShingle |
Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue SERPA,Marianna Sampaio Carcinoma, Squamous Cell Immunohistochemistry Plasminogen Activator |
title_short |
Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
title_full |
Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
title_fullStr |
Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
title_full_unstemmed |
Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
title_sort |
Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
author |
SERPA,Marianna Sampaio |
author_facet |
SERPA,Marianna Sampaio MAFRA,Rodrigo Porpino QUEIROZ,Salomão Israel Monteiro Lourenço SILVA,Leorik Pereira da SOUZA,Lélia Batista de PINTO,Leão Pereira |
author_role |
author |
author2 |
MAFRA,Rodrigo Porpino QUEIROZ,Salomão Israel Monteiro Lourenço SILVA,Leorik Pereira da SOUZA,Lélia Batista de PINTO,Leão Pereira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
SERPA,Marianna Sampaio MAFRA,Rodrigo Porpino QUEIROZ,Salomão Israel Monteiro Lourenço SILVA,Leorik Pereira da SOUZA,Lélia Batista de PINTO,Leão Pereira |
dc.subject.por.fl_str_mv |
Carcinoma, Squamous Cell Immunohistochemistry Plasminogen Activator |
topic |
Carcinoma, Squamous Cell Immunohistochemistry Plasminogen Activator |
description |
Abstract Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) act in the proteolysis of basement membrane and extracellular matrix structures, facilitating tumor invasion. The purpose of this study was to evaluate the relationship between these proteins and clinicopathological parameters in squamous cell carcinoma of the oral tongue (SCCOT). Sixty cases of SCCOT were submitted to immunohistochemistry and analyzed semiquantitatively at the invasion front and in the tumor core. The results were associated with lymph node metastasis, clinical stage, locoregional recurrence, clinical outcome and histological grade of malignancy. A higher expression of uPA was observed in cases of tumors of high-grade versus low-grade malignancy (p = 0.010). Moreover, the cases with the worst pattern of invasion presented an overexpression of uPA (p = 0.011). The presence of locoregional recurrence was associated with uPAR (p = 0.039), and the expression of both biomarkers was much higher at the invasion front than in the tumor core (p < 0.001). The results suggest uPA and uPAR are involved in the progression and aggressiveness of SCCOT, mainly at the tumor-host interface. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100266 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100266 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107bor-2018.vol32.0093 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.32 2018 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318326088728576 |