Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242013000300252 |
Resumo: | Precise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dual-energy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy. |
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Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapyBone DensityAlendronateBone RemodelingPrecise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dual-energy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242013000300252Brazilian Oral Research v.27 n.3 2013reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242013000300005info:eu-repo/semantics/openAccessLucisano,Marília PacíficoNelson-Filho,PauloMorse,LeslieBattaglino,RicardoWatanabe,Plauto Christopher Aranhada Silva,Raquel Assed Bezerrada Silva,Lea Assed Bezerraeng2013-05-28T00:00:00Zoai:scielo:S1806-83242013000300252Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2013-05-28T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy |
title |
Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy |
spellingShingle |
Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy Lucisano,Marília Pacífico Bone Density Alendronate Bone Remodeling |
title_short |
Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy |
title_full |
Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy |
title_fullStr |
Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy |
title_full_unstemmed |
Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy |
title_sort |
Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy |
author |
Lucisano,Marília Pacífico |
author_facet |
Lucisano,Marília Pacífico Nelson-Filho,Paulo Morse,Leslie Battaglino,Ricardo Watanabe,Plauto Christopher Aranha da Silva,Raquel Assed Bezerra da Silva,Lea Assed Bezerra |
author_role |
author |
author2 |
Nelson-Filho,Paulo Morse,Leslie Battaglino,Ricardo Watanabe,Plauto Christopher Aranha da Silva,Raquel Assed Bezerra da Silva,Lea Assed Bezerra |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lucisano,Marília Pacífico Nelson-Filho,Paulo Morse,Leslie Battaglino,Ricardo Watanabe,Plauto Christopher Aranha da Silva,Raquel Assed Bezerra da Silva,Lea Assed Bezerra |
dc.subject.por.fl_str_mv |
Bone Density Alendronate Bone Remodeling |
topic |
Bone Density Alendronate Bone Remodeling |
description |
Precise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dual-energy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242013000300252 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242013000300252 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1806-83242013000300005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.27 n.3 2013 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318323377111040 |