Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200008 |
Resumo: | Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA. |
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Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric studyHypertensionBone remodelingBone densityRats/Inbred SHRClinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200008Brazilian Oral Research v.24 n.2 2010reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242010000200008info:eu-repo/semantics/openAccessBastos,Marta FerreiraBrilhante,Felipe VilhenaBezerra,Joyce PinhoSilva,Carlos AlbertoDuarte,Poliana Mendeseng2010-07-22T00:00:00Zoai:scielo:S1806-83242010000200008Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2010-07-22T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study |
title |
Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study |
spellingShingle |
Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study Bastos,Marta Ferreira Hypertension Bone remodeling Bone density Rats/Inbred SHR |
title_short |
Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study |
title_full |
Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study |
title_fullStr |
Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study |
title_full_unstemmed |
Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study |
title_sort |
Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study |
author |
Bastos,Marta Ferreira |
author_facet |
Bastos,Marta Ferreira Brilhante,Felipe Vilhena Bezerra,Joyce Pinho Silva,Carlos Alberto Duarte,Poliana Mendes |
author_role |
author |
author2 |
Brilhante,Felipe Vilhena Bezerra,Joyce Pinho Silva,Carlos Alberto Duarte,Poliana Mendes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Bastos,Marta Ferreira Brilhante,Felipe Vilhena Bezerra,Joyce Pinho Silva,Carlos Alberto Duarte,Poliana Mendes |
dc.subject.por.fl_str_mv |
Hypertension Bone remodeling Bone density Rats/Inbred SHR |
topic |
Hypertension Bone remodeling Bone density Rats/Inbred SHR |
description |
Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1806-83242010000200008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.24 n.2 2010 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318322028642304 |