Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

Detalhes bibliográficos
Autor(a) principal: Bastos,Marta Ferreira
Data de Publicação: 2010
Outros Autores: Brilhante,Felipe Vilhena, Bezerra,Joyce Pinho, Silva,Carlos Alberto, Duarte,Poliana Mendes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200008
Resumo: Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.
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spelling Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric studyHypertensionBone remodelingBone densityRats/Inbred SHRClinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200008Brazilian Oral Research v.24 n.2 2010reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242010000200008info:eu-repo/semantics/openAccessBastos,Marta FerreiraBrilhante,Felipe VilhenaBezerra,Joyce PinhoSilva,Carlos AlbertoDuarte,Poliana Mendeseng2010-07-22T00:00:00Zoai:scielo:S1806-83242010000200008Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2010-07-22T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
title Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
spellingShingle Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
Bastos,Marta Ferreira
Hypertension
Bone remodeling
Bone density
Rats/Inbred SHR
title_short Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
title_full Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
title_fullStr Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
title_full_unstemmed Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
title_sort Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
author Bastos,Marta Ferreira
author_facet Bastos,Marta Ferreira
Brilhante,Felipe Vilhena
Bezerra,Joyce Pinho
Silva,Carlos Alberto
Duarte,Poliana Mendes
author_role author
author2 Brilhante,Felipe Vilhena
Bezerra,Joyce Pinho
Silva,Carlos Alberto
Duarte,Poliana Mendes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bastos,Marta Ferreira
Brilhante,Felipe Vilhena
Bezerra,Joyce Pinho
Silva,Carlos Alberto
Duarte,Poliana Mendes
dc.subject.por.fl_str_mv Hypertension
Bone remodeling
Bone density
Rats/Inbred SHR
topic Hypertension
Bone remodeling
Bone density
Rats/Inbred SHR
description Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.
publishDate 2010
dc.date.none.fl_str_mv 2010-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1806-83242010000200008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.24 n.2 2010
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
instname_str Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
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institution SBPQO
reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
repository.mail.fl_str_mv pob@edu.usp.br||bor@sbpqo.org.br
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