Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer

Detalhes bibliográficos
Autor(a) principal: Suesada,Milena Mako
Data de Publicação: 2018
Outros Autores: Carvalho,Heloisa de Andrade, Albuquerque,André Luis Pereira de, Salge,João Marcos, Stuart,Silvia Radwanski, Takagaki,Teresa Yae
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Pneumologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600469
Resumo: ABSTRACT Objective: To evaluate the impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer. Methods: Breast cancer patients in whom thoracic radiotherapy was indicated after surgical treatment and chemotherapy were submitted to HRCT, respiratory evaluation, and exercise capacity evaluation before radiotherapy and at three months after treatment completion. Respiratory muscle strength testing, measurement of chest wall mobility, and complete pulmonary function testing were performed for respiratory evaluation; cardiopulmonary exercise testing was performed to evaluate exercise capacity. The total radiotherapy dose was 50.4 Gy (1.8 Gy/fraction) to the breast or chest wall, including supraclavicular lymph nodes (SCLN) or not. Dose-volume histograms were calculated for each patient with special attention to the ipsilateral lung volume receiving 25 Gy (V25), in absolute and relative values, and mean lung dose. Results: The study comprised 37 patients. After radiotherapy, significant decreases were observed in respiratory muscle strength, chest wall mobility, exercise capacity, and pulmonary function test results (p < 0.05). DLCO was unchanged. HRCT showed changes related to radiotherapy in 87% of the patients, which was more evident in the patients submitted to SCLN irradiation. V25% significantly correlated with radiation pneumonitis. Conclusions: In our sample of patients with breast cancer, thoracic radiotherapy seemed to have caused significant losses in respiratory and exercise capacity, probably due to chest wall restriction; SCLN irradiation represented an additional risk factor for the development of radiation pneumonitis.
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spelling Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancerBreast neoplasmsRadiotherapyRadiation pneumonitisRespiratory function testsExercise testABSTRACT Objective: To evaluate the impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer. Methods: Breast cancer patients in whom thoracic radiotherapy was indicated after surgical treatment and chemotherapy were submitted to HRCT, respiratory evaluation, and exercise capacity evaluation before radiotherapy and at three months after treatment completion. Respiratory muscle strength testing, measurement of chest wall mobility, and complete pulmonary function testing were performed for respiratory evaluation; cardiopulmonary exercise testing was performed to evaluate exercise capacity. The total radiotherapy dose was 50.4 Gy (1.8 Gy/fraction) to the breast or chest wall, including supraclavicular lymph nodes (SCLN) or not. Dose-volume histograms were calculated for each patient with special attention to the ipsilateral lung volume receiving 25 Gy (V25), in absolute and relative values, and mean lung dose. Results: The study comprised 37 patients. After radiotherapy, significant decreases were observed in respiratory muscle strength, chest wall mobility, exercise capacity, and pulmonary function test results (p < 0.05). DLCO was unchanged. HRCT showed changes related to radiotherapy in 87% of the patients, which was more evident in the patients submitted to SCLN irradiation. V25% significantly correlated with radiation pneumonitis. Conclusions: In our sample of patients with breast cancer, thoracic radiotherapy seemed to have caused significant losses in respiratory and exercise capacity, probably due to chest wall restriction; SCLN irradiation represented an additional risk factor for the development of radiation pneumonitis.Sociedade Brasileira de Pneumologia e Tisiologia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600469Jornal Brasileiro de Pneumologia v.44 n.6 2018reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/s1806-37562017000000120info:eu-repo/semantics/openAccessSuesada,Milena MakoCarvalho,Heloisa de AndradeAlbuquerque,André Luis Pereira deSalge,João MarcosStuart,Silvia RadwanskiTakagaki,Teresa Yaeeng2019-01-29T00:00:00Zoai:scielo:S1806-37132018000600469Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2019-01-29T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false
dc.title.none.fl_str_mv Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer
title Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer
spellingShingle Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer
Suesada,Milena Mako
Breast neoplasms
Radiotherapy
Radiation pneumonitis
Respiratory function tests
Exercise test
title_short Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer
title_full Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer
title_fullStr Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer
title_full_unstemmed Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer
title_sort Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer
author Suesada,Milena Mako
author_facet Suesada,Milena Mako
Carvalho,Heloisa de Andrade
Albuquerque,André Luis Pereira de
Salge,João Marcos
Stuart,Silvia Radwanski
Takagaki,Teresa Yae
author_role author
author2 Carvalho,Heloisa de Andrade
Albuquerque,André Luis Pereira de
Salge,João Marcos
Stuart,Silvia Radwanski
Takagaki,Teresa Yae
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Suesada,Milena Mako
Carvalho,Heloisa de Andrade
Albuquerque,André Luis Pereira de
Salge,João Marcos
Stuart,Silvia Radwanski
Takagaki,Teresa Yae
dc.subject.por.fl_str_mv Breast neoplasms
Radiotherapy
Radiation pneumonitis
Respiratory function tests
Exercise test
topic Breast neoplasms
Radiotherapy
Radiation pneumonitis
Respiratory function tests
Exercise test
description ABSTRACT Objective: To evaluate the impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer. Methods: Breast cancer patients in whom thoracic radiotherapy was indicated after surgical treatment and chemotherapy were submitted to HRCT, respiratory evaluation, and exercise capacity evaluation before radiotherapy and at three months after treatment completion. Respiratory muscle strength testing, measurement of chest wall mobility, and complete pulmonary function testing were performed for respiratory evaluation; cardiopulmonary exercise testing was performed to evaluate exercise capacity. The total radiotherapy dose was 50.4 Gy (1.8 Gy/fraction) to the breast or chest wall, including supraclavicular lymph nodes (SCLN) or not. Dose-volume histograms were calculated for each patient with special attention to the ipsilateral lung volume receiving 25 Gy (V25), in absolute and relative values, and mean lung dose. Results: The study comprised 37 patients. After radiotherapy, significant decreases were observed in respiratory muscle strength, chest wall mobility, exercise capacity, and pulmonary function test results (p < 0.05). DLCO was unchanged. HRCT showed changes related to radiotherapy in 87% of the patients, which was more evident in the patients submitted to SCLN irradiation. V25% significantly correlated with radiation pneumonitis. Conclusions: In our sample of patients with breast cancer, thoracic radiotherapy seemed to have caused significant losses in respiratory and exercise capacity, probably due to chest wall restriction; SCLN irradiation represented an additional risk factor for the development of radiation pneumonitis.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600469
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1806-37562017000000120
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv Jornal Brasileiro de Pneumologia v.44 n.6 2018
reponame:Jornal Brasileiro de Pneumologia (Online)
instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
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reponame_str Jornal Brasileiro de Pneumologia (Online)
collection Jornal Brasileiro de Pneumologia (Online)
repository.name.fl_str_mv Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
repository.mail.fl_str_mv ||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br
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