Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study

Detalhes bibliográficos
Autor(a) principal: Santo,Augusto Hasiak
Data de Publicação: 2021
Outros Autores: Silva-Filho,Luiz Vicente Ribeiro Ferreira da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Pneumologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132021000200202
Resumo: ABSTRACT Objective: To describe causes of death and mortality data related to cystic fibrosis (CF) using a multiple-cause-of-death methodology. Methods: Annual mortality data for the 1999-2017 period were extracted from the Brazilian National Ministry of Health Mortality Database. All death certificates in which category E84 (CF) of the ICD-10, was listed as an underlying or associated cause of death were selected. Epidemiological and clinical data were described, and standardized mortality rates were calculated per year and for the 2000-2017 period. A joinpoint regression analysis was performed to detect changes in the mortality rates during the study period. Results: Overall, 2,854 CF-related deaths were identified during the study period, ranging from 68 in 1999 to 289 in 2017. CF was the underlying cause of death in 83.5% of the death certificates. A continuous upward trend in the death rates was observed, with a significant annual percent change of 6.84% (5.3-8.4%) among males and 7.50% (6.6-8.4%) among females. The median age at death increased from 7.5 years in 1999 to 56.5 years in 2017. Diseases of the respiratory system accounted for 77% of the associated causes in the death certificates that reported CF as the underlying cause of death. Conclusions: A significant and continuous increase in CF-related death rates was found in Brazil in the last years, as well as a concurrent increase in the median age at death.
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spelling Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death studyCystic fibrosis/mortalityCause of deathDeath certificatesBrazilABSTRACT Objective: To describe causes of death and mortality data related to cystic fibrosis (CF) using a multiple-cause-of-death methodology. Methods: Annual mortality data for the 1999-2017 period were extracted from the Brazilian National Ministry of Health Mortality Database. All death certificates in which category E84 (CF) of the ICD-10, was listed as an underlying or associated cause of death were selected. Epidemiological and clinical data were described, and standardized mortality rates were calculated per year and for the 2000-2017 period. A joinpoint regression analysis was performed to detect changes in the mortality rates during the study period. Results: Overall, 2,854 CF-related deaths were identified during the study period, ranging from 68 in 1999 to 289 in 2017. CF was the underlying cause of death in 83.5% of the death certificates. A continuous upward trend in the death rates was observed, with a significant annual percent change of 6.84% (5.3-8.4%) among males and 7.50% (6.6-8.4%) among females. The median age at death increased from 7.5 years in 1999 to 56.5 years in 2017. Diseases of the respiratory system accounted for 77% of the associated causes in the death certificates that reported CF as the underlying cause of death. Conclusions: A significant and continuous increase in CF-related death rates was found in Brazil in the last years, as well as a concurrent increase in the median age at death.Sociedade Brasileira de Pneumologia e Tisiologia2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132021000200202Jornal Brasileiro de Pneumologia v.47 n.2 2021reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.36416/1806-3756/e20200166info:eu-repo/semantics/openAccessSanto,Augusto HasiakSilva-Filho,Luiz Vicente Ribeiro Ferreira daeng2021-02-22T00:00:00Zoai:scielo:S1806-37132021000200202Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2021-02-22T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false
dc.title.none.fl_str_mv Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study
title Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study
spellingShingle Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study
Santo,Augusto Hasiak
Cystic fibrosis/mortality
Cause of death
Death certificates
Brazil
title_short Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study
title_full Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study
title_fullStr Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study
title_full_unstemmed Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study
title_sort Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study
author Santo,Augusto Hasiak
author_facet Santo,Augusto Hasiak
Silva-Filho,Luiz Vicente Ribeiro Ferreira da
author_role author
author2 Silva-Filho,Luiz Vicente Ribeiro Ferreira da
author2_role author
dc.contributor.author.fl_str_mv Santo,Augusto Hasiak
Silva-Filho,Luiz Vicente Ribeiro Ferreira da
dc.subject.por.fl_str_mv Cystic fibrosis/mortality
Cause of death
Death certificates
Brazil
topic Cystic fibrosis/mortality
Cause of death
Death certificates
Brazil
description ABSTRACT Objective: To describe causes of death and mortality data related to cystic fibrosis (CF) using a multiple-cause-of-death methodology. Methods: Annual mortality data for the 1999-2017 period were extracted from the Brazilian National Ministry of Health Mortality Database. All death certificates in which category E84 (CF) of the ICD-10, was listed as an underlying or associated cause of death were selected. Epidemiological and clinical data were described, and standardized mortality rates were calculated per year and for the 2000-2017 period. A joinpoint regression analysis was performed to detect changes in the mortality rates during the study period. Results: Overall, 2,854 CF-related deaths were identified during the study period, ranging from 68 in 1999 to 289 in 2017. CF was the underlying cause of death in 83.5% of the death certificates. A continuous upward trend in the death rates was observed, with a significant annual percent change of 6.84% (5.3-8.4%) among males and 7.50% (6.6-8.4%) among females. The median age at death increased from 7.5 years in 1999 to 56.5 years in 2017. Diseases of the respiratory system accounted for 77% of the associated causes in the death certificates that reported CF as the underlying cause of death. Conclusions: A significant and continuous increase in CF-related death rates was found in Brazil in the last years, as well as a concurrent increase in the median age at death.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
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dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv Jornal Brasileiro de Pneumologia v.47 n.2 2021
reponame:Jornal Brasileiro de Pneumologia (Online)
instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
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