Latent tuberculosis infection in patients with rheumatic diseases
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Pneumologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000200502 |
Resumo: | ABSTRACT Most people infected by Mycobacterium tuberculosis (Mtb) do not have any signs or disease symptoms, a condition known as latent tuberculosis infection (LTBI). The introduction of biological agents, mainly tumor necrosis factor (TNF) inhibitors, for the treatment of immune-mediated diseases such as Rheumatoid Arthritis (RA) and other rheumatic diseases, increased the risk of reactivation of LTBI, leading to development of active TB. Thus, this review will approach the aspects related to LTBI in patients with rheumatologic diseases, especially those using iTNF drugs. For this purpose it will be considered the definition and prevalence of LTBI, mechanisms associated with diseases and medications in use, criteria for screening, diagnosis and treatment. Considering that reactivation of LTBI accounts for a large proportion of the incidence of active TB, adequate diagnosis and treatment are crucial, especially in high-risk groups such as patients with rheumatologic diseases. |
id |
SBPT-1_2fe13db9b7e8097c5b375affb6b59a6f |
---|---|
oai_identifier_str |
oai:scielo:S1806-37132019000200502 |
network_acronym_str |
SBPT-1 |
network_name_str |
Jornal Brasileiro de Pneumologia (Online) |
repository_id_str |
|
spelling |
Latent tuberculosis infection in patients with rheumatic diseasesTuberculosisLatent tuberculosisTuberculin skin testAnti-TNF therapyTumor necrosis factor-alphaRheumatoid arthritisABSTRACT Most people infected by Mycobacterium tuberculosis (Mtb) do not have any signs or disease symptoms, a condition known as latent tuberculosis infection (LTBI). The introduction of biological agents, mainly tumor necrosis factor (TNF) inhibitors, for the treatment of immune-mediated diseases such as Rheumatoid Arthritis (RA) and other rheumatic diseases, increased the risk of reactivation of LTBI, leading to development of active TB. Thus, this review will approach the aspects related to LTBI in patients with rheumatologic diseases, especially those using iTNF drugs. For this purpose it will be considered the definition and prevalence of LTBI, mechanisms associated with diseases and medications in use, criteria for screening, diagnosis and treatment. Considering that reactivation of LTBI accounts for a large proportion of the incidence of active TB, adequate diagnosis and treatment are crucial, especially in high-risk groups such as patients with rheumatologic diseases.Sociedade Brasileira de Pneumologia e Tisiologia2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000200502Jornal Brasileiro de Pneumologia v.45 n.2 2019reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/1806-3713/e20190023info:eu-repo/semantics/openAccessAnton,CamilaMachado,Felipe DominguezRamirez,Jorge Mario AhumadaBernardi,Rafaela ManzoniPalominos,Penélope EstherBrenol,Claiton ViegasMello,Fernanda Carvalho de QueirozSilva,Denise Rossatoeng2019-04-18T00:00:00Zoai:scielo:S1806-37132019000200502Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2019-04-18T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false |
dc.title.none.fl_str_mv |
Latent tuberculosis infection in patients with rheumatic diseases |
title |
Latent tuberculosis infection in patients with rheumatic diseases |
spellingShingle |
Latent tuberculosis infection in patients with rheumatic diseases Anton,Camila Tuberculosis Latent tuberculosis Tuberculin skin test Anti-TNF therapy Tumor necrosis factor-alpha Rheumatoid arthritis |
title_short |
Latent tuberculosis infection in patients with rheumatic diseases |
title_full |
Latent tuberculosis infection in patients with rheumatic diseases |
title_fullStr |
Latent tuberculosis infection in patients with rheumatic diseases |
title_full_unstemmed |
Latent tuberculosis infection in patients with rheumatic diseases |
title_sort |
Latent tuberculosis infection in patients with rheumatic diseases |
author |
Anton,Camila |
author_facet |
Anton,Camila Machado,Felipe Dominguez Ramirez,Jorge Mario Ahumada Bernardi,Rafaela Manzoni Palominos,Penélope Esther Brenol,Claiton Viegas Mello,Fernanda Carvalho de Queiroz Silva,Denise Rossato |
author_role |
author |
author2 |
Machado,Felipe Dominguez Ramirez,Jorge Mario Ahumada Bernardi,Rafaela Manzoni Palominos,Penélope Esther Brenol,Claiton Viegas Mello,Fernanda Carvalho de Queiroz Silva,Denise Rossato |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Anton,Camila Machado,Felipe Dominguez Ramirez,Jorge Mario Ahumada Bernardi,Rafaela Manzoni Palominos,Penélope Esther Brenol,Claiton Viegas Mello,Fernanda Carvalho de Queiroz Silva,Denise Rossato |
dc.subject.por.fl_str_mv |
Tuberculosis Latent tuberculosis Tuberculin skin test Anti-TNF therapy Tumor necrosis factor-alpha Rheumatoid arthritis |
topic |
Tuberculosis Latent tuberculosis Tuberculin skin test Anti-TNF therapy Tumor necrosis factor-alpha Rheumatoid arthritis |
description |
ABSTRACT Most people infected by Mycobacterium tuberculosis (Mtb) do not have any signs or disease symptoms, a condition known as latent tuberculosis infection (LTBI). The introduction of biological agents, mainly tumor necrosis factor (TNF) inhibitors, for the treatment of immune-mediated diseases such as Rheumatoid Arthritis (RA) and other rheumatic diseases, increased the risk of reactivation of LTBI, leading to development of active TB. Thus, this review will approach the aspects related to LTBI in patients with rheumatologic diseases, especially those using iTNF drugs. For this purpose it will be considered the definition and prevalence of LTBI, mechanisms associated with diseases and medications in use, criteria for screening, diagnosis and treatment. Considering that reactivation of LTBI accounts for a large proportion of the incidence of active TB, adequate diagnosis and treatment are crucial, especially in high-risk groups such as patients with rheumatologic diseases. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000200502 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000200502 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-3713/e20190023 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Pneumologia v.45 n.2 2019 reponame:Jornal Brasileiro de Pneumologia (Online) instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) instacron:SBPT |
instname_str |
Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
instacron_str |
SBPT |
institution |
SBPT |
reponame_str |
Jornal Brasileiro de Pneumologia (Online) |
collection |
Jornal Brasileiro de Pneumologia (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
repository.mail.fl_str_mv |
||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br |
_version_ |
1750318347342315520 |