Obesity and asthma: clinical and laboratory characterization of a common combination

Detalhes bibliográficos
Autor(a) principal: Jesus,Juliana Pires Viana de
Data de Publicação: 2018
Outros Autores: Lima-Matos,Aline Silva, Almeida,Paula Cristina Andrade, Lima,Valmar Bião, Mello,Luane Marques de, Souza-Machado,Adelmir, Ponte,Eduardo Vieira, Cruz,Álvaro Augusto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Pneumologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000300207
Resumo: ABSTRACT Objective: To evaluate the relationship between obesity and asthma. Methods: This was a preliminary cross-sectional analysis involving 925 subjects with mild-to-moderate or severe asthma evaluated between 2013 and 2015. Obesity was defined on the basis of body mass index (BMI) and abdominal circumference. We collected clinical, laboratory, and anthropometric parameters, as well as pulmonary function test results and data regarding comorbidities. The subjects also completed asthma control and quality of life questionnaires. Results: Obese individuals had a significantly higher number of neutrophils in peripheral blood than did nonobese individuals (p = 0.01). Among the obese individuals, 163 (61%) had positive skin-prick test results, as did 69% and 71% of the individuals classified as being overweight or normal weight, respectively. Obese individuals showed lower spirometric values than did nonobese individuals, and 32% of the obese individuals had uncontrolled asthma, a significantly higher proportion than that found in the other groups (p = 0.02). Conclusions: Obese individuals with asthma seem to present with poorer asthma control and lower pulmonary function values than do nonobese individuals. The proportion of subjects with nonatopic asthma was higher in the obese group. Our results suggest that obese individuals with asthma show a distinct inflammatory pattern and are more likely to present with difficult-to-control asthma than are nonobese individuals.
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spelling Obesity and asthma: clinical and laboratory characterization of a common combinationAsthmaObesityOverweightEosinophiliaABSTRACT Objective: To evaluate the relationship between obesity and asthma. Methods: This was a preliminary cross-sectional analysis involving 925 subjects with mild-to-moderate or severe asthma evaluated between 2013 and 2015. Obesity was defined on the basis of body mass index (BMI) and abdominal circumference. We collected clinical, laboratory, and anthropometric parameters, as well as pulmonary function test results and data regarding comorbidities. The subjects also completed asthma control and quality of life questionnaires. Results: Obese individuals had a significantly higher number of neutrophils in peripheral blood than did nonobese individuals (p = 0.01). Among the obese individuals, 163 (61%) had positive skin-prick test results, as did 69% and 71% of the individuals classified as being overweight or normal weight, respectively. Obese individuals showed lower spirometric values than did nonobese individuals, and 32% of the obese individuals had uncontrolled asthma, a significantly higher proportion than that found in the other groups (p = 0.02). Conclusions: Obese individuals with asthma seem to present with poorer asthma control and lower pulmonary function values than do nonobese individuals. The proportion of subjects with nonatopic asthma was higher in the obese group. Our results suggest that obese individuals with asthma show a distinct inflammatory pattern and are more likely to present with difficult-to-control asthma than are nonobese individuals.Sociedade Brasileira de Pneumologia e Tisiologia2018-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000300207Jornal Brasileiro de Pneumologia v.44 n.3 2018reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/s1806-37562017000000034info:eu-repo/semantics/openAccessJesus,Juliana Pires Viana deLima-Matos,Aline SilvaAlmeida,Paula Cristina AndradeLima,Valmar BiãoMello,Luane Marques deSouza-Machado,AdelmirPonte,Eduardo VieiraCruz,Álvaro Augustoeng2018-07-16T00:00:00Zoai:scielo:S1806-37132018000300207Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2018-07-16T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false
dc.title.none.fl_str_mv Obesity and asthma: clinical and laboratory characterization of a common combination
title Obesity and asthma: clinical and laboratory characterization of a common combination
spellingShingle Obesity and asthma: clinical and laboratory characterization of a common combination
Jesus,Juliana Pires Viana de
Asthma
Obesity
Overweight
Eosinophilia
title_short Obesity and asthma: clinical and laboratory characterization of a common combination
title_full Obesity and asthma: clinical and laboratory characterization of a common combination
title_fullStr Obesity and asthma: clinical and laboratory characterization of a common combination
title_full_unstemmed Obesity and asthma: clinical and laboratory characterization of a common combination
title_sort Obesity and asthma: clinical and laboratory characterization of a common combination
author Jesus,Juliana Pires Viana de
author_facet Jesus,Juliana Pires Viana de
Lima-Matos,Aline Silva
Almeida,Paula Cristina Andrade
Lima,Valmar Bião
Mello,Luane Marques de
Souza-Machado,Adelmir
Ponte,Eduardo Vieira
Cruz,Álvaro Augusto
author_role author
author2 Lima-Matos,Aline Silva
Almeida,Paula Cristina Andrade
Lima,Valmar Bião
Mello,Luane Marques de
Souza-Machado,Adelmir
Ponte,Eduardo Vieira
Cruz,Álvaro Augusto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jesus,Juliana Pires Viana de
Lima-Matos,Aline Silva
Almeida,Paula Cristina Andrade
Lima,Valmar Bião
Mello,Luane Marques de
Souza-Machado,Adelmir
Ponte,Eduardo Vieira
Cruz,Álvaro Augusto
dc.subject.por.fl_str_mv Asthma
Obesity
Overweight
Eosinophilia
topic Asthma
Obesity
Overweight
Eosinophilia
description ABSTRACT Objective: To evaluate the relationship between obesity and asthma. Methods: This was a preliminary cross-sectional analysis involving 925 subjects with mild-to-moderate or severe asthma evaluated between 2013 and 2015. Obesity was defined on the basis of body mass index (BMI) and abdominal circumference. We collected clinical, laboratory, and anthropometric parameters, as well as pulmonary function test results and data regarding comorbidities. The subjects also completed asthma control and quality of life questionnaires. Results: Obese individuals had a significantly higher number of neutrophils in peripheral blood than did nonobese individuals (p = 0.01). Among the obese individuals, 163 (61%) had positive skin-prick test results, as did 69% and 71% of the individuals classified as being overweight or normal weight, respectively. Obese individuals showed lower spirometric values than did nonobese individuals, and 32% of the obese individuals had uncontrolled asthma, a significantly higher proportion than that found in the other groups (p = 0.02). Conclusions: Obese individuals with asthma seem to present with poorer asthma control and lower pulmonary function values than do nonobese individuals. The proportion of subjects with nonatopic asthma was higher in the obese group. Our results suggest that obese individuals with asthma show a distinct inflammatory pattern and are more likely to present with difficult-to-control asthma than are nonobese individuals.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1806-37562017000000034
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv Jornal Brasileiro de Pneumologia v.44 n.3 2018
reponame:Jornal Brasileiro de Pneumologia (Online)
instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
instacron:SBPT
instname_str Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
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institution SBPT
reponame_str Jornal Brasileiro de Pneumologia (Online)
collection Jornal Brasileiro de Pneumologia (Online)
repository.name.fl_str_mv Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
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