Nocturnal hypoxemia in children and adolescents with cystic fibrosis

Detalhes bibliográficos
Autor(a) principal: Ramos,Regina Terse Trindade
Data de Publicação: 2013
Outros Autores: Santana,Maria Angélica Pinheiro, Almeida,Priscila de Carvalho, Machado Júnior,Almério de Souza, Araújo-Filho,José Bouzas, Salles,Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Pneumologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132013000600667
Resumo: OBJECTIVE: To determine the prevalence of nocturnal hypoxemia and its association with pulmonary function, nutritional status, sleep macrostructure, and obstructive respiratory events during sleep in a population of clinically stable children and adolescents with cystic fibrosis (CF).METHODS: This was a cross-sectional study involving 67 children and adolescents with CF between 2 and 14 years of age. All of the participants underwent polysomnography, and SpO2 was measured by pulse oximetry. We also evaluated the Shwachman-Kulczycki (S-K) scores, spirometry findings, and nutritional status of the patients.RESULTS: The study involved 67 patients. The mean age of the patients was 8 years. The S-K scores differed significantly between the patients with and without nocturnal hypoxemia, which was defined as an SpO2 < 90% for more than 5% of the total sleep time (73.75 ± 6.29 vs. 86.38 ± 8.70; p < 0.01). Nocturnal hypoxemia correlated with the severity of lung disease, FEV1 (rs= −0.42; p = 0.01), FVC (rs= −0.46; p = 0.01), microarousal index (rs= 0.32; p = 0.01), and apnea-hypopnea index (rs = 0.56; p = 0.01).CONCLUSIONS: In this sample of patients with CF and mild-to-moderate lung disease, nocturnal oxygenation correlated with the S-K score, spirometry variables, sleep macrostructure variables, and the apnea-hypopnea index.
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spelling Nocturnal hypoxemia in children and adolescents with cystic fibrosisCystic fibrosisSleepOximetryOBJECTIVE: To determine the prevalence of nocturnal hypoxemia and its association with pulmonary function, nutritional status, sleep macrostructure, and obstructive respiratory events during sleep in a population of clinically stable children and adolescents with cystic fibrosis (CF).METHODS: This was a cross-sectional study involving 67 children and adolescents with CF between 2 and 14 years of age. All of the participants underwent polysomnography, and SpO2 was measured by pulse oximetry. We also evaluated the Shwachman-Kulczycki (S-K) scores, spirometry findings, and nutritional status of the patients.RESULTS: The study involved 67 patients. The mean age of the patients was 8 years. The S-K scores differed significantly between the patients with and without nocturnal hypoxemia, which was defined as an SpO2 < 90% for more than 5% of the total sleep time (73.75 ± 6.29 vs. 86.38 ± 8.70; p < 0.01). Nocturnal hypoxemia correlated with the severity of lung disease, FEV1 (rs= −0.42; p = 0.01), FVC (rs= −0.46; p = 0.01), microarousal index (rs= 0.32; p = 0.01), and apnea-hypopnea index (rs = 0.56; p = 0.01).CONCLUSIONS: In this sample of patients with CF and mild-to-moderate lung disease, nocturnal oxygenation correlated with the S-K score, spirometry variables, sleep macrostructure variables, and the apnea-hypopnea index.Sociedade Brasileira de Pneumologia e Tisiologia2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132013000600667Jornal Brasileiro de Pneumologia v.39 n.6 2013reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/S1806-37132013000600005info:eu-repo/semantics/openAccessRamos,Regina Terse TrindadeSantana,Maria Angélica PinheiroAlmeida,Priscila de CarvalhoMachado Júnior,Almério de SouzaAraújo-Filho,José BouzasSalles,Cristinaeng2015-10-27T00:00:00Zoai:scielo:S1806-37132013000600667Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2015-10-27T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false
dc.title.none.fl_str_mv Nocturnal hypoxemia in children and adolescents with cystic fibrosis
title Nocturnal hypoxemia in children and adolescents with cystic fibrosis
spellingShingle Nocturnal hypoxemia in children and adolescents with cystic fibrosis
Ramos,Regina Terse Trindade
Cystic fibrosis
Sleep
Oximetry
title_short Nocturnal hypoxemia in children and adolescents with cystic fibrosis
title_full Nocturnal hypoxemia in children and adolescents with cystic fibrosis
title_fullStr Nocturnal hypoxemia in children and adolescents with cystic fibrosis
title_full_unstemmed Nocturnal hypoxemia in children and adolescents with cystic fibrosis
title_sort Nocturnal hypoxemia in children and adolescents with cystic fibrosis
author Ramos,Regina Terse Trindade
author_facet Ramos,Regina Terse Trindade
Santana,Maria Angélica Pinheiro
Almeida,Priscila de Carvalho
Machado Júnior,Almério de Souza
Araújo-Filho,José Bouzas
Salles,Cristina
author_role author
author2 Santana,Maria Angélica Pinheiro
Almeida,Priscila de Carvalho
Machado Júnior,Almério de Souza
Araújo-Filho,José Bouzas
Salles,Cristina
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ramos,Regina Terse Trindade
Santana,Maria Angélica Pinheiro
Almeida,Priscila de Carvalho
Machado Júnior,Almério de Souza
Araújo-Filho,José Bouzas
Salles,Cristina
dc.subject.por.fl_str_mv Cystic fibrosis
Sleep
Oximetry
topic Cystic fibrosis
Sleep
Oximetry
description OBJECTIVE: To determine the prevalence of nocturnal hypoxemia and its association with pulmonary function, nutritional status, sleep macrostructure, and obstructive respiratory events during sleep in a population of clinically stable children and adolescents with cystic fibrosis (CF).METHODS: This was a cross-sectional study involving 67 children and adolescents with CF between 2 and 14 years of age. All of the participants underwent polysomnography, and SpO2 was measured by pulse oximetry. We also evaluated the Shwachman-Kulczycki (S-K) scores, spirometry findings, and nutritional status of the patients.RESULTS: The study involved 67 patients. The mean age of the patients was 8 years. The S-K scores differed significantly between the patients with and without nocturnal hypoxemia, which was defined as an SpO2 < 90% for more than 5% of the total sleep time (73.75 ± 6.29 vs. 86.38 ± 8.70; p < 0.01). Nocturnal hypoxemia correlated with the severity of lung disease, FEV1 (rs= −0.42; p = 0.01), FVC (rs= −0.46; p = 0.01), microarousal index (rs= 0.32; p = 0.01), and apnea-hypopnea index (rs = 0.56; p = 0.01).CONCLUSIONS: In this sample of patients with CF and mild-to-moderate lung disease, nocturnal oxygenation correlated with the S-K score, spirometry variables, sleep macrostructure variables, and the apnea-hypopnea index.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1806-37132013000600005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv Jornal Brasileiro de Pneumologia v.39 n.6 2013
reponame:Jornal Brasileiro de Pneumologia (Online)
instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
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reponame_str Jornal Brasileiro de Pneumologia (Online)
collection Jornal Brasileiro de Pneumologia (Online)
repository.name.fl_str_mv Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
repository.mail.fl_str_mv ||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br
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