Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Pneumologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600505 |
Resumo: | ABSTRACT Objective: To evaluate different weight loss (WL) cut-off points as prognostic markers of 3-month survival after diagnosis of stage IV non-small cell lung cancer (NSCLC). Methods: This was a prospective study involving 104 patients with metastatic (stage IV) NSCLC who were admitted to a cancer treatment center in southern Brazil between January of 2014 and November of 2016. We evaluated total WL and WL per month, as well as WL and WL per month in the 6 months preceding the diagnosis. The patients were followed for 3 months after diagnosis. A Cox proportional hazards regression model and Kaplan-Meier curves were used in order to evaluate 3-month survival. Results: The median WL in the 6 months preceding the diagnosis was 6% (interquartile range, 0.0-12.9%). Patients with WL ≥ 5% had a median survival of 78 days, compared with 85 days for those with WL < 5% (p = 0.047). Survival at 3 months was 72% for the patients with WL ≥ 5% (p = 0.047), 61% for those with WL ≥ 10% (p < 0.001), and 45% for those with WL ≥ 15% (p < 0.001). In the multivariate analysis, the hazard ratio for risk of death was 4.51 (95% CI: 1.32-15.39) for the patients with WL ≥ 5%, 6.34 (95% CI: 2.31-17.40) for those with WL ≥ 10%, and 14.17 (95% CI: 5.06-39.65) for those with WL ≥ 15%. Conclusions: WL in the 6 months preceding the diagnosis of NSCLC is a relevant prognostic factor and appears to be directly proportional to the rate of survival at 3 months. |
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Jornal Brasileiro de Pneumologia (Online) |
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Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancerWeight lossCarcinoma, non-small-cell lungPrognosisABSTRACT Objective: To evaluate different weight loss (WL) cut-off points as prognostic markers of 3-month survival after diagnosis of stage IV non-small cell lung cancer (NSCLC). Methods: This was a prospective study involving 104 patients with metastatic (stage IV) NSCLC who were admitted to a cancer treatment center in southern Brazil between January of 2014 and November of 2016. We evaluated total WL and WL per month, as well as WL and WL per month in the 6 months preceding the diagnosis. The patients were followed for 3 months after diagnosis. A Cox proportional hazards regression model and Kaplan-Meier curves were used in order to evaluate 3-month survival. Results: The median WL in the 6 months preceding the diagnosis was 6% (interquartile range, 0.0-12.9%). Patients with WL ≥ 5% had a median survival of 78 days, compared with 85 days for those with WL < 5% (p = 0.047). Survival at 3 months was 72% for the patients with WL ≥ 5% (p = 0.047), 61% for those with WL ≥ 10% (p < 0.001), and 45% for those with WL ≥ 15% (p < 0.001). In the multivariate analysis, the hazard ratio for risk of death was 4.51 (95% CI: 1.32-15.39) for the patients with WL ≥ 5%, 6.34 (95% CI: 2.31-17.40) for those with WL ≥ 10%, and 14.17 (95% CI: 5.06-39.65) for those with WL ≥ 15%. Conclusions: WL in the 6 months preceding the diagnosis of NSCLC is a relevant prognostic factor and appears to be directly proportional to the rate of survival at 3 months.Sociedade Brasileira de Pneumologia e Tisiologia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600505Jornal Brasileiro de Pneumologia v.44 n.6 2018reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/s1806-37562018000000023info:eu-repo/semantics/openAccessWatte,GuilhermeNunes,Claudia Helena de AbreuSidney-Filho,Luzielio AlvesZanon,MatheusAltmayer,Stephan Philip LeonhardtPacini,Gabriel SartoriBarros,MarceloMoreira,Ana Luiza SchneiderAlves,Rafael José VargasZelmanowicz,Alice de MedeirosMatata,Bashir MneneMoreira,Jose da Silvaeng2019-01-29T00:00:00Zoai:scielo:S1806-37132018000600505Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2019-01-29T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false |
dc.title.none.fl_str_mv |
Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer |
title |
Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer |
spellingShingle |
Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer Watte,Guilherme Weight loss Carcinoma, non-small-cell lung Prognosis |
title_short |
Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer |
title_full |
Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer |
title_fullStr |
Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer |
title_full_unstemmed |
Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer |
title_sort |
Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer |
author |
Watte,Guilherme |
author_facet |
Watte,Guilherme Nunes,Claudia Helena de Abreu Sidney-Filho,Luzielio Alves Zanon,Matheus Altmayer,Stephan Philip Leonhardt Pacini,Gabriel Sartori Barros,Marcelo Moreira,Ana Luiza Schneider Alves,Rafael José Vargas Zelmanowicz,Alice de Medeiros Matata,Bashir Mnene Moreira,Jose da Silva |
author_role |
author |
author2 |
Nunes,Claudia Helena de Abreu Sidney-Filho,Luzielio Alves Zanon,Matheus Altmayer,Stephan Philip Leonhardt Pacini,Gabriel Sartori Barros,Marcelo Moreira,Ana Luiza Schneider Alves,Rafael José Vargas Zelmanowicz,Alice de Medeiros Matata,Bashir Mnene Moreira,Jose da Silva |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Watte,Guilherme Nunes,Claudia Helena de Abreu Sidney-Filho,Luzielio Alves Zanon,Matheus Altmayer,Stephan Philip Leonhardt Pacini,Gabriel Sartori Barros,Marcelo Moreira,Ana Luiza Schneider Alves,Rafael José Vargas Zelmanowicz,Alice de Medeiros Matata,Bashir Mnene Moreira,Jose da Silva |
dc.subject.por.fl_str_mv |
Weight loss Carcinoma, non-small-cell lung Prognosis |
topic |
Weight loss Carcinoma, non-small-cell lung Prognosis |
description |
ABSTRACT Objective: To evaluate different weight loss (WL) cut-off points as prognostic markers of 3-month survival after diagnosis of stage IV non-small cell lung cancer (NSCLC). Methods: This was a prospective study involving 104 patients with metastatic (stage IV) NSCLC who were admitted to a cancer treatment center in southern Brazil between January of 2014 and November of 2016. We evaluated total WL and WL per month, as well as WL and WL per month in the 6 months preceding the diagnosis. The patients were followed for 3 months after diagnosis. A Cox proportional hazards regression model and Kaplan-Meier curves were used in order to evaluate 3-month survival. Results: The median WL in the 6 months preceding the diagnosis was 6% (interquartile range, 0.0-12.9%). Patients with WL ≥ 5% had a median survival of 78 days, compared with 85 days for those with WL < 5% (p = 0.047). Survival at 3 months was 72% for the patients with WL ≥ 5% (p = 0.047), 61% for those with WL ≥ 10% (p < 0.001), and 45% for those with WL ≥ 15% (p < 0.001). In the multivariate analysis, the hazard ratio for risk of death was 4.51 (95% CI: 1.32-15.39) for the patients with WL ≥ 5%, 6.34 (95% CI: 2.31-17.40) for those with WL ≥ 10%, and 14.17 (95% CI: 5.06-39.65) for those with WL ≥ 15%. Conclusions: WL in the 6 months preceding the diagnosis of NSCLC is a relevant prognostic factor and appears to be directly proportional to the rate of survival at 3 months. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600505 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600505 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1806-37562018000000023 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Pneumologia v.44 n.6 2018 reponame:Jornal Brasileiro de Pneumologia (Online) instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) instacron:SBPT |
instname_str |
Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
instacron_str |
SBPT |
institution |
SBPT |
reponame_str |
Jornal Brasileiro de Pneumologia (Online) |
collection |
Jornal Brasileiro de Pneumologia (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
repository.mail.fl_str_mv |
||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br |
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1750318347286740992 |