Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer

Detalhes bibliográficos
Autor(a) principal: Watte,Guilherme
Data de Publicação: 2018
Outros Autores: Nunes,Claudia Helena de Abreu, Sidney-Filho,Luzielio Alves, Zanon,Matheus, Altmayer,Stephan Philip Leonhardt, Pacini,Gabriel Sartori, Barros,Marcelo, Moreira,Ana Luiza Schneider, Alves,Rafael José Vargas, Zelmanowicz,Alice de Medeiros, Matata,Bashir Mnene, Moreira,Jose da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Pneumologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600505
Resumo: ABSTRACT Objective: To evaluate different weight loss (WL) cut-off points as prognostic markers of 3-month survival after diagnosis of stage IV non-small cell lung cancer (NSCLC). Methods: This was a prospective study involving 104 patients with metastatic (stage IV) NSCLC who were admitted to a cancer treatment center in southern Brazil between January of 2014 and November of 2016. We evaluated total WL and WL per month, as well as WL and WL per month in the 6 months preceding the diagnosis. The patients were followed for 3 months after diagnosis. A Cox proportional hazards regression model and Kaplan-Meier curves were used in order to evaluate 3-month survival. Results: The median WL in the 6 months preceding the diagnosis was 6% (interquartile range, 0.0-12.9%). Patients with WL ≥ 5% had a median survival of 78 days, compared with 85 days for those with WL < 5% (p = 0.047). Survival at 3 months was 72% for the patients with WL ≥ 5% (p = 0.047), 61% for those with WL ≥ 10% (p < 0.001), and 45% for those with WL ≥ 15% (p < 0.001). In the multivariate analysis, the hazard ratio for risk of death was 4.51 (95% CI: 1.32-15.39) for the patients with WL ≥ 5%, 6.34 (95% CI: 2.31-17.40) for those with WL ≥ 10%, and 14.17 (95% CI: 5.06-39.65) for those with WL ≥ 15%. Conclusions: WL in the 6 months preceding the diagnosis of NSCLC is a relevant prognostic factor and appears to be directly proportional to the rate of survival at 3 months.
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spelling Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancerWeight lossCarcinoma, non-small-cell lungPrognosisABSTRACT Objective: To evaluate different weight loss (WL) cut-off points as prognostic markers of 3-month survival after diagnosis of stage IV non-small cell lung cancer (NSCLC). Methods: This was a prospective study involving 104 patients with metastatic (stage IV) NSCLC who were admitted to a cancer treatment center in southern Brazil between January of 2014 and November of 2016. We evaluated total WL and WL per month, as well as WL and WL per month in the 6 months preceding the diagnosis. The patients were followed for 3 months after diagnosis. A Cox proportional hazards regression model and Kaplan-Meier curves were used in order to evaluate 3-month survival. Results: The median WL in the 6 months preceding the diagnosis was 6% (interquartile range, 0.0-12.9%). Patients with WL ≥ 5% had a median survival of 78 days, compared with 85 days for those with WL < 5% (p = 0.047). Survival at 3 months was 72% for the patients with WL ≥ 5% (p = 0.047), 61% for those with WL ≥ 10% (p < 0.001), and 45% for those with WL ≥ 15% (p < 0.001). In the multivariate analysis, the hazard ratio for risk of death was 4.51 (95% CI: 1.32-15.39) for the patients with WL ≥ 5%, 6.34 (95% CI: 2.31-17.40) for those with WL ≥ 10%, and 14.17 (95% CI: 5.06-39.65) for those with WL ≥ 15%. Conclusions: WL in the 6 months preceding the diagnosis of NSCLC is a relevant prognostic factor and appears to be directly proportional to the rate of survival at 3 months.Sociedade Brasileira de Pneumologia e Tisiologia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600505Jornal Brasileiro de Pneumologia v.44 n.6 2018reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/s1806-37562018000000023info:eu-repo/semantics/openAccessWatte,GuilhermeNunes,Claudia Helena de AbreuSidney-Filho,Luzielio AlvesZanon,MatheusAltmayer,Stephan Philip LeonhardtPacini,Gabriel SartoriBarros,MarceloMoreira,Ana Luiza SchneiderAlves,Rafael José VargasZelmanowicz,Alice de MedeirosMatata,Bashir MneneMoreira,Jose da Silvaeng2019-01-29T00:00:00Zoai:scielo:S1806-37132018000600505Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2019-01-29T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false
dc.title.none.fl_str_mv Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer
title Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer
spellingShingle Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer
Watte,Guilherme
Weight loss
Carcinoma, non-small-cell lung
Prognosis
title_short Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer
title_full Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer
title_fullStr Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer
title_full_unstemmed Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer
title_sort Proportional weight loss in six months as a risk factor for mortality in stage IV non-small cell lung cancer
author Watte,Guilherme
author_facet Watte,Guilherme
Nunes,Claudia Helena de Abreu
Sidney-Filho,Luzielio Alves
Zanon,Matheus
Altmayer,Stephan Philip Leonhardt
Pacini,Gabriel Sartori
Barros,Marcelo
Moreira,Ana Luiza Schneider
Alves,Rafael José Vargas
Zelmanowicz,Alice de Medeiros
Matata,Bashir Mnene
Moreira,Jose da Silva
author_role author
author2 Nunes,Claudia Helena de Abreu
Sidney-Filho,Luzielio Alves
Zanon,Matheus
Altmayer,Stephan Philip Leonhardt
Pacini,Gabriel Sartori
Barros,Marcelo
Moreira,Ana Luiza Schneider
Alves,Rafael José Vargas
Zelmanowicz,Alice de Medeiros
Matata,Bashir Mnene
Moreira,Jose da Silva
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Watte,Guilherme
Nunes,Claudia Helena de Abreu
Sidney-Filho,Luzielio Alves
Zanon,Matheus
Altmayer,Stephan Philip Leonhardt
Pacini,Gabriel Sartori
Barros,Marcelo
Moreira,Ana Luiza Schneider
Alves,Rafael José Vargas
Zelmanowicz,Alice de Medeiros
Matata,Bashir Mnene
Moreira,Jose da Silva
dc.subject.por.fl_str_mv Weight loss
Carcinoma, non-small-cell lung
Prognosis
topic Weight loss
Carcinoma, non-small-cell lung
Prognosis
description ABSTRACT Objective: To evaluate different weight loss (WL) cut-off points as prognostic markers of 3-month survival after diagnosis of stage IV non-small cell lung cancer (NSCLC). Methods: This was a prospective study involving 104 patients with metastatic (stage IV) NSCLC who were admitted to a cancer treatment center in southern Brazil between January of 2014 and November of 2016. We evaluated total WL and WL per month, as well as WL and WL per month in the 6 months preceding the diagnosis. The patients were followed for 3 months after diagnosis. A Cox proportional hazards regression model and Kaplan-Meier curves were used in order to evaluate 3-month survival. Results: The median WL in the 6 months preceding the diagnosis was 6% (interquartile range, 0.0-12.9%). Patients with WL ≥ 5% had a median survival of 78 days, compared with 85 days for those with WL < 5% (p = 0.047). Survival at 3 months was 72% for the patients with WL ≥ 5% (p = 0.047), 61% for those with WL ≥ 10% (p < 0.001), and 45% for those with WL ≥ 15% (p < 0.001). In the multivariate analysis, the hazard ratio for risk of death was 4.51 (95% CI: 1.32-15.39) for the patients with WL ≥ 5%, 6.34 (95% CI: 2.31-17.40) for those with WL ≥ 10%, and 14.17 (95% CI: 5.06-39.65) for those with WL ≥ 15%. Conclusions: WL in the 6 months preceding the diagnosis of NSCLC is a relevant prognostic factor and appears to be directly proportional to the rate of survival at 3 months.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000600505
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1806-37562018000000023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv Jornal Brasileiro de Pneumologia v.44 n.6 2018
reponame:Jornal Brasileiro de Pneumologia (Online)
instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
instacron:SBPT
instname_str Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
instacron_str SBPT
institution SBPT
reponame_str Jornal Brasileiro de Pneumologia (Online)
collection Jornal Brasileiro de Pneumologia (Online)
repository.name.fl_str_mv Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
repository.mail.fl_str_mv ||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br
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