Risk factors for recurrent wheezing in preterm infants who received prophylaxis with palivizumab

• Autor(a) principal: Manini,Mariana Bueno
• Data de Publicação: 2021
• Outros Autores: Matsunaga,Natasha Yumi, Gianfrancesco,Lívea, Oliveira,Marina Simões, Carvalho,Maria Rosa Vieira de, Ribeiro,Gisleine Leila Martins Tengler, Morais,Eliane de Oliveira, Ribeiro,Maria Angela Gonçalves O., Morcillo,André Moreno, Ribeiro,José Dirceu, Toro,Adyléia Aparecida Dalbo Contrera
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Jornal Brasileiro de Pneumologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132021000500204
• topic: Infant, premature; Respiratory sounds; Asthma; Palivizumab; respiratory syncytial viruses; Respiratory hypersensitivity

ABSTRACT Objective: To determine the prevalence of recurrent wheezing (RW) in preterm infants who received prophylaxis against severe infection with respiratory syncytial virus (RSV) and to identify genetic susceptibility (atopy or asthma) and risk factors for RW. Methods: This was a cross-sectional study involving preterm infants who received prophylaxis with palivizumab at a referral center in Brazil during the first two years of age. A structured questionnaire was administered in a face-to-face interview with parents or legal guardians. Results: The study included 410 preterm infants (median age = 9 months [0-24 months]). In the sample as a whole, 111 children (27.1%; [95% CI, 22.9-31.5]) had RW. The univariate analysis between the groups with and without RW showed no differences regarding the following variables: sex, ethnicity, maternal level of education, gestational age, birth weight, breastfeeding, number of children in the household, day care center attendance, pets in the household, and smoking caregiver. The prevalence of RW was twice as high among children with bronchopulmonary dysplasia (adjusted OR = 2.08; 95% CI, 1.11-3.89; p = 0.022) and almost five times as high among those with a personal/family history of atopy (adjusted OR = 4.96; 95% CI, 2.62-9.39; p < 0.001) as among those without these conditions. Conclusions: Preterm infants who received prophylaxis with palivizumab but have a personal/family history of atopy or bronchopulmonary dysplasia are more likely to have RW than do those without these conditions.