Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome

• Autor(a) principal: Bosco,Adriane Dal
• Data de Publicação: 2019
• Outros Autores: Schedler,Filipe Boeira, Colares,Josieli Raskopf, Schemitt,Elisângela Gonçalves, Hartmann,Renata Minuzzo, Forgiarini Junior,Luiz Alberto, Dias,Alexandre Simões, Marroni,Norma Possa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Jornal Brasileiro de Pneumologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000300204
• topic: Bile duct; Hepatopulmonary Syndrome; Melatonin; Lung

ABSTRACT Objective: To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL). Methods: Sixteen male Wistar rats, divided into four Sham groups: BDL group, Sham + MEL group and BDL + MEL. The pulmonary and hepatic histology, lipoperoxidation and antioxidant activity of lung tissue, alveolar-arterial O2 difference and lung / body weight ratio (%) were evaluated. Results: When comparing the groups, could be observed an increase of vasodilation and pulmonary fibrosis in the BDL group and the reduction of this in relation to the BDL + MEL group. It was also observed significant changes in the activity of catalase, ApCO2, ApO2 in the LBD group when compared to the other groups. Conclusion: The use of MEL has been shown to be effective in reducing vasodilation, fibrosis levels and oxidative stress as well as gas exchange in an experimental HPS model.