Lack of association between viral load and severity of acute bronchiolitis in infants
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Pneumologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400261 |
Resumo: | ABSTRACT Objective: To investigate the correlation between respiratory syncytial viral load and length of hospitalization in infants with acute wheezing episodes. Methods: This was a two-year, cross-sectional study of infants ≤ 12 months of age with bronchiolitis at the time of admission to a tertiary hospital. For the identification of respiratory viruses, nasopharyngeal secretions were collected. Samples were analyzed (throughout the study period) by direct immunofluorescence and (in the second year of the study) by quantitative real-time PCR. We screened for three human viruses: rhinovirus, respiratory syncytial virus, and metapneumovirus. Results: Of 110 samples evaluated by direct immunofluorescence, 56 (50.9%) were positive for a single virus, and 16 (14.5%) were positive for two or more viruses. Among those 72 samples, the most prevalent virus was respiratory syncytial virus, followed by influenza. Of 56 samples evaluated by quantitative real-time PCR, 24 (42.8%) were positive for a single virus, and 1 (1.7%) was positive for two viruses. Among those 25 samples, the most prevalent virus was again respiratory syncytial virus, followed by human rhinovirus. Coinfection did not influence the length of the hospital stay or other outcome s. In addition, there was no association between respiratory syncytial virus load and the length of hospitalization. Conclusions: Neither coinfection nor respiratory syncytial viral load appears to influence the outcomes of acute bronchiolitis in infants. |
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Lack of association between viral load and severity of acute bronchiolitis in infantsBronchiolitisCoinfectionViral loadHospitalizationRespiratory syncytial virus, humanABSTRACT Objective: To investigate the correlation between respiratory syncytial viral load and length of hospitalization in infants with acute wheezing episodes. Methods: This was a two-year, cross-sectional study of infants ≤ 12 months of age with bronchiolitis at the time of admission to a tertiary hospital. For the identification of respiratory viruses, nasopharyngeal secretions were collected. Samples were analyzed (throughout the study period) by direct immunofluorescence and (in the second year of the study) by quantitative real-time PCR. We screened for three human viruses: rhinovirus, respiratory syncytial virus, and metapneumovirus. Results: Of 110 samples evaluated by direct immunofluorescence, 56 (50.9%) were positive for a single virus, and 16 (14.5%) were positive for two or more viruses. Among those 72 samples, the most prevalent virus was respiratory syncytial virus, followed by influenza. Of 56 samples evaluated by quantitative real-time PCR, 24 (42.8%) were positive for a single virus, and 1 (1.7%) was positive for two viruses. Among those 25 samples, the most prevalent virus was again respiratory syncytial virus, followed by human rhinovirus. Coinfection did not influence the length of the hospital stay or other outcome s. In addition, there was no association between respiratory syncytial virus load and the length of hospitalization. Conclusions: Neither coinfection nor respiratory syncytial viral load appears to influence the outcomes of acute bronchiolitis in infants.Sociedade Brasileira de Pneumologia e Tisiologia2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400261Jornal Brasileiro de Pneumologia v.42 n.4 2016reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/s1806-37562015000000241info:eu-repo/semantics/openAccessSouza,Ana Paula Duarte deLeitão,Lidiane Alves de AzeredoLuisi,FernandaSouza,Rodrigo GodinhoCoutinho,Sandra EugêniaSilva,Jaqueline Ramos daMattiello,RitaPitrez,Paulo Márcio CondessaStein,Renato TetelbomPinto,Leonardo Araújoeng2017-03-10T00:00:00Zoai:scielo:S1806-37132016000400261Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2017-03-10T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false |
dc.title.none.fl_str_mv |
Lack of association between viral load and severity of acute bronchiolitis in infants |
title |
Lack of association between viral load and severity of acute bronchiolitis in infants |
spellingShingle |
Lack of association between viral load and severity of acute bronchiolitis in infants Souza,Ana Paula Duarte de Bronchiolitis Coinfection Viral load Hospitalization Respiratory syncytial virus, human |
title_short |
Lack of association between viral load and severity of acute bronchiolitis in infants |
title_full |
Lack of association between viral load and severity of acute bronchiolitis in infants |
title_fullStr |
Lack of association between viral load and severity of acute bronchiolitis in infants |
title_full_unstemmed |
Lack of association between viral load and severity of acute bronchiolitis in infants |
title_sort |
Lack of association between viral load and severity of acute bronchiolitis in infants |
author |
Souza,Ana Paula Duarte de |
author_facet |
Souza,Ana Paula Duarte de Leitão,Lidiane Alves de Azeredo Luisi,Fernanda Souza,Rodrigo Godinho Coutinho,Sandra Eugênia Silva,Jaqueline Ramos da Mattiello,Rita Pitrez,Paulo Márcio Condessa Stein,Renato Tetelbom Pinto,Leonardo Araújo |
author_role |
author |
author2 |
Leitão,Lidiane Alves de Azeredo Luisi,Fernanda Souza,Rodrigo Godinho Coutinho,Sandra Eugênia Silva,Jaqueline Ramos da Mattiello,Rita Pitrez,Paulo Márcio Condessa Stein,Renato Tetelbom Pinto,Leonardo Araújo |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza,Ana Paula Duarte de Leitão,Lidiane Alves de Azeredo Luisi,Fernanda Souza,Rodrigo Godinho Coutinho,Sandra Eugênia Silva,Jaqueline Ramos da Mattiello,Rita Pitrez,Paulo Márcio Condessa Stein,Renato Tetelbom Pinto,Leonardo Araújo |
dc.subject.por.fl_str_mv |
Bronchiolitis Coinfection Viral load Hospitalization Respiratory syncytial virus, human |
topic |
Bronchiolitis Coinfection Viral load Hospitalization Respiratory syncytial virus, human |
description |
ABSTRACT Objective: To investigate the correlation between respiratory syncytial viral load and length of hospitalization in infants with acute wheezing episodes. Methods: This was a two-year, cross-sectional study of infants ≤ 12 months of age with bronchiolitis at the time of admission to a tertiary hospital. For the identification of respiratory viruses, nasopharyngeal secretions were collected. Samples were analyzed (throughout the study period) by direct immunofluorescence and (in the second year of the study) by quantitative real-time PCR. We screened for three human viruses: rhinovirus, respiratory syncytial virus, and metapneumovirus. Results: Of 110 samples evaluated by direct immunofluorescence, 56 (50.9%) were positive for a single virus, and 16 (14.5%) were positive for two or more viruses. Among those 72 samples, the most prevalent virus was respiratory syncytial virus, followed by influenza. Of 56 samples evaluated by quantitative real-time PCR, 24 (42.8%) were positive for a single virus, and 1 (1.7%) was positive for two viruses. Among those 25 samples, the most prevalent virus was again respiratory syncytial virus, followed by human rhinovirus. Coinfection did not influence the length of the hospital stay or other outcome s. In addition, there was no association between respiratory syncytial virus load and the length of hospitalization. Conclusions: Neither coinfection nor respiratory syncytial viral load appears to influence the outcomes of acute bronchiolitis in infants. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400261 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400261 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1806-37562015000000241 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Pneumologia v.42 n.4 2016 reponame:Jornal Brasileiro de Pneumologia (Online) instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) instacron:SBPT |
instname_str |
Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
instacron_str |
SBPT |
institution |
SBPT |
reponame_str |
Jornal Brasileiro de Pneumologia (Online) |
collection |
Jornal Brasileiro de Pneumologia (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
repository.mail.fl_str_mv |
||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br |
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1750318346442637312 |