Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Pneumologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132017000300208 |
Resumo: | ABSTRACT Objective: To evaluate the effects of exposure to emissions from sugar cane burning on inflammatory mechanisms in tissues of the trachea and lung parenchyma in Wistar rats after different periods of exposure. Methods: This was an experimental open randomized study. The animals were divided into four groups: a control group (CG) underwent standard laboratory conditions, and three experimental groups were exposed to emissions from sugar cane burning over different periods of time, in days-1 (EG1), 7 (EG7), and 21 (EG21). After euthanasia with 200 mg/kg of ketamine/xylazine, fragments of trachea and lung were collected and fixed in 10% formalin. Histological analyses were performed with H&E and picrosirius red staining. Results: No inflammatory infiltrates were found in the tissues of CG rats. The histological examination of tissues of the trachea and lung parenchyma revealed that the inflammatory process was significantly more intense in EG7 than in the CG (p < 0.05 and p < 0.01, respectively). In comparison with the CG and EG1, angiogenesis in the lung parenchyma and collagen deposition in tracheal tissues were significantly greater only in EG21 (p < 0.001 and p < 0.01, respectively). Conclusions: In this sample, emissions from sugar cane burning induced acute focal and diffuse inflammation in the lamina propria of tracheal tissues, with no loss of ciliated epithelial tissue. In the lung parenchyma of the animals in the experimental groups, there was interstitial and alveolar edema, together with polymorphonuclear cell infiltrates. |
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Jornal Brasileiro de Pneumologia (Online) |
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Effects of emissions from sugar cane burning on the trachea and lungs of Wistar ratsSaccharumSmokeInflammationRespiratory systemABSTRACT Objective: To evaluate the effects of exposure to emissions from sugar cane burning on inflammatory mechanisms in tissues of the trachea and lung parenchyma in Wistar rats after different periods of exposure. Methods: This was an experimental open randomized study. The animals were divided into four groups: a control group (CG) underwent standard laboratory conditions, and three experimental groups were exposed to emissions from sugar cane burning over different periods of time, in days-1 (EG1), 7 (EG7), and 21 (EG21). After euthanasia with 200 mg/kg of ketamine/xylazine, fragments of trachea and lung were collected and fixed in 10% formalin. Histological analyses were performed with H&E and picrosirius red staining. Results: No inflammatory infiltrates were found in the tissues of CG rats. The histological examination of tissues of the trachea and lung parenchyma revealed that the inflammatory process was significantly more intense in EG7 than in the CG (p < 0.05 and p < 0.01, respectively). In comparison with the CG and EG1, angiogenesis in the lung parenchyma and collagen deposition in tracheal tissues were significantly greater only in EG21 (p < 0.001 and p < 0.01, respectively). Conclusions: In this sample, emissions from sugar cane burning induced acute focal and diffuse inflammation in the lamina propria of tracheal tissues, with no loss of ciliated epithelial tissue. In the lung parenchyma of the animals in the experimental groups, there was interstitial and alveolar edema, together with polymorphonuclear cell infiltrates.Sociedade Brasileira de Pneumologia e Tisiologia2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132017000300208Jornal Brasileiro de Pneumologia v.43 n.3 2017reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/s1806-37562016000000144info:eu-repo/semantics/openAccessMatos,Verena Sampaio BarbosaGomes,Felipe da SilvaOliveira,Tarcio MacenaSchulz,Renata da SilvaRibeiro,Lídia Cristina VillelaGonzales,Astria Dias FerrãoLima,Januário MourãoGuerreiro,Marcos Lázaro da Silvaeng2017-07-13T00:00:00Zoai:scielo:S1806-37132017000300208Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2017-07-13T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false |
dc.title.none.fl_str_mv |
Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats |
title |
Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats |
spellingShingle |
Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats Matos,Verena Sampaio Barbosa Saccharum Smoke Inflammation Respiratory system |
title_short |
Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats |
title_full |
Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats |
title_fullStr |
Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats |
title_full_unstemmed |
Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats |
title_sort |
Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats |
author |
Matos,Verena Sampaio Barbosa |
author_facet |
Matos,Verena Sampaio Barbosa Gomes,Felipe da Silva Oliveira,Tarcio Macena Schulz,Renata da Silva Ribeiro,Lídia Cristina Villela Gonzales,Astria Dias Ferrão Lima,Januário Mourão Guerreiro,Marcos Lázaro da Silva |
author_role |
author |
author2 |
Gomes,Felipe da Silva Oliveira,Tarcio Macena Schulz,Renata da Silva Ribeiro,Lídia Cristina Villela Gonzales,Astria Dias Ferrão Lima,Januário Mourão Guerreiro,Marcos Lázaro da Silva |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Matos,Verena Sampaio Barbosa Gomes,Felipe da Silva Oliveira,Tarcio Macena Schulz,Renata da Silva Ribeiro,Lídia Cristina Villela Gonzales,Astria Dias Ferrão Lima,Januário Mourão Guerreiro,Marcos Lázaro da Silva |
dc.subject.por.fl_str_mv |
Saccharum Smoke Inflammation Respiratory system |
topic |
Saccharum Smoke Inflammation Respiratory system |
description |
ABSTRACT Objective: To evaluate the effects of exposure to emissions from sugar cane burning on inflammatory mechanisms in tissues of the trachea and lung parenchyma in Wistar rats after different periods of exposure. Methods: This was an experimental open randomized study. The animals were divided into four groups: a control group (CG) underwent standard laboratory conditions, and three experimental groups were exposed to emissions from sugar cane burning over different periods of time, in days-1 (EG1), 7 (EG7), and 21 (EG21). After euthanasia with 200 mg/kg of ketamine/xylazine, fragments of trachea and lung were collected and fixed in 10% formalin. Histological analyses were performed with H&E and picrosirius red staining. Results: No inflammatory infiltrates were found in the tissues of CG rats. The histological examination of tissues of the trachea and lung parenchyma revealed that the inflammatory process was significantly more intense in EG7 than in the CG (p < 0.05 and p < 0.01, respectively). In comparison with the CG and EG1, angiogenesis in the lung parenchyma and collagen deposition in tracheal tissues were significantly greater only in EG21 (p < 0.001 and p < 0.01, respectively). Conclusions: In this sample, emissions from sugar cane burning induced acute focal and diffuse inflammation in the lamina propria of tracheal tissues, with no loss of ciliated epithelial tissue. In the lung parenchyma of the animals in the experimental groups, there was interstitial and alveolar edema, together with polymorphonuclear cell infiltrates. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132017000300208 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132017000300208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1806-37562016000000144 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Pneumologia v.43 n.3 2017 reponame:Jornal Brasileiro de Pneumologia (Online) instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) instacron:SBPT |
instname_str |
Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
instacron_str |
SBPT |
institution |
SBPT |
reponame_str |
Jornal Brasileiro de Pneumologia (Online) |
collection |
Jornal Brasileiro de Pneumologia (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
repository.mail.fl_str_mv |
||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br |
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1750318346819076096 |