Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Pneumologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400241 |
Resumo: | ABSTRACT Objective: To determine whether COPD severity correlates with sputum cell counts, atopy, and asthma. Methods: This was a cross-sectional study involving 37 patients with COPD and 22 healthy subjects with normal lung function (controls). Sputum cell counts were determined by microscopy after centrifugation of samples. Skin prick tests were performed, and serum cytokines were determined by ELISA. Results: Patients were stratified by bronchodilator response: a non-reversible airflow limitation (nonRAL) group comprised 24 patients showing no significant post-bronchodilator change in FEV1; and a partially reversible airflow limitation (partialRAL) group comprised 13 patients showing FEV1 reversibility (post-bronchodilator FEV1 increase ≥ 12%). The proportion of eosinophils in sputum was higher in the partialRAL group than in the nonRAL group (p < 0.01), and there was an inverse correlation between the proportion of eosinophils and FEV1 (p < 0.05). However, none of the patients had a history of asthma and skin prick test results did not differ between the two groups. In the patient sputum samples, neutrophils predominated. Serum levels of TNF, IL-6, IL-8, and RANTES (CCL5) were higher in patients than in controls (p < 0.001) but did not differ between the two patient groups. Conclusions: COPD patients with partial FEV1 reversibility appear to have higher sputum eosinophil counts and greater airway hyperresponsiveness than do those with no FEV1 reversibility. However, we found that COPD severity did not correlate with atopy or with the cytokine profile. |
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Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibilityPulmonary disease, chronic obstructiveCytokinesChemokinesEosinophilsSputum/cytologyForced expiratory volumeABSTRACT Objective: To determine whether COPD severity correlates with sputum cell counts, atopy, and asthma. Methods: This was a cross-sectional study involving 37 patients with COPD and 22 healthy subjects with normal lung function (controls). Sputum cell counts were determined by microscopy after centrifugation of samples. Skin prick tests were performed, and serum cytokines were determined by ELISA. Results: Patients were stratified by bronchodilator response: a non-reversible airflow limitation (nonRAL) group comprised 24 patients showing no significant post-bronchodilator change in FEV1; and a partially reversible airflow limitation (partialRAL) group comprised 13 patients showing FEV1 reversibility (post-bronchodilator FEV1 increase ≥ 12%). The proportion of eosinophils in sputum was higher in the partialRAL group than in the nonRAL group (p < 0.01), and there was an inverse correlation between the proportion of eosinophils and FEV1 (p < 0.05). However, none of the patients had a history of asthma and skin prick test results did not differ between the two groups. In the patient sputum samples, neutrophils predominated. Serum levels of TNF, IL-6, IL-8, and RANTES (CCL5) were higher in patients than in controls (p < 0.001) but did not differ between the two patient groups. Conclusions: COPD patients with partial FEV1 reversibility appear to have higher sputum eosinophil counts and greater airway hyperresponsiveness than do those with no FEV1 reversibility. However, we found that COPD severity did not correlate with atopy or with the cytokine profile.Sociedade Brasileira de Pneumologia e Tisiologia2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400241Jornal Brasileiro de Pneumologia v.42 n.4 2016reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/s1806-37562015000000122info:eu-repo/semantics/openAccessQueiroz,Cleriston FariasLemos,Antonio Carlos MoreiraBastos,Maria de Lourdes SantanaNeves,Margarida Célia Lima CostaCamelier,Aquiles AssunçãoCarvalho,Natália BarbosaCarvalho,Edgar Marcelino deeng2017-03-10T00:00:00Zoai:scielo:S1806-37132016000400241Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2017-03-10T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false |
dc.title.none.fl_str_mv |
Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility |
title |
Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility |
spellingShingle |
Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility Queiroz,Cleriston Farias Pulmonary disease, chronic obstructive Cytokines Chemokines Eosinophils Sputum/cytology Forced expiratory volume |
title_short |
Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility |
title_full |
Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility |
title_fullStr |
Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility |
title_full_unstemmed |
Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility |
title_sort |
Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility |
author |
Queiroz,Cleriston Farias |
author_facet |
Queiroz,Cleriston Farias Lemos,Antonio Carlos Moreira Bastos,Maria de Lourdes Santana Neves,Margarida Célia Lima Costa Camelier,Aquiles Assunção Carvalho,Natália Barbosa Carvalho,Edgar Marcelino de |
author_role |
author |
author2 |
Lemos,Antonio Carlos Moreira Bastos,Maria de Lourdes Santana Neves,Margarida Célia Lima Costa Camelier,Aquiles Assunção Carvalho,Natália Barbosa Carvalho,Edgar Marcelino de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Queiroz,Cleriston Farias Lemos,Antonio Carlos Moreira Bastos,Maria de Lourdes Santana Neves,Margarida Célia Lima Costa Camelier,Aquiles Assunção Carvalho,Natália Barbosa Carvalho,Edgar Marcelino de |
dc.subject.por.fl_str_mv |
Pulmonary disease, chronic obstructive Cytokines Chemokines Eosinophils Sputum/cytology Forced expiratory volume |
topic |
Pulmonary disease, chronic obstructive Cytokines Chemokines Eosinophils Sputum/cytology Forced expiratory volume |
description |
ABSTRACT Objective: To determine whether COPD severity correlates with sputum cell counts, atopy, and asthma. Methods: This was a cross-sectional study involving 37 patients with COPD and 22 healthy subjects with normal lung function (controls). Sputum cell counts were determined by microscopy after centrifugation of samples. Skin prick tests were performed, and serum cytokines were determined by ELISA. Results: Patients were stratified by bronchodilator response: a non-reversible airflow limitation (nonRAL) group comprised 24 patients showing no significant post-bronchodilator change in FEV1; and a partially reversible airflow limitation (partialRAL) group comprised 13 patients showing FEV1 reversibility (post-bronchodilator FEV1 increase ≥ 12%). The proportion of eosinophils in sputum was higher in the partialRAL group than in the nonRAL group (p < 0.01), and there was an inverse correlation between the proportion of eosinophils and FEV1 (p < 0.05). However, none of the patients had a history of asthma and skin prick test results did not differ between the two groups. In the patient sputum samples, neutrophils predominated. Serum levels of TNF, IL-6, IL-8, and RANTES (CCL5) were higher in patients than in controls (p < 0.001) but did not differ between the two patient groups. Conclusions: COPD patients with partial FEV1 reversibility appear to have higher sputum eosinophil counts and greater airway hyperresponsiveness than do those with no FEV1 reversibility. However, we found that COPD severity did not correlate with atopy or with the cytokine profile. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400241 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400241 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1806-37562015000000122 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Pneumologia v.42 n.4 2016 reponame:Jornal Brasileiro de Pneumologia (Online) instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) instacron:SBPT |
instname_str |
Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
instacron_str |
SBPT |
institution |
SBPT |
reponame_str |
Jornal Brasileiro de Pneumologia (Online) |
collection |
Jornal Brasileiro de Pneumologia (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
repository.mail.fl_str_mv |
||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br |
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1750318346436345856 |