Reperfusion in acute pulmonary thromboembolism

• Autor(a) principal: Fernandes,Caio Julio Cesar dos Santos
• Data de Publicação: 2018
• Outros Autores: Jardim,Carlos Vianna Poyares, Alves Jr,José Leonidas, Oleas,Francisca Alexandra Gavilanes, Morinaga,Luciana Tamie Kato, Souza,Rogério de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Jornal Brasileiro de Pneumologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000300237
• topic: Embolism; Shock; Hypotension; Thrombolytic therapy; Reperfusion; Hemorrhage

ABSTRACT Acute pulmonary thromboembolism (APTE) is a highly prevalent condition (104-183 cases per 100,000 person-years) and is potentially fatal. Approximately 20% of patients with APTE are hypotensive, being considered at high risk of death. In such patients, immediate lung reperfusion is necessary in order to reduce right ventricular afterload and to restore hemodynamic stability. To reduce pulmonary vascular resistance in APTE and, consequently, to improve right ventricular function, lung reperfusion strategies have been developed over time and widely studied in recent years. In this review, we focus on advances in the indication and use of systemic thrombolytic agents, as well as lung reperfusion via endovascular and classical surgical approaches, in APTE.