A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones

Detalhes bibliográficos
Autor(a) principal: Cardoso,Mariana F. C.
Data de Publicação: 2013
Outros Autores: Silva,Illana M. C. B. da, Santos Júnior,Helvécio M. dos, Rocha,David R., Araújo,Ana Jérsia, Pessoa,Claudia, Moraes,Manoel O. de, Lotufo,Letícia V. C., Silva,Fernando de C. da, Santos,Wilson C., Ferreira,Vitor F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000100003
Resumo: Several studies have demonstrated the cytotoxic potential of nor-β-lapachone derivative against cancer cells. Considering nor-β-lapachone as an important prototype, a set of new 3-substituted nor-β-lapachones was synthesized by a new synthetic route that involves the use of synthetic intermediate generated for coupling with several nucleophiles containing the carbohydrate and 2H-pyrazole substituent moieties. All the compounds were screened against four tumor cell lines. Two of the compounds showed moderate cytotoxicity, while the other compounds strongly inhibit all tested cancer cell lines.
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spelling A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachonesnaphthoquinoneheterocyclecytotoxicitycarbohydrateSeveral studies have demonstrated the cytotoxic potential of nor-β-lapachone derivative against cancer cells. Considering nor-β-lapachone as an important prototype, a set of new 3-substituted nor-β-lapachones was synthesized by a new synthetic route that involves the use of synthetic intermediate generated for coupling with several nucleophiles containing the carbohydrate and 2H-pyrazole substituent moieties. All the compounds were screened against four tumor cell lines. Two of the compounds showed moderate cytotoxicity, while the other compounds strongly inhibit all tested cancer cell lines.Sociedade Brasileira de Química2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000100003Journal of the Brazilian Chemical Society v.24 n.1 2013reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532013000100003info:eu-repo/semantics/openAccessCardoso,Mariana F. C.Silva,Illana M. C. B. daSantos Júnior,Helvécio M. dosRocha,David R.Araújo,Ana JérsiaPessoa,ClaudiaMoraes,Manoel O. deLotufo,Letícia V. C.Silva,Fernando de C. daSantos,Wilson C.Ferreira,Vitor F.eng2013-02-28T00:00:00Zoai:scielo:S0103-50532013000100003Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2013-02-28T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
title A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
spellingShingle A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
Cardoso,Mariana F. C.
naphthoquinone
heterocycle
cytotoxicity
carbohydrate
title_short A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
title_full A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
title_fullStr A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
title_full_unstemmed A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
title_sort A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
author Cardoso,Mariana F. C.
author_facet Cardoso,Mariana F. C.
Silva,Illana M. C. B. da
Santos Júnior,Helvécio M. dos
Rocha,David R.
Araújo,Ana Jérsia
Pessoa,Claudia
Moraes,Manoel O. de
Lotufo,Letícia V. C.
Silva,Fernando de C. da
Santos,Wilson C.
Ferreira,Vitor F.
author_role author
author2 Silva,Illana M. C. B. da
Santos Júnior,Helvécio M. dos
Rocha,David R.
Araújo,Ana Jérsia
Pessoa,Claudia
Moraes,Manoel O. de
Lotufo,Letícia V. C.
Silva,Fernando de C. da
Santos,Wilson C.
Ferreira,Vitor F.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso,Mariana F. C.
Silva,Illana M. C. B. da
Santos Júnior,Helvécio M. dos
Rocha,David R.
Araújo,Ana Jérsia
Pessoa,Claudia
Moraes,Manoel O. de
Lotufo,Letícia V. C.
Silva,Fernando de C. da
Santos,Wilson C.
Ferreira,Vitor F.
dc.subject.por.fl_str_mv naphthoquinone
heterocycle
cytotoxicity
carbohydrate
topic naphthoquinone
heterocycle
cytotoxicity
carbohydrate
description Several studies have demonstrated the cytotoxic potential of nor-β-lapachone derivative against cancer cells. Considering nor-β-lapachone as an important prototype, a set of new 3-substituted nor-β-lapachones was synthesized by a new synthetic route that involves the use of synthetic intermediate generated for coupling with several nucleophiles containing the carbohydrate and 2H-pyrazole substituent moieties. All the compounds were screened against four tumor cell lines. Two of the compounds showed moderate cytotoxicity, while the other compounds strongly inhibit all tested cancer cell lines.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000100003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532013000100003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.24 n.1 2013
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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