Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives

Detalhes bibliográficos
Autor(a) principal: Reis,Roberta C. N.
Data de Publicação: 2008
Outros Autores: Oda,Simone C., Almeida,Mauro V. De, Lourenço,Maria C. S., Vicente,Felipe R. C., Barbosa,Nadia R., Trevizani,Rafael, Santos,Priscila L. C., Le Hyaric,Mireille
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000600003
Resumo: N-monoalkylated diamines were synthesised and treated with D-ribonolactone or D-gluconolactone. The resulting aldonamides were evaluated for their antimicrobial activity against S. aureus, E. coli, M. tuberculosis and C. albicans. Two hydrazides were also prepared from ribonohydrazide and their biological activity was compared to their amide analogues. All the ribono-derivatives displayed moderated antitubercular activity, and some of them were also active against S. aureus.
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spelling Synthesis and antimicrobial activity of amphiphilic carbohydrate derivativesantimicrobialM. tuberculosisamphiphilicaldonamideN-monoalkylated diamines were synthesised and treated with D-ribonolactone or D-gluconolactone. The resulting aldonamides were evaluated for their antimicrobial activity against S. aureus, E. coli, M. tuberculosis and C. albicans. Two hydrazides were also prepared from ribonohydrazide and their biological activity was compared to their amide analogues. All the ribono-derivatives displayed moderated antitubercular activity, and some of them were also active against S. aureus.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000600003Journal of the Brazilian Chemical Society v.19 n.6 2008reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532008000600003info:eu-repo/semantics/openAccessReis,Roberta C. N.Oda,Simone C.Almeida,Mauro V. DeLourenço,Maria C. S.Vicente,Felipe R. C.Barbosa,Nadia R.Trevizani,RafaelSantos,Priscila L. C.Le Hyaric,Mireilleeng2008-09-12T00:00:00Zoai:scielo:S0103-50532008000600003Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2008-09-12T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
title Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
spellingShingle Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
Reis,Roberta C. N.
antimicrobial
M. tuberculosis
amphiphilic
aldonamide
title_short Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
title_full Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
title_fullStr Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
title_full_unstemmed Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
title_sort Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
author Reis,Roberta C. N.
author_facet Reis,Roberta C. N.
Oda,Simone C.
Almeida,Mauro V. De
Lourenço,Maria C. S.
Vicente,Felipe R. C.
Barbosa,Nadia R.
Trevizani,Rafael
Santos,Priscila L. C.
Le Hyaric,Mireille
author_role author
author2 Oda,Simone C.
Almeida,Mauro V. De
Lourenço,Maria C. S.
Vicente,Felipe R. C.
Barbosa,Nadia R.
Trevizani,Rafael
Santos,Priscila L. C.
Le Hyaric,Mireille
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis,Roberta C. N.
Oda,Simone C.
Almeida,Mauro V. De
Lourenço,Maria C. S.
Vicente,Felipe R. C.
Barbosa,Nadia R.
Trevizani,Rafael
Santos,Priscila L. C.
Le Hyaric,Mireille
dc.subject.por.fl_str_mv antimicrobial
M. tuberculosis
amphiphilic
aldonamide
topic antimicrobial
M. tuberculosis
amphiphilic
aldonamide
description N-monoalkylated diamines were synthesised and treated with D-ribonolactone or D-gluconolactone. The resulting aldonamides were evaluated for their antimicrobial activity against S. aureus, E. coli, M. tuberculosis and C. albicans. Two hydrazides were also prepared from ribonohydrazide and their biological activity was compared to their amide analogues. All the ribono-derivatives displayed moderated antitubercular activity, and some of them were also active against S. aureus.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000600003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000600003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532008000600003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.19 n.6 2008
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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