Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA

Detalhes bibliográficos
Autor(a) principal: Baeta,Jefferson V. P. B.
Data de Publicação: 2021
Outros Autores: Andrade,Ulisses M. S., Oliveira,Rayane M., Oliveira,Leandro, Santos,Anésia A., Diaz-Muñoz,Gaspar, Rocha,Márcio S., Diaz,Marisa A. N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000701491
Resumo: In this study, we assessed the cytotoxic effect of 1,3-diphenyl-2-allyl-1,3-propanedione (DPAP) on B16F10 and Tm5 melanoma cells and investigated its interaction with DNA (deoxyribonucleic acid) using optical tweezers. The compound showed to be effective against B16F10 cells with selectivity index (SI) of 7.92 and interaction to the outer surface of the double helix, probably at the minor groove of DNA. This likely induced a bending deformation of the polymer chain, decreasing persistence length, and indicated that each DPAP molecule occupies a single base pair upon binding to the double helix.
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spelling Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNADPAPoptical tweezersDNAB16F10 cellsTm5 cellsdacarbazineIn this study, we assessed the cytotoxic effect of 1,3-diphenyl-2-allyl-1,3-propanedione (DPAP) on B16F10 and Tm5 melanoma cells and investigated its interaction with DNA (deoxyribonucleic acid) using optical tweezers. The compound showed to be effective against B16F10 cells with selectivity index (SI) of 7.92 and interaction to the outer surface of the double helix, probably at the minor groove of DNA. This likely induced a bending deformation of the polymer chain, decreasing persistence length, and indicated that each DPAP molecule occupies a single base pair upon binding to the double helix.Sociedade Brasileira de Química2021-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000701491Journal of the Brazilian Chemical Society v.32 n.7 2021reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20210048info:eu-repo/semantics/openAccessBaeta,Jefferson V. P. B.Andrade,Ulisses M. S.Oliveira,Rayane M.Oliveira,LeandroSantos,Anésia A.Diaz-Muñoz,GasparRocha,Márcio S.Diaz,Marisa A. N.eng2021-06-30T00:00:00Zoai:scielo:S0103-50532021000701491Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2021-06-30T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
title Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
spellingShingle Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
Baeta,Jefferson V. P. B.
DPAP
optical tweezers
DNA
B16F10 cells
Tm5 cells
dacarbazine
title_short Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
title_full Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
title_fullStr Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
title_full_unstemmed Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
title_sort Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
author Baeta,Jefferson V. P. B.
author_facet Baeta,Jefferson V. P. B.
Andrade,Ulisses M. S.
Oliveira,Rayane M.
Oliveira,Leandro
Santos,Anésia A.
Diaz-Muñoz,Gaspar
Rocha,Márcio S.
Diaz,Marisa A. N.
author_role author
author2 Andrade,Ulisses M. S.
Oliveira,Rayane M.
Oliveira,Leandro
Santos,Anésia A.
Diaz-Muñoz,Gaspar
Rocha,Márcio S.
Diaz,Marisa A. N.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Baeta,Jefferson V. P. B.
Andrade,Ulisses M. S.
Oliveira,Rayane M.
Oliveira,Leandro
Santos,Anésia A.
Diaz-Muñoz,Gaspar
Rocha,Márcio S.
Diaz,Marisa A. N.
dc.subject.por.fl_str_mv DPAP
optical tweezers
DNA
B16F10 cells
Tm5 cells
dacarbazine
topic DPAP
optical tweezers
DNA
B16F10 cells
Tm5 cells
dacarbazine
description In this study, we assessed the cytotoxic effect of 1,3-diphenyl-2-allyl-1,3-propanedione (DPAP) on B16F10 and Tm5 melanoma cells and investigated its interaction with DNA (deoxyribonucleic acid) using optical tweezers. The compound showed to be effective against B16F10 cells with selectivity index (SI) of 7.92 and interaction to the outer surface of the double helix, probably at the minor groove of DNA. This likely induced a bending deformation of the polymer chain, decreasing persistence length, and indicated that each DPAP molecule occupies a single base pair upon binding to the double helix.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000701491
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000701491
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0103-5053.20210048
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.32 n.7 2021
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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