A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000800020 |
Resumo: | A chemically modified electrode was constructed based on a multi-walled carbon nanotube-modified glassy carbon electrode (MWCNTs/GCE). It was demonstrated that this sensor can be used for the simultaneous determination of the pharmaceutically important compounds paracetamol (PAR) and tramadol (TRA). The measurements were carried out by the application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. Application of the DPV method demonstrated that in phosphate buffer (pH 7.5) there was a linear relationship between the oxidation peak current and the concentration of PAR over the range 0.5 µmol L-1 to 210 µmol L-1. A similar linear correlation between oxidation peak current and concentration was observed for TRA over the range of 2 µmol L-1 to 300 µmol L-1. Under optimal conditions the modified electrode exhibited high sensitivity, selectivity and stability for both PAR and TRA determination, making it a suitable sensor for the simultaneous submicromolar detection of PAR and TRA in solutions. The analytical performance of this sensor has been evaluated for detection of PAR and TRA in human serum, human urine and some pharmaceutical preparations with satisfactory results. |
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A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluidsparacetamoltramadolcarbon nanotubemodified glassy carbonelectrochemical sensorA chemically modified electrode was constructed based on a multi-walled carbon nanotube-modified glassy carbon electrode (MWCNTs/GCE). It was demonstrated that this sensor can be used for the simultaneous determination of the pharmaceutically important compounds paracetamol (PAR) and tramadol (TRA). The measurements were carried out by the application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. Application of the DPV method demonstrated that in phosphate buffer (pH 7.5) there was a linear relationship between the oxidation peak current and the concentration of PAR over the range 0.5 µmol L-1 to 210 µmol L-1. A similar linear correlation between oxidation peak current and concentration was observed for TRA over the range of 2 µmol L-1 to 300 µmol L-1. Under optimal conditions the modified electrode exhibited high sensitivity, selectivity and stability for both PAR and TRA determination, making it a suitable sensor for the simultaneous submicromolar detection of PAR and TRA in solutions. The analytical performance of this sensor has been evaluated for detection of PAR and TRA in human serum, human urine and some pharmaceutical preparations with satisfactory results.Sociedade Brasileira de Química2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000800020Journal of the Brazilian Chemical Society v.22 n.8 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011000800020info:eu-repo/semantics/openAccessBabaei,AliTaheri,Ali RezaAfrasiabi,Mohammadeng2011-08-04T00:00:00Zoai:scielo:S0103-50532011000800020Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-08-04T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids |
title |
A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids |
spellingShingle |
A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids Babaei,Ali paracetamol tramadol carbon nanotube modified glassy carbon electrochemical sensor |
title_short |
A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids |
title_full |
A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids |
title_fullStr |
A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids |
title_full_unstemmed |
A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids |
title_sort |
A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids |
author |
Babaei,Ali |
author_facet |
Babaei,Ali Taheri,Ali Reza Afrasiabi,Mohammad |
author_role |
author |
author2 |
Taheri,Ali Reza Afrasiabi,Mohammad |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Babaei,Ali Taheri,Ali Reza Afrasiabi,Mohammad |
dc.subject.por.fl_str_mv |
paracetamol tramadol carbon nanotube modified glassy carbon electrochemical sensor |
topic |
paracetamol tramadol carbon nanotube modified glassy carbon electrochemical sensor |
description |
A chemically modified electrode was constructed based on a multi-walled carbon nanotube-modified glassy carbon electrode (MWCNTs/GCE). It was demonstrated that this sensor can be used for the simultaneous determination of the pharmaceutically important compounds paracetamol (PAR) and tramadol (TRA). The measurements were carried out by the application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. Application of the DPV method demonstrated that in phosphate buffer (pH 7.5) there was a linear relationship between the oxidation peak current and the concentration of PAR over the range 0.5 µmol L-1 to 210 µmol L-1. A similar linear correlation between oxidation peak current and concentration was observed for TRA over the range of 2 µmol L-1 to 300 µmol L-1. Under optimal conditions the modified electrode exhibited high sensitivity, selectivity and stability for both PAR and TRA determination, making it a suitable sensor for the simultaneous submicromolar detection of PAR and TRA in solutions. The analytical performance of this sensor has been evaluated for detection of PAR and TRA in human serum, human urine and some pharmaceutical preparations with satisfactory results. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000800020 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000800020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532011000800020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.22 n.8 2011 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318172377972736 |