Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts

Detalhes bibliográficos
Autor(a) principal: Junior,Claudio G. L.
Data de Publicação: 2011
Outros Autores: Silva,Fábio P. L., Oliveira,Ramon G. de, Subrinho,Fernanda L., Andrade,Natália G. de, Vasconcellos,Mário L. A. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011001100028
Resumo: It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 ºC or conventional protocol at 0 ºC to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromophenyl)methyl acrylate formation is reversible at 120 ºC.
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spelling Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adductsmicrowave-promoted reactionsMorita-Baylis-Hillman reactionthermodynamic controltemperature effectantiparasitic compoundsIt is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 ºC or conventional protocol at 0 ºC to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromophenyl)methyl acrylate formation is reversible at 120 ºC.Sociedade Brasileira de Química2011-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011001100028Journal of the Brazilian Chemical Society v.22 n.11 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011001100028info:eu-repo/semantics/openAccessJunior,Claudio G. L.Silva,Fábio P. L.Oliveira,Ramon G. deSubrinho,Fernanda L.Andrade,Natália G. deVasconcellos,Mário L. A. A.eng2011-11-04T00:00:00Zoai:scielo:S0103-50532011001100028Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-11-04T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts
title Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts
spellingShingle Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts
Junior,Claudio G. L.
microwave-promoted reactions
Morita-Baylis-Hillman reaction
thermodynamic control
temperature effect
antiparasitic compounds
title_short Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts
title_full Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts
title_fullStr Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts
title_full_unstemmed Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts
title_sort Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts
author Junior,Claudio G. L.
author_facet Junior,Claudio G. L.
Silva,Fábio P. L.
Oliveira,Ramon G. de
Subrinho,Fernanda L.
Andrade,Natália G. de
Vasconcellos,Mário L. A. A.
author_role author
author2 Silva,Fábio P. L.
Oliveira,Ramon G. de
Subrinho,Fernanda L.
Andrade,Natália G. de
Vasconcellos,Mário L. A. A.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Junior,Claudio G. L.
Silva,Fábio P. L.
Oliveira,Ramon G. de
Subrinho,Fernanda L.
Andrade,Natália G. de
Vasconcellos,Mário L. A. A.
dc.subject.por.fl_str_mv microwave-promoted reactions
Morita-Baylis-Hillman reaction
thermodynamic control
temperature effect
antiparasitic compounds
topic microwave-promoted reactions
Morita-Baylis-Hillman reaction
thermodynamic control
temperature effect
antiparasitic compounds
description It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 ºC or conventional protocol at 0 ºC to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromophenyl)methyl acrylate formation is reversible at 120 ºC.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011001100028
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011001100028
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532011001100028
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.22 n.11 2011
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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