Theoretical and Experimental Investigations on Inclusion Complex β-Cyclodextrin and Sulcatone: A Cardiovascular Activity Evaluation

• Autor(a) principal: Silva,Ivan S.
• Data de Publicação: 2020
• Outros Autores: Feitosa,Eduardo L., Santos,Márcio E. P., Silva,Raiane M., Rocha,Márcio S., Silva,Francisco I. da, Lima,Francisco C. A., Costa,Ana Maria S., Alves,Péricles B., Sousa,Samuel A. A. de, Oliveira,Aldeídia P., Lima,Sidney G. de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000501064
• topic: sulcatone; β-cyclodextrin; hypotension; vasorelaxant activity; computational methods

In this paper, we have applied state-of-the-art technologies and new investigations were developed focusing on obtaining simple and inexpensive molecules for treating cardiovascular diseases, as they are considered the leading cause of death in the world. For the first time, the inclusion complex of sulcatone (SU) and β-cyclodextrin (β-CD) was achieved (using a spray drier) and characterized making use of spectroscopic, thermal and computational methods. In addition, the system was evaluated regarding its vasorelaxant properties. Evidence of the inclusion complex formation was provided using different techniques, such as X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), and 1H nuclear magnetic resonance (NMR) spectroscopies and then deduced by pharmacological experiments, which showed significant changes in relation to the initial material.