Coprecipitation of safrole oxide with poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in supercritical carbon dioxide

• Autor(a) principal: Tenório-Neto,Ernandes T.
• Data de Publicação: 2013
• Outros Autores: Silva,Expedito L., Cellet,Thelma S. Pacheco, Silva,Elisangela P., Franceschi,Elton, C. Filho,Lúcio, Rubira,Adley F., Kunita,Marcos H.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000200021
• topic: SEDS; coprecipitation; safrole oxide; PHBV; factorial design

In recent years, 5-(oxiran-2-ylmethyl)-1,3-benzodioxole or safrole oxide (SO) has been widely studied due to its concentration dependent properties, such as cellular apoptosis inducing activity and cell transdifferentiation. Coprecipitation of SO with a biodegradable and biocompatible polymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), were performed using solution enhanced dispersion by supercritical fluids technique (SEDS). A 2(4-1) factorial design was carried out to investigate the effect of processing parameters (pressure, solution flow, anti-solvent flow and concentrations of PHBV and SO) on the process efficiency and microparticle morphology. Both fibrous and spherical shapes were observed for coprecipitated SO/PHBV, which were dependent on the experimental-processing conditions. Controlled release mechanisms of SO to spherical materials were different from fibrous materials. Thermal analysis showed a decrease in the temperature of maximum weight loss rate (Tmax) of PHBV, attributed to the presence of SO and sample morphology.