A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

• Main Author: Santini,Alberto O.
• Publication Date: 2006
• Other Authors: Oliveira,José E. de, Pezza,Helena R., Pezza,Leonardo
• Format: Article
• Language: eng
• Source: Journal of the Brazilian Chemical Society (Online)
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000400022
• topic: naproxenate-sensitive electrode; potentiometry; pharmaceutical formulations

The characteristics, performance, and application of an electrode, namely, Pt|Hg|Hg2(NAP)2|Graphite, where NAP stands for naproxenate ion, are described. This electrode responds to NAP with sensivity of (58.1± 0.9) mV decade-1 over the range 5.0 x 10-5 - 1.0 x 10-2 mol L-1 at pH 6.0-9.0 and a detection limit of 3.9 x 10-5 mol L-1. The electrode is easily constructed at a relatively low cost with fast response time (within 10-35 s) and can be used for a period of 6 months without any considerable divergence in potentials. The proposed sensor displayed good selectivity for naproxen in the presence of several substances, especially concerning carboxylate and inorganic anions. It was used for the direct assay of naproxen in commercial tablets by means of the standard additions method. The analytical results obtained by using this electrode are in good agreement with those given by the United States Pharmacopeia procedure.