Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity

Detalhes bibliográficos
Autor(a) principal: Moreira,Wagner A. dos Santos
Data de Publicação: 2009
Outros Autores: Lima,Maria da Paz, Ferreira,Antonio Gilberto, Ferreira,Izabel C. Piloto, Nakamura,Celso V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000600014
Resumo: Phytochemical investigation from roots of Spathelia excelsa yielded the chromones 10(2,3-epoxy-3-methylbutanyl) spatheliachromen and 10(2,3-dihydroxy-3-methylbutanyl) methoxyspatheliacromen (5-methoxyspatheliabischromen); limonoid deacetylspathelin and protolimonoid C-21-epimers 3β-angeloyloxy-7α,24,25-trihydroxy-21,23-oxide-14,18-cycloapotirucall-21-hemiacetal; the alkaloids 7,8-dimethoxyflindersin, casimiroin and N-methyl-4,7,8-trimethoxyquinolin-2(1H)-one, besides a mixture of β-sitosterol and stigmasterol. Assays on promastigote forms of Leishmania braziliensis, deacetylspathelin showed moderate activity; and on epimastigote forms of Trypanossoma cruzi, 10(2,3-epoxy-3-methylbutanyl)spatheliachromen exhibited strong activity (IC50 = 11 µg mL-1).
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spelling Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activityRutaceaeSpatheliaTrypanossoma cruziLeishmania braziliensisPhytochemical investigation from roots of Spathelia excelsa yielded the chromones 10(2,3-epoxy-3-methylbutanyl) spatheliachromen and 10(2,3-dihydroxy-3-methylbutanyl) methoxyspatheliacromen (5-methoxyspatheliabischromen); limonoid deacetylspathelin and protolimonoid C-21-epimers 3β-angeloyloxy-7α,24,25-trihydroxy-21,23-oxide-14,18-cycloapotirucall-21-hemiacetal; the alkaloids 7,8-dimethoxyflindersin, casimiroin and N-methyl-4,7,8-trimethoxyquinolin-2(1H)-one, besides a mixture of β-sitosterol and stigmasterol. Assays on promastigote forms of Leishmania braziliensis, deacetylspathelin showed moderate activity; and on epimastigote forms of Trypanossoma cruzi, 10(2,3-epoxy-3-methylbutanyl)spatheliachromen exhibited strong activity (IC50 = 11 µg mL-1).Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000600014Journal of the Brazilian Chemical Society v.20 n.6 2009reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532009000600014info:eu-repo/semantics/openAccessMoreira,Wagner A. dos SantosLima,Maria da PazFerreira,Antonio GilbertoFerreira,Izabel C. PilotoNakamura,Celso V.eng2009-08-04T00:00:00Zoai:scielo:S0103-50532009000600014Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2009-08-04T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
title Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
spellingShingle Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
Moreira,Wagner A. dos Santos
Rutaceae
Spathelia
Trypanossoma cruzi
Leishmania braziliensis
title_short Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
title_full Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
title_fullStr Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
title_full_unstemmed Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
title_sort Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
author Moreira,Wagner A. dos Santos
author_facet Moreira,Wagner A. dos Santos
Lima,Maria da Paz
Ferreira,Antonio Gilberto
Ferreira,Izabel C. Piloto
Nakamura,Celso V.
author_role author
author2 Lima,Maria da Paz
Ferreira,Antonio Gilberto
Ferreira,Izabel C. Piloto
Nakamura,Celso V.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Moreira,Wagner A. dos Santos
Lima,Maria da Paz
Ferreira,Antonio Gilberto
Ferreira,Izabel C. Piloto
Nakamura,Celso V.
dc.subject.por.fl_str_mv Rutaceae
Spathelia
Trypanossoma cruzi
Leishmania braziliensis
topic Rutaceae
Spathelia
Trypanossoma cruzi
Leishmania braziliensis
description Phytochemical investigation from roots of Spathelia excelsa yielded the chromones 10(2,3-epoxy-3-methylbutanyl) spatheliachromen and 10(2,3-dihydroxy-3-methylbutanyl) methoxyspatheliacromen (5-methoxyspatheliabischromen); limonoid deacetylspathelin and protolimonoid C-21-epimers 3β-angeloyloxy-7α,24,25-trihydroxy-21,23-oxide-14,18-cycloapotirucall-21-hemiacetal; the alkaloids 7,8-dimethoxyflindersin, casimiroin and N-methyl-4,7,8-trimethoxyquinolin-2(1H)-one, besides a mixture of β-sitosterol and stigmasterol. Assays on promastigote forms of Leishmania braziliensis, deacetylspathelin showed moderate activity; and on epimastigote forms of Trypanossoma cruzi, 10(2,3-epoxy-3-methylbutanyl)spatheliachromen exhibited strong activity (IC50 = 11 µg mL-1).
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000600014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000600014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532009000600014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.20 n.6 2009
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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