Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentials
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100077 |
Resumo: | Dielectric characterization has been applied as a convenient tool for evaluation of transport and polarization mechanisms in soft materials. In this work, we have explored the study of charge transport mechanisms in alginate hydrogel containing neomycin-loaded liposomes. For comparison, drug release kinetic was evaluated by using UV-Vis spectrophotometry and electrical impedance spectroscopy (EIS) at different external direct current (DC) polarization (100 mV and 1 V). The charge transfer resistance (Rct) was proportional to DC electrical stimulation and inversely to the amount of released neomycin. Optical and electrical measurements confirmed the dependence of neomycin release under influence of electrical potentials. The kinetic profile of these systems was described by zero-order model. In addition, the Korsmeyer-Peppas model also suggested a diffusion mechanism based on super case II transport (non-Fickian). These results encouraged the use of EIS as a “dark" spectroscopy technique, since EIS is effective for studies of release kinetics controlled by DC external electrical excitation. |
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Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentialscontrolled releasehydrogelalginateliposomesimpedance spectroscopyDielectric characterization has been applied as a convenient tool for evaluation of transport and polarization mechanisms in soft materials. In this work, we have explored the study of charge transport mechanisms in alginate hydrogel containing neomycin-loaded liposomes. For comparison, drug release kinetic was evaluated by using UV-Vis spectrophotometry and electrical impedance spectroscopy (EIS) at different external direct current (DC) polarization (100 mV and 1 V). The charge transfer resistance (Rct) was proportional to DC electrical stimulation and inversely to the amount of released neomycin. Optical and electrical measurements confirmed the dependence of neomycin release under influence of electrical potentials. The kinetic profile of these systems was described by zero-order model. In addition, the Korsmeyer-Peppas model also suggested a diffusion mechanism based on super case II transport (non-Fickian). These results encouraged the use of EIS as a “dark" spectroscopy technique, since EIS is effective for studies of release kinetics controlled by DC external electrical excitation.Sociedade Brasileira de Química2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100077Journal of the Brazilian Chemical Society v.27 n.1 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150249info:eu-repo/semantics/openAccessSilva,Rafael R.Lima,Sandro V. deSilva,Gustavo H. R. C.Oliveira,Helinando P. deOliveira,Maria D. L.Andrade,Cesar A. S.eng2016-03-09T00:00:00Zoai:scielo:S0103-50532016000100077Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-03-09T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentials |
title |
Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentials |
spellingShingle |
Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentials Silva,Rafael R. controlled release hydrogel alginate liposomes impedance spectroscopy |
title_short |
Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentials |
title_full |
Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentials |
title_fullStr |
Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentials |
title_full_unstemmed |
Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentials |
title_sort |
Dielectric Behavior of Alginate-Based Hydrogel Containing Neomycin-Loaded Lipid Nanovesicles under Influence of Electrical Potentials |
author |
Silva,Rafael R. |
author_facet |
Silva,Rafael R. Lima,Sandro V. de Silva,Gustavo H. R. C. Oliveira,Helinando P. de Oliveira,Maria D. L. Andrade,Cesar A. S. |
author_role |
author |
author2 |
Lima,Sandro V. de Silva,Gustavo H. R. C. Oliveira,Helinando P. de Oliveira,Maria D. L. Andrade,Cesar A. S. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Rafael R. Lima,Sandro V. de Silva,Gustavo H. R. C. Oliveira,Helinando P. de Oliveira,Maria D. L. Andrade,Cesar A. S. |
dc.subject.por.fl_str_mv |
controlled release hydrogel alginate liposomes impedance spectroscopy |
topic |
controlled release hydrogel alginate liposomes impedance spectroscopy |
description |
Dielectric characterization has been applied as a convenient tool for evaluation of transport and polarization mechanisms in soft materials. In this work, we have explored the study of charge transport mechanisms in alginate hydrogel containing neomycin-loaded liposomes. For comparison, drug release kinetic was evaluated by using UV-Vis spectrophotometry and electrical impedance spectroscopy (EIS) at different external direct current (DC) polarization (100 mV and 1 V). The charge transfer resistance (Rct) was proportional to DC electrical stimulation and inversely to the amount of released neomycin. Optical and electrical measurements confirmed the dependence of neomycin release under influence of electrical potentials. The kinetic profile of these systems was described by zero-order model. In addition, the Korsmeyer-Peppas model also suggested a diffusion mechanism based on super case II transport (non-Fickian). These results encouraged the use of EIS as a “dark" spectroscopy technique, since EIS is effective for studies of release kinetics controlled by DC external electrical excitation. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100077 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100077 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20150249 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.27 n.1 2016 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318177900822528 |