Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acids

Detalhes bibliográficos
Autor(a) principal: Srivastava,R.M
Data de Publicação: 1997
Outros Autores: Seabra,G.M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531997000400013
Resumo: The synthesis of title compounds 3a-g, from arylamidoximes 1a-g and succinic anhydride in high yields is described. 1,2,4-Oxadiazoles 3a-f were also obtained by carrying out the reaction in a domestic microwave oven. Preliminary pharmacological evaluations demonstrated that 3b-e possess analgesic properties. Ab initio molecular orbital calculations of the type STO-3G have been performed for compounds 3a, 4a, 5a and 6a.
id SBQ-2_2f9458c1b102d3cb956e10c707cf82f7
oai_identifier_str oai:scielo:S0103-50531997000400013
network_acronym_str SBQ-2
network_name_str Journal of the Brazilian Chemical Society (Online)
repository_id_str
spelling Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acidsarylamidoximesbis-1,2,4-oxadiazolesdiaryl-1,2,4-oxadiazolesab-initio sto-3g calculationsThe synthesis of title compounds 3a-g, from arylamidoximes 1a-g and succinic anhydride in high yields is described. 1,2,4-Oxadiazoles 3a-f were also obtained by carrying out the reaction in a domestic microwave oven. Preliminary pharmacological evaluations demonstrated that 3b-e possess analgesic properties. Ab initio molecular orbital calculations of the type STO-3G have been performed for compounds 3a, 4a, 5a and 6a.Sociedade Brasileira de Química1997-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531997000400013Journal of the Brazilian Chemical Society v.8 n.4 1997reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50531997000400013info:eu-repo/semantics/openAccessSrivastava,R.MSeabra,G.Meng2010-11-19T00:00:00Zoai:scielo:S0103-50531997000400013Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-11-19T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acids
title Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acids
spellingShingle Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acids
Srivastava,R.M
arylamidoximes
bis-1,2,4-oxadiazoles
diaryl-1,2,4-oxadiazoles
ab-initio sto-3g calculations
title_short Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acids
title_full Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acids
title_fullStr Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acids
title_full_unstemmed Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acids
title_sort Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl&#093: propionic acids
author Srivastava,R.M
author_facet Srivastava,R.M
Seabra,G.M
author_role author
author2 Seabra,G.M
author2_role author
dc.contributor.author.fl_str_mv Srivastava,R.M
Seabra,G.M
dc.subject.por.fl_str_mv arylamidoximes
bis-1,2,4-oxadiazoles
diaryl-1,2,4-oxadiazoles
ab-initio sto-3g calculations
topic arylamidoximes
bis-1,2,4-oxadiazoles
diaryl-1,2,4-oxadiazoles
ab-initio sto-3g calculations
description The synthesis of title compounds 3a-g, from arylamidoximes 1a-g and succinic anhydride in high yields is described. 1,2,4-Oxadiazoles 3a-f were also obtained by carrying out the reaction in a domestic microwave oven. Preliminary pharmacological evaluations demonstrated that 3b-e possess analgesic properties. Ab initio molecular orbital calculations of the type STO-3G have been performed for compounds 3a, 4a, 5a and 6a.
publishDate 1997
dc.date.none.fl_str_mv 1997-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531997000400013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531997000400013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50531997000400013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.8 n.4 1997
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
_version_ 1750318163051937792

Registros relacionados