Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activity

Detalhes bibliográficos
Autor(a) principal: Silva,Fernando C
Data de Publicação: 2011
Outros Autores: Duarte,Lucienir P, Silva,Grácia D. F, V. Filho,Sidney A, Lula,Ivana S, Takahashi,Jacqueline A, Sallum,William S. T
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000500018
Resumo: Six pentacyclic triterpenes were isolated from branches of Maytenus gonoclada (Celastraceae) and all NMR data of a new compound 3-oxo-12α,29-dihydroxyfriedelane are herein reported. The stereochemistry of the new friedelane was established by bidimensional NMR (HSQC, HMBC and NOESY) data, and its molecular weight confirmed by ESI mass spectrometry. Antimicrobial activity assays using the method of disk diffusion and macrodilution were carried out against the bacteria Escherichia coli, Citrobacter freundii, and Bacillus cereus, and against the fungi Candida albicans. The triterpene 3-oxo-12α-hydroxyfriedelane showed positive result against C. albicans.
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spelling Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activityMaytenus gonocladaCelastraceae3-oxo-12α-hydroxyfriedelane3-oxo-12α,29-dihydroxyfriedelaneantimicrobial activitySix pentacyclic triterpenes were isolated from branches of Maytenus gonoclada (Celastraceae) and all NMR data of a new compound 3-oxo-12α,29-dihydroxyfriedelane are herein reported. The stereochemistry of the new friedelane was established by bidimensional NMR (HSQC, HMBC and NOESY) data, and its molecular weight confirmed by ESI mass spectrometry. Antimicrobial activity assays using the method of disk diffusion and macrodilution were carried out against the bacteria Escherichia coli, Citrobacter freundii, and Bacillus cereus, and against the fungi Candida albicans. The triterpene 3-oxo-12α-hydroxyfriedelane showed positive result against C. albicans.Sociedade Brasileira de Química2011-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000500018Journal of the Brazilian Chemical Society v.22 n.5 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011000500018info:eu-repo/semantics/openAccessSilva,Fernando CDuarte,Lucienir PSilva,Grácia D. FV. Filho,Sidney ALula,Ivana STakahashi,Jacqueline ASallum,William S. Teng2011-05-16T00:00:00Zoai:scielo:S0103-50532011000500018Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-05-16T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activity
title Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activity
spellingShingle Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activity
Silva,Fernando C
Maytenus gonoclada
Celastraceae
3-oxo-12α-hydroxyfriedelane
3-oxo-12α,29-dihydroxyfriedelane
antimicrobial activity
title_short Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activity
title_full Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activity
title_fullStr Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activity
title_full_unstemmed Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activity
title_sort Chemical constituents from branches of Maytenus gonoclada (Celastraceae) and evaluation of antimicrobial activity
author Silva,Fernando C
author_facet Silva,Fernando C
Duarte,Lucienir P
Silva,Grácia D. F
V. Filho,Sidney A
Lula,Ivana S
Takahashi,Jacqueline A
Sallum,William S. T
author_role author
author2 Duarte,Lucienir P
Silva,Grácia D. F
V. Filho,Sidney A
Lula,Ivana S
Takahashi,Jacqueline A
Sallum,William S. T
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva,Fernando C
Duarte,Lucienir P
Silva,Grácia D. F
V. Filho,Sidney A
Lula,Ivana S
Takahashi,Jacqueline A
Sallum,William S. T
dc.subject.por.fl_str_mv Maytenus gonoclada
Celastraceae
3-oxo-12α-hydroxyfriedelane
3-oxo-12α,29-dihydroxyfriedelane
antimicrobial activity
topic Maytenus gonoclada
Celastraceae
3-oxo-12α-hydroxyfriedelane
3-oxo-12α,29-dihydroxyfriedelane
antimicrobial activity
description Six pentacyclic triterpenes were isolated from branches of Maytenus gonoclada (Celastraceae) and all NMR data of a new compound 3-oxo-12α,29-dihydroxyfriedelane are herein reported. The stereochemistry of the new friedelane was established by bidimensional NMR (HSQC, HMBC and NOESY) data, and its molecular weight confirmed by ESI mass spectrometry. Antimicrobial activity assays using the method of disk diffusion and macrodilution were carried out against the bacteria Escherichia coli, Citrobacter freundii, and Bacillus cereus, and against the fungi Candida albicans. The triterpene 3-oxo-12α-hydroxyfriedelane showed positive result against C. albicans.
publishDate 2011
dc.date.none.fl_str_mv 2011-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000500018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000500018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532011000500018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.22 n.5 2011
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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